Preliminary experience with dexmedetomidine for monitored anesthesia care during ENT surgical procedures

American Journal of Therapeutics

Volumn 15, Issue 6, 2008, Pages 520-527

  Busick, Tamra ^a   Kussman, Mary ^a   Scheidt, Troy ^a   Tobias, Joseph D ^a  

^a University of Missouri   (United States)

Author keywords

Dexmedetomidine; ENT procedures; Monitored anesthesia care

Indexed keywords

ACETYLSALICYLIC ACID; AMANTADINE; BOTULINUM TOXIN; CLONAZEPAM; DEXMEDETOMIDINE; DILTIAZEM; IPRATROPIUM BROMIDE; LANSOPRAZOLE; METOCLOPRAMIDE; MIRTAZAPINE; MONTELUKAST; OXYCODONE; SALBUTAMOL; SERTRALINE; ZOLPIDEM;

ADULT; AGED; ANESTHESIA; ARTICLE; CASE REPORT; CRICOPHARYNGEUS MUSCLE; EAR NOSE THROAT SURGERY; ESOPHAGOSCOPY; FEMALE; HUMAN; LOADING DRUG DOSE; MALE; PATIENT MONITORING; POSTPOLIOMYELITIS SYNDROME; PRIORITY JOURNAL; SEDATION; THYROID SURGERY; WAKEFULNESS;

ADRENERGIC ALPHA-AGONISTS; AGED; ANESTHETICS, LOCAL; DEXMEDETOMIDINE; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; MALE; MIDDLE AGED; MONITORING, INTRAOPERATIVE; OTORHINOLARYNGOLOGIC SURGICAL PROCEDURES;

EID: 57649115457     PISSN: 10752765     EISSN: None     Source Type: Journal    
DOI: 10.1097/MJT.0b013e31815ae755     Document Type: Article

References (25)

1. Belleville JP, Ward DS, Bloor BC, et al. Effects of intravenous dexmedetomidine in humans. I. Sedation, ventilation and metabolic rate. Anesthesiology. 1992;77:1125-1133.
2. Maze M, Traquilli W. Alpha-2 adrenergic agonists: defining the role in clinical anesthesia. Anesthesiology. 1991;74:582-605.
3. Hall JE, Uhrich TD, Barney JA, et al. Sedative, amnestic, and analgesic properties of small-dose dexmedetomidine infusions. Anesth Analg. 2000;90:699-705.
4. Khan ZP, Munday IT, Jones RM. Effects of dexmedetomidine on isoflurane requirements in healthy volunteers. 1. Pharmacodynamic and pharmacokinetic interactions. Br J Anaesth. 1999;83:372-380.
5. Santhanam S, Templeton L. Superficial cervical plexus block for vocal cord surgery in an awake pediatric patient. Anesth Analg. 2004;98:1656-1657.
6. Ramsay MAE, Luterman DL. Dexmedetomidine as a total intravenous anesthetic agent. Anesthesiology. 2004;101:787-790.
7. 2 agonist in the rat. J Pharmacol Exp Ther. 1992;263:1046-1050.
8. 2 adrenergic agonist dexmedetomidine in the locus cereleus of the rat. Anesthesiology. 1994;81:1527-1534.
9. 2+ channels due to phosphorylation by cAMP-dependent protein kinase. Nature. 1993;364:240-243.
10. 2 agonist is mediated in the locus cereleus in rats. Anesthesiology. 1992;76:948-952.
11. Doze VA, Chen BX, Maze M. Dexmedetomidine produces a hypnotic-anesthetic action in rats via activation of central alpha-2 adrenoceptors. Anesthesiology. 1989;71:75-79.
12. 2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects. Anesthesiology. 2003;98:428-436.
13. Bloor BC, Ward DS, Belleville JP, et al. Effects of intravenous dexmedetomidine in humans. II. Hemodynamic changes. Anesthesiology. 1992;77:1134-1142.
14. Peden CJ, Cloote AH, Stratford N, et al. The effect of intravenous dexmedetomidine premedication on the dose requirement of propofol to induce loss of consciousness in patients receiving alfentanil. Anaesthesia. 2001;56:408-413.
15. Venn RM, Bradshaw CJ, Spencer R, et al. Preliminary UK experience of dexmedetomidine, a novel agent for postoperative sedation in the intensive care unit. Anaesthesia. 1999;54:1136-1142.
16. Ingersoll-Weng E, Manecke GR, Thistlethwaite PA. Dexmedetomidine and cardiac arrest. Anesthesiology. 2004;100:738-739.
17. Scheinin H, Jaakola ML, Sjovall S, et al. Intramuscular dexmedetomidine as premedication for general anesthesia. A comparative multicenter study. Anesthesiology. 1993;78:1065-1075.
18. Khan ZP, Munday IT, Jones RM. Effects of dexmedetomidine on isoflurane requirements in health volunteers. 1. Pharmacodynamic and pharmacokinetic interactions. Br J Anaesth. 1999;83:372-380.
19. Hsu YW, Cortinez LI, Robertson KM, et al. Dexmedetomidine pharmacodynamics: crossover comparison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers. Anesthesiology. 2004;101:1059-1061.
20. 2- agonist, does not potentiate the cardiorespiratory depression of alfentanil in the rat. Anesthesiology. 1990;72:882-888.
21. Ho AMH, Chen S, Karmakar MK. Central apnoea after balanced general anaesthesia that included dexmedetomidine. Br J Anaesth. 2005;95:773-775.
22. Arain SR, Ebert TJ. The efficacy, side effects, and recovery characteristics of dexmedetomidine versus propofol when used for intraoperative sedation. Anesth Analgesia. 2002;95:461-166.
23. Koroglu A, Teksan H, Sagir O, et al. A comparison of the sedative, hemodynamic and respiratory effects of dexmedetomidine and propofol in children undergoing magnetic resonance imaging. Anesth Analg. 2006;103:63-67.
24. Jalowiecki P, Rudner R, Gonciarz M, et al. Sole use of dexmedetomidine has limited utility for conscious sedation during outpatient colonoscopy. Anesthesiology. 2005;103:269-273.
25. Alhashemi JA. Dexmedetomidine vs. midazolam for monitored anaesthesia care during cataract surgery. Br J Anaesth. 2006;96:722-726.