The amount of 8.4% sodium bicarbonate needed to neutralize the acidity of rocuronium so as to prevent injection pain

Journal of Clinical Anesthesia

Volumn 20, Issue 8, 2008, Pages 629-630

  Kim, Seok K ^a   Kwon, Min A ^a   Park, Jeong S ^b  

^a Dankook University   (South Korea)

^b BK21 Plus NBM Global Research Center for Regenerative Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BICARBONATE; CARBON DIOXIDE; CARBONIC ACID; ROCURONIUM;

ACIDITY; COLOR; INJECTION PAIN; LETTER; PH; PRIORITY JOURNAL; TURBIDITY;

ANDROSTANOLS; CHEMISTRY, PHARMACEUTICAL; DRUG COMPOUNDING; DRUG STABILITY; HUMANS; HYDROGEN-ION CONCENTRATION; INJECTIONS; PAIN; SODIUM BICARBONATE; TIME FACTORS;

EID: 57649083922     PISSN: 09528180     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jclinane.2008.08.002     Document Type: Letter

References (2)

1. Han D.W., Koo B.N., Choi S.H., et al. Neutralized rocuronium (pH 7.4) before administration prevents injection pain in awake patients: a randomized prospective trial. J Clin Anesth 19 (2007) 418-423
2. Ono K., Nagano O., Ohta Y., and Kosaka F. Neuromuscular effects of respiratory and metabolic acid-base changes in vitro with and without nondepolarizing muscle relaxants. Anesthesiology 73 (1990) 710-716