The kinetics of feline leukaemia virus shedding in experimentally infected cats are associated with infection outcome

Veterinary Microbiology

Volumn 133, Issue 3, 2009, Pages 292-296

  Cattori, Valentino ^a   Tandon, Ravi ^a   Riond, Barbara ^a   Pepin, Andrea C ^a   Lutz, Hans ^a   Hofmann Lehmann, Regina ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Feline leukaemia virus; Pathogenesis; Real time TaqMan reverse transcriptase polymerase chain reaction; Retrovirus; Viral loads; Virus kinetics; Virus shedding; Virus host interaction

Indexed keywords

PROTEIN P27; RNA; VIRUS RNA;

ARTICLE; CAT; CAT DISEASE; CELL CULTURE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FECES; FELINE LEUKEMIA VIRUS; KINETICS; NONHUMAN; OUTCOME ASSESSMENT; PLASMA; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RISK ASSESSMENT; SALIVA; URINE; VIREMIA; VIRUS ISOLATION; VIRUS LOAD; VIRUS TRANSMISSION;

ANIMALS; CATS; FECES; KINETICS; LEUKEMIA VIRUS, FELINE; LEUKEMIA, FELINE; SALIVA; SPECIFIC PATHOGEN-FREE ORGANISMS; TIME FACTORS; VIRAL LOAD; VIRAL REGULATORY AND ACCESSORY PROTEINS; VIRUS SHEDDING;

FELIDAE;

EID: 57549116213     PISSN: 03781135     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetmic.2008.07.001     Document Type: Article

References (17)

1. Cattori V., Tandon R., Pepin A., Lutz H., and Hofmann-Lehmann R. Rapid detection of feline leukemia virus provirus integration into feline genomic DNA. Mol. Cell. Probes 20 (2006) 172-181
2. Francis D.P., and Essex M. Excretion of feline leukaemia virus by naturally infected pet cats. Nature 269 (1977) 252-254
3. Ganusov V.V., Bergstrom C.T., and Antia R. Within-host population dynamics and the evolution of microparasites in a heterogeneous host population. Evolution 56 (2002) 213-223
4. Gomes-Keller M.A., Gonczi E., Tandon R., Riondato F., Hofmann-Lehmann R., Meli M.L., and Lutz H. Detection of feline leukemia virus RNA in saliva from naturally infected cats and correlation of PCR results with those of current diagnostic methods. J. Clin. Microbiol. 44 (2006) 916-922
5. Gomes-Keller M.A., Tandon R., Gonczi E., Meli M.L., Hofmann-Lehmann R., and Lutz H. Shedding of feline leukemia virus RNA in saliva is a consistent feature in viremic cats. Vet. Microbiol. 112 (2006) 11-21
6. Hofmann-Lehmann R., Cattori V., Tandon R., Boretti F.S., Meli M.L., Riond B., and Lutz H. How molecular methods change our views of FeLV infection and vaccination. Vet. Immunol. Immunopathol. 124 (2008) 119-123
7. Hofmann-Lehmann R., Cattori V., Tandon R., Boretti F.S., Meli M.L., Riond B., Pepin A.C., Willi B., Ossent P., and Lutz H. Vaccination against the feline leukaemia virus: outcome and response categories and long-term follow-up. Vaccine 25 (2007) 5531-5539
8. Hofmann-Lehmann R., Huder J.B., Gruber S., Boretti F., Sigrist B., and Lutz H. Feline leukaemia provirus load during the course of experimental infection and in naturally infected cats. J. Gen. Virol. 82 (2001) 1589-1596
9. Hofmann-Lehmann R., Tandon R., Boretti F.S., Meli M.L., Willi B., Cattori V., Gomes-Keller M.A., Ossent P., Golder M.C., Flynn J.N., and Lutz H. Reassessment of feline leukaemia virus (FeLV) vaccines with novel sensitive molecular assays. Vaccine 24 (2006) 1087-1094
10. Jarrett O., and Ganiere J.P. Comparative studies of the efficacy of a recombinant feline leukaemia virus vaccine. Vet. Rec. 138 (1996) 7-11
11. Lutz H., Pedersen N.C., and Theilen G.H. Course of feline leukemia virus infection and its detection by enzyme-linked immunosorbent assay and monoclonal antibodies. Am. J. Vet. Res. 44 (1983) 2054-2059
12. McClelland A.J., Hardy W.D., and Zuckerman E.E. Prognosis of healthy feline leukemia virus infected cats. Cancer Res. 4 (1980) 121-126
13. Miyazawa T. Infections of feline leukemia virus and feline immunodeficiency virus. Front. Biosci. 7 (2002) d504-518
14. Onions D. Animal models: lessons from feline and bovine leukaemia virus infections. Leuk. Res. 9 (1985) 709-711
15. Rojko J.L., Hoover E.A., Mathes L.E., Olsen R.G., and Schaller J.P. Pathogenesis of experimental feline leukemia virus infection. J. Natl. Cancer Inst. 63 (1979) 759-768
16. Tandon R., Cattori V., Gomes-Keller M.A., Meli M.L., Golder M.C., Lutz H., and Hofmann-Lehmann R. Quantitation of feline leukaemia virus viral and proviral loads by TaqMan(R) real-time polymerase chain reaction. J. Virol. Methods 130 (2005) 124-132
17. Torres A.N., Mathiason C.K., and Hoover E.A. Re-examination of feline leukemia virus: host relationships using real-time PCR. Virology 332 (2005) 272-283