Determination of creatine and guanidinoacetate by GC-MS. Study of their stability in urine at different temperatures

Clinical Biochemistry

Volumn 42, Issue 1-2, 2009, Pages 125-128

  Prieto, José Angel ^a   Andrade, Fernando ^a   Martín, Sergio ^a   Sanjurjo, Pablo ^a   Elorz, Javier ^b   Aldámiz Echevarría, Luís ^a  

^a HOSPITAL DE CRUCES   (Spain)

^b HOSPITAL DE BASURTO   (Spain)

Author keywords

Creatine; Gas chromatography mass spectrometry; Guanidinoacetate; Stability; Urine

Indexed keywords

CREATINE; GUANIDINOACETIC ACID; N TERT BUTYLDIMETHYLSILYL N METHYLTRIFLUOROACETAMIDE; REAGENT; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ANALYTIC METHOD; ARTICLE; CALIBRATION; CHILD; DERIVATIZATION; FEMALE; FREEZING; GAS CHROMATOGRAPHY; HUMAN; MALE; MASS SPECTROMETRY; MEASUREMENT; MEDICAL INSTRUMENTATION; NORMAL HUMAN; PRIORITY JOURNAL; REFERENCE VALUE; SILYLATION; TEMPERATURE; URINE LEVEL;

CREATINE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLYCINE; HUMANS; ORGANOSILICON COMPOUNDS; TEMPERATURE; TRIFLUOROACETIC ACID;

EID: 57649110512     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2008.10.001     Document Type: Article

References (10)

1. Almeida L.S., Verhoeven N.M., Roos B., Valongo C., Cardoso M.L., Vilarinho L., et al. Creatine and guanidinoacetate: diagnostic markers for inborn errors in creatine biosynthesis and transport. Mol. Genet. Metab. 82 (2004) 214-219
2. Struys E.A., Jansen E.E., ten Brink H.J., Verhoeven N.M., van der Knaap M.S., and Jakobs C.J. An accurate stable isotope dilution gas chromatographic-mass spectrometric approach to the diagnosis of guanidinoacetate methyltransferase deficiency. J. Pharm. Biomed. Anal. 18 (1998) 659-665
3. Fingerhut R. Stable isotope dilution method for the determination of guanidinoacetic acid by gas chromatography/mass spectrometry. Rapid Commun. Mass Spectrom. 17 (2003) 717-722
4. Valongo C., Cardoso M.L., Domingues P., Almeida L., Verhoeven N., Salomons G., et al. Age related reference values for urine creatine and guanidinoacetic acid concentration in children and adolescents by gas chromatography-mass spectrometry. Clin. Chim. Acta 348 (2004) 155-161
5. MacNeil L., Hill L., MacDonald D., Keefe L., Cormier J.F., Burke D.G., et al. Analysis of creatine, creatinine, creatine-d3 and creatinine-d3 in urine, plasma, and red blood cells by HPLC and GC-MS to follow the fate of ingested creatine-d3. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 827 (2005) 210-215
6. Arias A., Ormazabal A., Moreno J., González B., Vilaseca M.A., García-Villoria J., et al. Methods for the diagnosis of creatine deficiency syndromes: a comparative study. Neurosci. Methods 156 (2006) 305-309
7. Cognat S., Cheillan D., Piraud M., Roos B., Jakobs C., and Vianey-Saban C. Determination of guanidinoacetate and creatine in urine and plasma by liquid chromatography-tandem mass spectrometry. Clin. Chem. 50 (2004) 1459-1461
8. Carducci C., Santagata S., Leuzzi V., Carducci C., Artiola C., Giovanniello T., et al. Quantitative determination of guanidinoacetate and creatine in dried blood spot by flow injection analysis-electrospray tandem mass spectrometry. Clin. Chim. Acta 364 (2006) 180-187
9. Saude E.J., and Sykes B.D. Urine stability for metabolomic studies: effects of preparation and storage. Metabolomics 3 (2007) 19-27
10. Bland J.M., and Altman D.G. Measurement error. Brit. J. Nutr. 312 (1996) 1654