Discriminant value of % microcytic/% hypochromic ratio in the differential diagnosis of microcytic anemia

Clinical Chemistry and Laboratory Medicine

Volumn 46, Issue 12, 2008, Pages 1752-1758

  Urrechaga, Eloísa ^a  

^a HOSPITAL DE GALDAKAO   (Spain)

Author keywords

thalassemia screening; Erythrocyte discriminant indices; Hypochromia; Iron deficiency anemia; Microcytic anemia differential diagnosis; Microcytosis

Indexed keywords

ADULT; ARTICLE; BETA THALASSEMIA; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; FEMALE; HEMATOLOGICAL PARAMETERS; HUMAN; IRON DEFICIENCY ANEMIA; MAJOR CLINICAL STUDY; MALE; MICROCYTIC ANEMIA; MICROCYTOSIS; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; YOUDEN INDEX;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANEMIA, HYPOCHROMIC; DIAGNOSIS, DIFFERENTIAL; ERYTHROCYTES, ABNORMAL; FEMALE; HUMANS; MALE; MIDDLE AGED; YOUNG ADULT;

EID: 57449114943     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2008.355     Document Type: Article

References (28)

1. Hallberg L. Iron requirements: comments on methods and some crucial concepts in iron nutrition. Bio Trace Elem Res 1992;35:25-45.
2. Bothwell TH, Charlton RW. Iron deficiency in women. Washington, DC: The Nutrition Foundation, 1981.
3. Shine I, Lal S. A strategy to detect beta-thalassemia minor. Lancet 1977;1:692-4.
4. Rund D, Rachmilewitz E. Beta-thalassemia. N Engl J Med 2005;353:1135-46.
5. Angastiniotis M, Modell B. Global epidemiology of hemoglobin disorders. Ann NY Acad Sci 1998;850:251-69.
6. Weatherall DJ, Clegg JB. Inherited haemoglobin disorders: an increasing global health problem. Bull World Health Organ 2001;79:704-12.
7. Galanello R, Eleftheriou A, Traeger-Synodinos J, Old J, Petrou M, Angastiniotis M. Prevention of thalassaemias and other haemoglobin disorders. Nicosia: Thalassemia International Federation, 2003.
8. Modell B, Darlison M, Birgens H, Cario H, Faustino P, Giordano PC, et al. Epidemiology of haemoglobin disorders in Europe: an overview. Scand J Clin Lab Invest 2007;67:39-69.
9. Bentley SA, Ayscue LH, Watson JM, Ross DW. The clinical utility of discriminant functions for the differential diagnosis of microcytic anemias. Blood cells 1989;15:575-82.
10. England JM, Bain BJ, Fraser PM. Differentiation of iron deficiency from thalassaemia trait. Lancet 1973;1:1514.
11. Green R, King R. A new red cell discriminant incorporating volume dispersion for differentiating iron deficiency anemia from thalassemia minor. Blood Cells 1989;5:481-95.
12. Mentzer WC Jr. Differentiation of iron deficiency from thalassaemia trait. Lancet 1973;1:882.
13. Ricerca BM, Storti S, d'Onofrio G, Mancini S, Vittori M, Campisi S, et al. Differentiation of iron deficiency from thalassaemia trait: a new approach. Haematologica 1987;72:409-13.
14. Srivastava PC, Bevington JM. Iron deficiency and/or thalassaemia trait. Lancet 1973;1:832.
15. Brugnara C. 2003 Iron deficiency and erythropoiesis: new diagnostic approaches. Clin Chem 1989;49:1573-8.
16. Tassiopoulos T, Konstantopoulos K, Tassiopoulos S, Rombos Y, Alevizou-Terzaki V, Kyriaki P. Erythropoietin levels and microcytosis in heterozygous beta-thalassemia. Acta Haematol 1997;98:147-9.
17. Giordano PC, Bouva MJ, Harteveld CL. A confidential inquiry estimating the number of patients affected with sickle cell disease and thalassemia major confirms the need for a prevention strategy in the Netherlands. Hemoglobin 2004;28:287-96.
18. Lafferty JD, Crowther MA, Ali MA, Levine M. The evaluation of various mathematical RBC indices and their efficacy in discriminating between thalassemic and non-thalassemic microcytosis. Am J Clin Pathol 1996;106:201-5.
19. Roberts GT, El Badawi SB. Red blood cell distribution width index in some hematologic diseases. Am J Clin Pathol 1985;83:222-6.
20. Jayabose S, Giamelli J, Levondoglu-Tugal O, Sandoval C, Ozkaynak F, Visintainer P. Differentiating iron deficiency anemia from thalassemia minor by using an RDW-based index. J Pediatr Hematol Oncol 1999;21:314.
21. Eldibany MM, Totonchi KF, Joseph NJ, Rhone D. Usefulness of certain red blood cell indices in diagnosing and differentiating thalassemia trait from iron-deficiency anemia. Am J Clin Pathol 1999;111:676-82.
22. Demir A, Yarali N, Fisgin T, Duru F, Kara A. Most reliable indices in differentiation between thalassemia trait and iron deficiency anemia. Pediatr Int 2002;44:612-6.
23. Beyan C, Kaptan K, Ifran A. Predictive value of discrimination indices in differential diagnosis of iron deficiency anemia and beta-thalassemia trait. Eur J Hematol 2007;78:524-6.
24. Ntaios G, Chatzinikolau A, Sauli Z, Girtovitis F, Tsapanidou M, Kaiafa G, et al. Discrimination indices as screening test for b thalassemic trait. Ann Hematol 2007;86:487-91.
25. Ratho DA, Kaur A, Patel V, Patel K, Kabrawala R, Patel V, et al. Usefulness of cell counter-based parameters and formulas in detection of β-thalassemia trait in areas of high prevalence. Am J Clin Pathol 2007;128:585-9.
26. d'Onofrio G, Zini G, Ricerca BM, Mancini S, Mango G. Automated measurement of red blood cell microcytosis and hypochromia in iron deficiency and beta-thalassemia trait. Arch Pathol Lab Med 1992;116:84-9.
27. Robertson EP, Pollock A, Yau KS, Chan CL. Use of Technicon H*1 technology in routine thalassemia screening. Med Lab Sci 1992;49:259-64.
28. Jiménez CV, Minchinela J, Ros J. New indices from the H*2 analyser improve differentiation between heterozygous beta or delta beta thalassaemia and iron deficiency anaemia. Clin Lab Haem 1995;17:151-5.