Cerebrospinal S100-B: A potential marker for progressive intracranial hemorrhage in patients with severe traumatic brain injury

European Journal of Medical Research

Volumn 13, Issue 11, 2008, Pages 511-516

  Kirchhoff, Chlodwig ^a   Buhmann, S ^b   Braunstein, V ^b   Leidel, B A ^b   Vogel, T ^d   Kreimeier, U ^c   Mutschler, W ^b   Biberthaler, P ^b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

^d ST JOSEF HOSPITAL   (Germany)

Author keywords

Blood brain barrier; Cerebrospinal fluid; S100 B; Traumatic brain injury

Indexed keywords

ALBUMIN; PROTEIN S100B;

ADULT; ALBUMIN BLOOD LEVEL; ARTICLE; BLOOD ANALYSIS; BRAIN HEMORRHAGE; BRAIN SCINTISCANNING; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIAGNOSTIC KIT; DISEASE ASSOCIATION; DISEASE MARKER; DISEASE SEVERITY; FEMALE; HUMAN; MALE; PROTEIN ANALYSIS; PROTEIN CEREBROSPINAL FLUID LEVEL; QUANTITATIVE ANALYSIS; TRAUMATIC BRAIN INJURY;

ADULT; BIOLOGICAL MARKERS; BLOOD-BRAIN BARRIER; DISEASE PROGRESSION; DIURETICS, OSMOTIC; FEMALE; HUMANS; INTRACRANIAL HEMORRHAGE, TRAUMATIC; INTRACRANIAL PRESSURE; MALE; MANNITOL; MIDDLE AGED; NERVE GROWTH FACTORS; S100 PROTEINS; SEVERITY OF ILLNESS INDEX;

EID: 57449113398     PISSN: 09492321     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Biberthaler P, Mussack T, Kanz KG, Linsenmaier U, Pfeifer KJ, Mutschler W, Jochum M. [Identification of high-risk patients after minor craniocerebral trauma. Measurement of nerve tissue protein S 100]. Unfallchirurg. 2004; 107: 197-202.
2. Biberthaler P, Mussack T, Wiedemann E, Kanz KG, Mutschler W, Linsenmaier U, Pfeifer KJ, Gippner-Steppert C, Jochum M. Rapid identification of high-risk patients after minor head trauma (MHT) by assessment of S-10OB: ascertainment of a cut-off level. Eur J Med Res. 2002; 7: 164-170.
3. Biberthaler P, Linsenmeier U, Pfeifer K-J, Kroetz M, Mussack T, Kanz K-G, Hoecherl EFJ, Jonas F, Marzi I, Leucht P, Jochum M, Mutschler W. Serum S-100B Concentration provides additional information for the indication of computed tomography in patients after minor head injury: a prospective mulitcenter study. Shock. 2006; 25: 446-453.
4. Chesnut RM, Marshall LF, Klauber MR, Blunt BA, Baldwin N, Eisenberg HM, Jane JA, Marmarou A, Foulkes MA. The role of secondary brain injury in determining outcome from severe head injury. J Trauma. 1993; 34: 216-222.
5. Farin A, Marshall LF. Lessons from epidemiologic studies in clinical trials of traumatic brain injury. Acta Neurochir Suppl. 2004; 89: 101-107.
6. Ghanem G, Loir B, Morandini R, Sales F, Lienard D, Eggermont A, Lejeune F. On the release and half-life of S100B protein in the peripheral blood of melanoma patients. Int J Cancer. 2001; 94: 586-590.
7. Hayakata T, Shiozaki T, Tasaki O, Ikegawa H, Inoue Y, Toshiyuki F, Hosotubo H, Kieko F, Yamashita T, Tanaka H, Shimazu T, Sugimoto H. Changes in CSF S100B and cytokine concentrations in early-phase severe traumatic brain injury. Shock. 2004; 22: 102-107.
8. Hukkelhoven CW, Steyerberg EW, Rampen AJ, Farace E, Habbema JD, Marshall LF, Murray GD, Maas AI. Patient age and outcome following severe traumatic brain injury: an analysis of 5600 patients. J Neurosurg. 2003; 99: 666-673.
9. Kogel D, Peters M, Konig HG, Hashemi SM, Bui NT, Arolt V, Rothermundt M, Prehn JH. S100B potently activates p65/c-Rel transcriptional complexes in hippocampal neurons: Clinical implications for the role of S100B in excitotoxic brain injury. Neuroscience. 2004; 127: 913-920.
10. Krotz M, Linsenmaier U, Kanz KG, Pfeifer KJ, Mutschler W, Reiser M. Evaluation of minimally invasive percutaneous CT-controlled ventriculostomy in patients with severe head trauma. Eur Radiol. 2004; 14: 227-233.
11. Lobato RD, Gomez PA, Alday R, Rivas JJ, Dominguez J, Cabrera A, Turanzas FS, Benitez A, Rivero B. Sequential computerized tomography changes and related final outcome in severe head injury patients. Acta Neurochir (Wien). 1997; 139: 385-391.
12. Marchi N, Rasmussen P, Kapural M, Fazio V, Kight K, Mayberg MR, Kanner A, Ayumar B, Albensi B, Cavaglia M, Janigro D. Peripheral markers of brain damage and blood-brain barrier dysfunction. Restor Neurol Neurosci. 2003; 21: 109-121.
13. Marshall LF, Marshall SB, Klauber MR, Clark MV, Eisenberg HM, Jane JA, Luerssen TG, Marmarou A, Foulkes MA. A new classification of head injury based on computerized tomography. J Neurosurg Suppl. 1991; 75: 14-20.
14. Marshall LF, Becker DP, Bowers SA, Cayard C, Eisenberg H, Gross CR, Grossman RG, Jane JA, Kunitz SC, Rimel R, Tabaddor K, Warren J. The National Traumatic Coma Data Bank. Part 1: Design, purpose, goals, and results. J Neurosurg. 1983; 59: 276-284.
15. Mussack T, Kirchhoff C, Buhmann S, Biberthaler P, Ladurner R, Gippner-Steppert C, Mutschler W, Jochum M. Significance of Elecsys® S100 serum levels for real-time assessment of traumatic brain damage in multiple trauma patients. Clin Chem Lab Med. 2006; 44: 45-49.
16. Nortje J, Menon DK. Traumatic brain injury: physiology, mechanisms, and outcome. Curr Opin Neurol. 2004; 17, 711-718.
17. Oertel M, Kelly DF, McArthur D, Boscardin WJ, Glenn TC, Lee JH, Gravori T, Obukhov D, McBride DQ, Martin NA. Progressive hemorrhage after head trauma: predictors and consequences of the evolving injury. J Neurosurg. 2002; 96: 109-116.
18. Otto M, Stein H, Szudra A, Zerr I, Bodemer M, Gefeller O, Poser S, Kretzschmar HA, Mader M, Weber T. S-100 protein concentration in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease. J Neurol. 1997; 244: 566-570.
19. Otto VI, Heinzel-Pleines UE, Gloor SM, Trentz O, Kossmann T, Morganti-Kossmann MC. sICAM-1 and TNF-alpha induce MIP-2 with distinct kinetics in astrocytes and brain microvascular endothelial cells. J Neurosci Res. 2000; 60: 733-742.
20. Pleines UE, Morganti-Kossmann MC, Rancan M, Joller H, Trentz O, Kossmann T. S-100 beta reflects the extent of injury and outcome, whereas neuronal specific enolase is a better indicator of neuroinflammation in patients with severe traumatic brain injury. J Neurotrauma. 2001; 18: 491-498.
21. Raabe A, Grolms C, Keller M, Dolmert J, Sorge O, Seifert V. Correlation of computed tomography findings and serum brain damage markers following severe head injury. Acta Neurochir. 1998; 140: 787-792.
22. Raabe A, Kopetsch O, Woszczyk A, Lang J, Gerlach R, Zimmermann M, Seifert V. Serum S-100B protein as a molecular marker in severe traumatic brain injury. Restor Neurol Neurosci. 2003; 21: 159-169.
23. Reiber H. Dynamics of brain-derived proteins in cerebrospinal fluid. Clin Chim Acta. 2001; 310: 173-186.
24. Reiber H, Felgenhauer K. Protein transfer at the blood cerebrospinal fluid barrier and the quantitation of the humoral immune response within the central nervous system. Clin Chim Acta. 1987; 163: 319-328.
25. Rothermundt M, Peters M, Prehn JH, Arolt V. S100B in brain damage and neurodegeneration. Microsc Res Tech. 2003; 60: 614-632.
26. Servadei F, Nasi MT, Giuliani G, Cremonini AM, Cenni P, Zappi D, Taylor GS. CT prognostic factors in acute subdural haematomas: the value of the 'worst' CT scan. Br J Neurosurg. 2000; 14: 110-116.
27. Sindic CJ, Chalon MP, Cambiaso CL, Laterre EC, Masson PL. Assessment of damage to the central nervous system by determination of S-100 protein in the cerebrospinal fluid. J Neurol Neurosurg Psychiatry. 1982; 45: 1130-1135.
28. Stein SC, Spettell C, Young G, Ross SE. Delayed and progressive brain injury in closed-head trauma: radiological demonstration. Neurosurgery. 1993; 32: 25-30.
29. The Brain Trauma Foundation The Brain Trauma Foundation. The American Association of Neurological Surgeons. The Joint Section on Neurotrauma and Critical Care. Recommendations for intracranial pressure monitoring technology. J Neurotrauma. 2000; 17: 497-506.
30. Ucar T, Baykal A, Akyuz M, Dosemeci L, Toptas B. Comparison of serum and cerebrospinal fluid protein S-100b levels after severe head injury and their prognostic importance. J Trauma. 2004; 57: 95-98.