Targeting the angiotensin pathway in idiopathic pulmonary fibrosis

Expert Opinion on Therapeutic Targets

Volumn 12, Issue 12, 2008, Pages 1587-1590

  Antoniu, Sabina Antonela ^a  

^a GRIGORE T POPA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

Angiotensin II type 1 receptors (AT1); Belomycin induced pulmonary fibrosis; Olmesartan; PD123319

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; ANGIOTENSIN 2 RECEPTOR; BLEOMYCIN; OLMESARTAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; DRUG TARGETING; FIBROGENESIS; HISTOPATHOLOGY; IDIOPATHIC DISEASE; LUNG FIBROSIS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION;

EID: 57549118874     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728220802515459     Document Type: Article

References (14)

1. Waseda Y, Yasui M, Nishizawa Y, et al. Angiotensin II type 2 receptor antagonist reduces bleomycin-induced pulmonary fibrosis in mice. Respir Res 2008;9:43
2. Selman M, Pardo A. Role of epithelial cells in idiopathic pulmonary fibrosis: from innocent targets to serial killers. Proc Am Thorac Soc 2006;3(4):364-72
3. Lee AA, Dillmann WH, Mcculloch AD, et al. Angiotensin II stimulates the autocrine production of transforming growth factor-β1 in adult rat cardiac fibroblasts. J Mol Cell Cardiol 1995;27(10):2347-57
4. De Mello WC, Specht P. Chronic blockade of angiotensin II AT1-receptors increased cell-to-cell communication, reduced fibrosis and improved impulse propagation in the failing heart. J Renin Angiotensin Aldosterone Syst 2006;7(4):201-5
5. Kagami S, Border WA, Miller DE, et al. Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-β expression in rat glomerular mesangial cells. J Clin Invest 1994;93(6):2431-7
6. Li X, Rayford H, Uhal BD. Essential roles for angiotensin receptor AT1a in bleomycin-induced apoptosis and lung fibrosis in mice. Am J Pathol 2003;163(6):2523-30
7. Papp M, Li X, Zhuang J, et al. Angiotensin receptor subtype AT(1) mediates alveolar epithelial cell apoptosis in response to ANG II. Am J Physiol Lung Cell Mol Physiol 2002;282(4):L713-8
8. Otsuka M, Takahashi H, Shiratori M, et al. Reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin II type 1 receptor antagonist. Thorax 2004;59(1):31-8
9. Yao HW, Zhu JP, Zhao MH, et al. Losartan attenuates bleomycin-induced pulmonary fibrosis in rats. Respiration 2006;73(2):236-42
10. Molina-Molina M, Serrano-Mollar A, Bulbena O, et al. Losartan attenuates bleomycin induced lung fibrosis by increasing prostaglandin E2 synthesis. Thorax 2006;61(7):604-10
11. Keogh KA, Standing J, Kane GC, et al. Angiotensin II antagonism fails to ameliorate bleomycin-induced pulmonary fibrosis in mice. Eur Respir J 2005;25(4):708-14
12. Uhal BD, Wang R, Laukka J, et al. Inhibition of amiodarone-induced lung fibrosis but not alveolitis by angiotensin system antagonists. Pharmacol Toxicol 2003;92(2):81-7
13. Uhal BD, Kim JK, Li X, et al. Angiotensin-TGF-β1 crosstalk in human idiopathic pulmonary fibrosis: autocrine mechanisms in myofibroblasts and macrophages. Curr Pharm Des 2007;13(12):1247-56
14. Li X, Molina-Molina M, Abdul-Hafez A, et al. Angiotensin converting enzyme-2 is protective but downregulated in human and experimental lung fibrosis. Am J Physiol Lung Cell Mol Physiol 2008;295(1):L178-85