메뉴 건너뛰기




Volumn 10, Issue 6, 2008, Pages

T-614, a novel immunomodulator, attenuates joint inflammation and articular damage in collagen-induced arthritis

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; COLLAGEN ANTIBODY; COLLAGEN TYPE 2 ANTIBODY; GAMMA INTERFERON; IGURATIMOD; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN M; IMMUNOMODULATING AGENT; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; METHOTREXATE; NIMESULIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AUTACOID; BENZOPYRAN DERIVATIVE; SULFONAMIDE;

EID: 57649112539     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar2554     Document Type: Article
Times cited : (73)

References (49)
  • 1
    • 0242609352 scopus 로고    scopus 로고
    • Inhibitory effects of an anti-rheumatic agent T-614 on immunoglobulin production by cultured B cells and rheumatoid synovial tissues engrafted into SCID mice
    • 10.1093/rheumatology/keg381 12810927
    • Tanaka K Yamamoto T Aikawa Y Kizawa K Muramoto K Matsuno H Muraguchi A Inhibitory effects of an anti-rheumatic agent T-614 on immunoglobulin production by cultured B cells and rheumatoid synovial tissues engrafted into SCID mice Rheumatology (Oxford) 2003, 42:1365-1371 10.1093/ rheumatology/keg381 12810927
    • (2003) Rheumatology (Oxford) , vol.42 , pp. 1365-1371
    • Tanaka, K.1    Yamamoto, T.2    Aikawa, Y.3    Kizawa, K.4    Muramoto, K.5    Matsuno, H.6    Muraguchi, A.7
  • 2
    • 0033825257 scopus 로고    scopus 로고
    • Inhibition of L-leucine methyl ester mediated killing of THP-1, a human monocytic cell line, by a new anti-inflammatory drug, T614
    • 10.1016/S0162-3109(00)00242-3 10996026
    • Sawada T Hashimoto S Tohma S Nishioka Y Nagai T Sato T Ito K Inoue T Iwata M Yamamoto K Inhibition of L-leucine methyl ester mediated killing of THP-1, a human monocytic cell line, by a new anti-inflammatory drug, T614 Immunopharmacology 2000, 49:285-294 10.1016/S0162-3109(00)00242-3 10996026
    • (2000) Immunopharmacology , vol.49 , pp. 285-294
    • Sawada, T.1    Hashimoto, S.2    Tohma, S.3    Nishioka, Y.4    Nagai, T.5    Sato, T.6    Ito, K.7    Inoue, T.8    Iwata, M.9    Yamamoto, K.10
  • 3
    • 0029016804 scopus 로고
    • T-614, a novel antirheumatic drug, inhibits both the activity and induction of cyclooxygenase-2 (COX-2) in cultured fibroblasts
    • 10.1254/jjp.67.305 7650864
    • Tanaka K Kawasaki H Kurata K Aikawa Y Tsukamoto Y Inaba T T-614, a novel antirheumatic drug, inhibits both the activity and induction of cyclooxygenase-2 (COX-2) in cultured fibroblasts Jpn J Pharmacol 1995, 67:305-314 10.1254/jjp.67.305 7650864
    • (1995) Jpn J Pharmacol , vol.67 , pp. 305-314
    • Tanaka, K.1    Kawasaki, H.2    Kurata, K.3    Aikawa, Y.4    Tsukamoto, Y.5    Inaba, T.6
  • 4
    • 46449101583 scopus 로고    scopus 로고
    • Safety and efficacy of T-614 in the treatment of patients with active rheumatoid arthritis: A double blind, randomized, placebo-controlled and multicenter trial
    • 18466681
    • Lu LJ Teng JL Bao CD Han XH Sun LY Xu JH Li XF Wu HX Safety and efficacy of T-614 in the treatment of patients with active rheumatoid arthritis: a double blind, randomized, placebo-controlled and multicenter trial Chin Med J (Engl) 2008, 121:615-619 18466681
    • (2008) Chin Med J (Engl) , vol.121 , pp. 615-619
    • Lu, L.J.1    Teng, J.L.2    Bao, C.D.3    Han, X.H.4    Sun, L.Y.5    Xu, J.H.6    Li, X.F.7    Wu, H.X.8
  • 5
    • 34948879612 scopus 로고    scopus 로고
    • The immunology of rheumatoid arthritis
    • 10.1196/annals.1422.033 17893995
    • Scrivo R Di Franco M Spadaro A Valesini G The immunology of rheumatoid arthritis Ann N Y Acad Sci 2007, 1108:312-322 10.1196/annals.1422.033 17893995
    • (2007) Ann N Y Acad Sci , vol.1108 , pp. 312-322
    • Scrivo, R.1    Di Franco, M.2    Spadaro, A.3    Valesini, G.4
  • 6
    • 40549138508 scopus 로고    scopus 로고
    • Cells of the synovium in rheumatoid arthritis. Dendritic cells
    • 2206384 17850683 10.1186/ar2200
    • Lutzky V Hannawi S Thomas R Cells of the synovium in rheumatoid arthritis. Dendritic cells Arthritis Res Ther 2007, 9:219-231 2206384 17850683 10.1186/ar2200
    • (2007) Arthritis Res Ther , vol.9 , pp. 219-231
    • Lutzky, V.1    Hannawi, S.2    Thomas, R.3
  • 8
  • 9
    • 0033083111 scopus 로고    scopus 로고
    • IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells
    • 9973376
    • Aarvak T Chabaud M Miossec P Natvig JB IL-17 is produced by some proinflammatory Th1/Th0 cells but not by Th2 cells J Immunol 1999, 162:1246-1251 9973376
    • (1999) J Immunol , vol.162 , pp. 1246-1251
    • Aarvak, T.1    Chabaud, M.2    Miossec, P.3    Natvig, J.B.4
  • 10
    • 13444256307 scopus 로고    scopus 로고
    • The role of T-cell interleukin-17 in conducting destructive arthritis: Lessons from animal models
    • 1064899 15642151 10.1186/ar1478
    • Lubberts E Koenders MI Berg van den WB The role of T-cell interleukin-17 in conducting destructive arthritis: Lessons from animal models Arthritis Res Ther 2005, 7:29-37 1064899 15642151 10.1186/ar1478
    • (2005) Arthritis Res Ther , vol.7 , pp. 29-37
    • Lubberts, E.1    Koenders, M.I.2    Berg, W.B.3
  • 11
    • 5644289875 scopus 로고    scopus 로고
    • IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-kappaB- and PI3-kinase/Akt-dependent pathways
    • 400429 15059275 10.1186/ar1038
    • Hwang SY Kim JY Kim KW Park MK Moon Y Kim WU Kim HY IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-kappaB- and PI3-kinase/Akt-dependent pathways Arthritis Res Ther 2004, 6:R120-128 400429 15059275 10.1186/ar1038
    • (2004) Arthritis Res Ther , vol.6
    • Hwang, S.Y.1    Kim, J.Y.2    Kim, K.W.3    Park, M.K.4    Moon, Y.5    Kim, W.U.6    Kim, H.Y.7
  • 12
    • 18644375615 scopus 로고    scopus 로고
    • Increased AP-1 and NF-kappaB activation and recruitment with the combination of the proinflammatory cytokines IL-1beta, tumor necrosis factor alpha and IL-17 in rheumatoid synoviocytes
    • 416439 15142264 10.1186/ar1159
    • Granet C Maslinski W Miossec P Increased AP-1 and NF-kappaB activation and recruitment with the combination of the proinflammatory cytokines IL-1beta, tumor necrosis factor alpha and IL-17 in rheumatoid synoviocytes Arthritis Res Ther 2004, 6:R190-198 416439 15142264 10.1186/ ar1159
    • (2004) Arthritis Res Ther , vol.6
    • Granet, C.1    Maslinski, W.2    Miossec, P.3
  • 13
    • 0242304091 scopus 로고    scopus 로고
    • Gene expression induced by interleukin-17 in fibroblast-like synoviocytes of patients with rheumatoid arthritis: Upregulation of hyaluronan-binding protein TSG-6
    • 165059 12823853 10.1186/ar762
    • Kehlen A Pachnio A Thiele K Langner J Gene expression induced by interleukin-17 in fibroblast-like synoviocytes of patients with rheumatoid arthritis: Upregulation of hyaluronan-binding protein TSG-6 Arthritis Res Ther 2003, 5:R186-192 165059 12823853 10.1186/ar762
    • (2003) Arthritis Res Ther , vol.5
    • Kehlen, A.1    Pachnio, A.2    Thiele, K.3    Langner, J.4
  • 14
    • 0036785194 scopus 로고    scopus 로고
    • Interleukin 17 synergises with tumour necrosis factor alpha to induce cartilage destruction in vitro
    • 1753923 12228154 10.1136/ard.61.10.870
    • Van Bezooijen RL Wee-Pals Van Der L Papapoulos SE Lowik CW Interleukin 17 synergises with tumour necrosis factor alpha to induce cartilage destruction in vitro Ann Rheum Dis 2002, 61:870-876 1753923 12228154 10.1136/ard.61.10.870
    • (2002) Ann Rheum Dis , vol.61 , pp. 870-876
    • Van Bezooijen, R.L.1    Wee-Pals, L.2    Papapoulos, S.E.3    Lowik, C.W.4
  • 15
    • 0033926254 scopus 로고    scopus 로고
    • Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis
    • 10.1006/cyto.2000.0681 10880256
    • Chabaud M Garnero P Dayer JM Guerne PA Fossiez F Miossec P Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis Cytokine 2000, 12:1092-1099 10.1006/cyto.2000.0681 10880256
    • (2000) Cytokine , vol.12 , pp. 1092-1099
    • Chabaud, M.1    Garnero, P.2    Dayer, J.M.3    Guerne, P.A.4    Fossiez, F.5    Miossec, P.6
  • 17
  • 20
    • 1042267236 scopus 로고    scopus 로고
    • Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion
    • 10.1002/art.20001 14872510
    • Lubberts E Koenders MI Oppers-Walgreen B Bersselaar van den L Coenen-de Roo CJ Joosten LA Berg van den WB Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion Arthritis Rheum 2004, 50:650-659 10.1002/art.20001 14872510
    • (2004) Arthritis Rheum , vol.50 , pp. 650-659
    • Lubberts, E.1    Koenders, M.I.2    Oppers-Walgreen, B.3    Bersselaar, L.4    Coenen-de Roo, C.J.5    Joosten, L.A.6    Berg, W.B.7
  • 21
    • 0344585384 scopus 로고    scopus 로고
    • Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice
    • 14634133
    • Nakae S Nambu A Sudo K Iwakura Y Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice J Immunol 2003, 171:6173-7 14634133
    • (2003) J Immunol , vol.171 , pp. 6173-6177
    • Nakae, S.1    Nambu, A.2    Sudo, K.3    Iwakura, Y.4
  • 25
    • 0031728092 scopus 로고    scopus 로고
    • Collagen induced arthritis: Reversal by mercaptoethylguanidine, a novel antiinflammatory agent with a combined mechanism of action
    • 9733461
    • Brahn E Banquerigo ML Firestein GS Boyle DL Salzman AL Szabo C Collagen induced arthritis: Reversal by mercaptoethylguanidine, a novel antiinflammatory agent with a combined mechanism of action J Rheumatol 1998, 25:1785-1793 9733461
    • (1998) J Rheumatol , vol.25 , pp. 1785-1793
    • Brahn, E.1    Banquerigo, M.L.2    Firestein, G.S.3    Boyle, D.L.4    Salzman, A.L.5    Szabo, C.6
  • 27
    • 16244399808 scopus 로고    scopus 로고
    • Rheumatoid arthritis
    • 10.1111/j.0105-2896.2005.00245.x 15790350
    • Goronzy JJ Weyand CM Rheumatoid arthritis Immunol Rev 2005, 204:55-73 10.1111/j.0105-2896.2005.00245.x 15790350
    • (2005) Immunol Rev , vol.204 , pp. 55-73
    • Goronzy, J.J.1    Weyand, C.M.2
  • 28
    • 1942500129 scopus 로고    scopus 로고
    • Signal transduction in rheumatoid arthritis
    • 10.1097/00002281-200405000-00011 15103250
    • Sweeney SE Firestein GS Signal transduction in rheumatoid arthritis Curr Opin Rheumatol 2004, 16:231-237 10.1097/00002281-200405000-00011 15103250
    • (2004) Curr Opin Rheumatol , vol.16 , pp. 231-237
    • Sweeney, S.E.1    Firestein, G.S.2
  • 30
    • 33750474405 scopus 로고    scopus 로고
    • Interleukin 6: From bench to bedside
    • 10.1038/ncprheum0338 17075601
    • Nishimoto N Kishimoto T Interleukin 6: From bench to bedside Nat Clin Pract Rheumatol 2006, 2:619-626 10.1038/ncprheum0338 17075601
    • (2006) Nat Clin Pract Rheumatol , vol.2 , pp. 619-626
    • Nishimoto, N.1    Kishimoto, T.2
  • 32
    • 20744440158 scopus 로고    scopus 로고
    • Effectiveness of recommendations to prevent reactivation of latent tuberculosis infection in patients treated with tumor necrosis factor antagonists
    • 10.1002/art.21043 15934089
    • Carmona L Gomez-Reino JJ Rodriguez-Valverde V Montero D Pascual-Gomez E Mola EM Carreno L Figueroa M Effectiveness of recommendations to prevent reactivation of latent tuberculosis infection in patients treated with tumor necrosis factor antagonists Arthritis Rheum 2005, 52:1766-1772 10.1002/art.21043 15934089
    • (2005) Arthritis Rheum , vol.52 , pp. 1766-1772
    • Carmona, L.1    Gomez-Reino, J.J.2    Rodriguez-Valverde, V.3    Montero, D.4    Pascual-Gomez, E.5    Mola, E.M.6    Carreno, L.7    Figueroa, M.8
  • 33
    • 33748310559 scopus 로고    scopus 로고
    • Antirheumatic drugs and the risk of tuberculosis
    • 10.1086/506935 16912945
    • Brassard P Kezouh A Suissa S Antirheumatic drugs and the risk of tuberculosis Clin Infect Dis 2006, 43:717-722 10.1086/506935 16912945
    • (2006) Clin Infect Dis , vol.43 , pp. 717-722
    • Brassard, P.1    Kezouh, A.2    Suissa, S.3
  • 34
    • 33747008410 scopus 로고    scopus 로고
    • Rates of serious infection, including site-specific and bacterial intracellular infection, in rheumatoid arthritis patients receiving anti-tumor necrosis factor therapy: Results from the British Society for Rheumatology Biologics Register
    • 10.1002/art.21978 16868999
    • Dixon WG Watson K Lunt M Hyrich KL Silman AJ Symmons DP Rates of serious infection, including site-specific and bacterial intracellular infection, in rheumatoid arthritis patients receiving anti-tumor necrosis factor therapy: Results from the British Society for Rheumatology Biologics Register Arthritis Rheum 2006, 54:2368-2376 10.1002/art.21978 16868999
    • (2006) Arthritis Rheum , vol.54 , pp. 2368-2376
    • Dixon, W.G.1    Watson, K.2    Lunt, M.3    Hyrich, K.L.4    Silman, A.J.5    Symmons, D.P.6
  • 36
    • 45349095153 scopus 로고    scopus 로고
    • The 2008 American College of Rheumatology recommendations for the use of nonbiologic and biologic disease-modifying antirheumatic drugs in rheumatoid arthritis: Where the rubber meets the road
    • 10.1002/art.23723 18512712
    • Bathon JM Cohen SB The 2008 American College of Rheumatology recommendations for the use of nonbiologic and biologic disease-modifying antirheumatic drugs in rheumatoid arthritis: Where the rubber meets the road Arthritis Rheum 2008, 59:757-759 10.1002/art.23723 18512712
    • (2008) Arthritis Rheum , vol.59 , pp. 757-759
    • Bathon, J.M.1    Cohen, S.B.2
  • 37
    • 16344390586 scopus 로고    scopus 로고
    • Methotrexate ameliorates T cell dependent autoimmune arthritis and encephalomyelitis but not antibody induced or fibroblast induced arthritis
    • 1755430 15345503 10.1136/ard.2004.026120
    • Lange F Bajtner E Rintisch C Nandakumar KS Sack U Holmdahl R Methotrexate ameliorates T cell dependent autoimmune arthritis and encephalomyelitis but not antibody induced or fibroblast induced arthritis Ann Rheum Dis 2005, 64:599-605 1755430 15345503 10.1136/ ard.2004.026120
    • (2005) Ann Rheum Dis , vol.64 , pp. 599-605
    • Lange, F.1    Bajtner, E.2    Rintisch, C.3    Nandakumar, K.S.4    Sack, U.5    Holmdahl, R.6
  • 38
    • 0033509827 scopus 로고    scopus 로고
    • A new spin on an old model: In vivo evaluation of disease progression by magnetic resonance imaging with respect to standard inflammatory parameters and histopathology in the adjuvant arthritic rat
    • 10.1002/1529-0131(199910)42:10<2060::AID-ANR6>3.0.CO;2-L 10524677
    • Jacobson PB Morgan SJ Wilcox DM Nguyen P Ratajczak CA Carlson RP Harris RR Nuss M A new spin on an old model: In vivo evaluation of disease progression by magnetic resonance imaging with respect to standard inflammatory parameters and histopathology in the adjuvant arthritic rat Arthritis Rheum 1999, 42:2060-2073 10.1002/ 1529-0131(199910)42:10<2060::AID-ANR6>3.0.CO;2-L 10524677
    • (1999) Arthritis Rheum , vol.42 , pp. 2060-2073
    • Jacobson, P.B.1    Morgan, S.J.2    Wilcox, D.M.3    Nguyen, P.4    Ratajczak, C.A.5    Carlson, R.P.6    Harris, R.R.7    Nuss, M.8
  • 40
    • 0035889931 scopus 로고    scopus 로고
    • Enhancing effect of IL-1, IL-17, and TNF-alpha on macrophage inflammatory protein-3alpha production in rheumatoid arthritis: Regulation by soluble receptors and Th2 cytokines
    • 11698482
    • Chabaud M Page G Miossec P Enhancing effect of IL-1, IL-17, and TNF-alpha on macrophage inflammatory protein-3alpha production in rheumatoid arthritis: Regulation by soluble receptors and Th2 cytokines J Immunol 2001, 167:6015-6020 11698482
    • (2001) J Immunol , vol.167 , pp. 6015-6020
    • Chabaud, M.1    Page, G.2    Miossec, P.3
  • 41
    • 38949197817 scopus 로고    scopus 로고
    • IL-17/Th17 targeting: On the road to prevent chronic destructive arthritis?
    • 10.1016/j.cyto.2007.09.014 18039580
    • Lubberts E IL-17/Th17 targeting: On the road to prevent chronic destructive arthritis? Cytokine 2008, 41:84-91 10.1016/ j.cyto.2007.09.014 18039580
    • (2008) Cytokine , vol.41 , pp. 84-91
    • Lubberts, E.1
  • 42
    • 0036234632 scopus 로고    scopus 로고
    • An anti-rheumatic agent T-614 inhibits NF-kappaB activation in LPS- and TNF-alpha-stimulated THP-1 cells without interfering with IkappaBalpha degradation
    • 10.1007/PL00000291 12058956
    • Aikawa Y Yamamoto M Yamamoto T Morimoto K Tanaka K An anti-rheumatic agent T-614 inhibits NF-kappaB activation in LPS- and TNF-alpha-stimulated THP-1 cells without interfering with IkappaBalpha degradation Inflamm Res 2002, 51:188-194 10.1007/PL00000291 12058956
    • (2002) Inflamm Res , vol.51 , pp. 188-194
    • Aikawa, Y.1    Yamamoto, M.2    Yamamoto, T.3    Morimoto, K.4    Tanaka, K.5
  • 43
    • 34547188748 scopus 로고    scopus 로고
    • IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    • 10.1038/ni1488 17581537
    • Zhou L Ivanov II Spolski R Min R Shenderov K Egawa T Levy DE Leonard WJ Littman DR IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways Nat Immunol 2007, 8:967-974 10.1038/ni1488 17581537
    • (2007) Nat Immunol , vol.8 , pp. 967-974
    • Zhou, L.1    Ivanov, I.I.2    Spolski, R.3    Min, R.4    Shenderov, K.5    Egawa, T.6    Levy, D.E.7    Leonard, W.J.8    Littman, D.R.9
  • 44
    • 0021246904 scopus 로고
    • Isolation and characterization of B cell differentiation factor (BCDF) secreted from a human B lymphoblastoid cell line
    • 6202767
    • Yoshizaki K Nakagawa T Fukunaga K Tseng LT Yamamura Y Kishimoto T Isolation and characterization of B cell differentiation factor (BCDF) secreted from a human B lymphoblastoid cell line J Immunol 1984, 132:2948-2954 6202767
    • (1984) J Immunol , vol.132 , pp. 2948-2954
    • Yoshizaki, K.1    Nakagawa, T.2    Fukunaga, K.3    Tseng, L.T.4    Yamamura, Y.5    Kishimoto, T.6
  • 45
    • 0038798085 scopus 로고    scopus 로고
    • Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis
    • 10.1002/art.11143 12794819
    • Nakahara H Song J Sugimoto M Hagihara K Kishimoto T Yoshizaki K Nishimoto N Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis Arthritis Rheum 2003, 48:1521-1529 10.1002/art.11143 12794819
    • (2003) Arthritis Rheum , vol.48 , pp. 1521-1529
    • Nakahara, H.1    Song, J.2    Sugimoto, M.3    Hagihara, K.4    Kishimoto, T.5    Yoshizaki, K.6    Nishimoto, N.7
  • 48
    • 34547863508 scopus 로고    scopus 로고
    • IgM plays an important role in induction of collagen-induced arthritis
    • 2219323 17590174
    • Zheng B Zhang X Guo L Han S IgM plays an important role in induction of collagen-induced arthritis Clin Exp Immunol 2007, 149:579-585 2219323 17590174
    • (2007) Clin Exp Immunol , vol.149 , pp. 579-585
    • Zheng, B.1    Zhang, X.2    Guo, L.3    Han, S.4
  • 49
    • 35348848012 scopus 로고    scopus 로고
    • Blocking of experimental arthritis by cleavage of IgG antibodies in vivo
    • 10.1002/art.22930 17907170
    • Nandakumar KS Johansson BP Bjorck L Holmdahl R Blocking of experimental arthritis by cleavage of IgG antibodies in vivo Arthritis Rheum 2007, 56:3253-3260 10.1002/art.22930 17907170
    • (2007) Arthritis Rheum , vol.56 , pp. 3253-3260
    • Nandakumar, K.S.1    Johansson, B.P.2    Bjorck, L.3    Holmdahl, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.