Evening primrose oil is effective in atopic dermatitis: A randomized placebo-controlled trial

Indian Journal of Dermatology, Venereology and Leprology

Volumn 74, Issue 5, 2008, Pages 447-452

  Senapati, Swapan ^a   Banerjee, Sabyasachi ^a,b   Gangopadhyay, Dwijendra ^a  

^a CALCUTTA NATIONAL MEDICAL COLLEGE   (India)

^b NONE   (India)

Author keywords

Atopic dermatitis; Evening primrose oil; Gamma linolenic acid

Indexed keywords

ALPHA TOCOPHEROL; GAMMA LINOLENIC ACID; PLACEBO; PRIMROSE OIL; SUNFLOWER OIL;

ABSENCE OF SIDE EFFECTS; ADOLESCENT; ADULT; ARTICLE; ATOPIC DERMATITIS; CHILD; CLINICAL ASSESSMENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG CAPSULE; DRUG EFFICACY; DRUG SAFETY; DRY SKIN; FEMALE; HUMAN; INDIA; INFANT; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; OUTPATIENT DEPARTMENT; PARAMETER; PRESCHOOL CHILD; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SCORING SYSTEM; SKIN MANIFESTATION; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME;

EID: 57449099047     PISSN: 03786323     EISSN: None     Source Type: Journal    
DOI: 10.4103/0378-6323.42645     Document Type: Article

References (22)

1. Gangopadhyay DN, Naskar B, Roy AK. Atopic dermatitis and ABO blood group. Indian J Dermatol 2006;51:33-5.
2. Bradley M, Kockum I, Soderhall C, Van Hage-Hamsten M, Luthman H, Nordenskjöld M, et al. Characterization by phenotype of families with atopic dermatitis. Acta Dermatol Venerol 2000;80:106-10.
3. Hanifin JM, Rajka RG. Diagnostic features of atopic dermatitis. Acta Dermatol Venereol 1980;92:S44-7.
4. Williums HC. Is the prevalence of atopic dermatitis increasing? Clin Exp Dermatol 1992;17:385-91.
5. Hansen AE. Serum lipids in eczema and other pathological conditions. Am J Dis Child 1937;53:933-46.
6. Wright S, Horrobin D, Manku M. Deficient conversion of linoleic acid. J Am Acad Dermatol 1990;23:533-4.
7. Heiduschka A, Luft K. The fat and oil in seeds of Oenotheria biennis and one new linoleic acid. Archiv Der Pharmazie 1919;257:33-69.
8. Horrobin DF. Essential fatty acid metabolism and its modification in atopic eczema. Am J Clin Nutr 2000; 71:S367-72.
9. Belch JJ, Hill A. Evening primrose oil and borage oil in rheumatologic conditions. Am J Clin Nutr 2000;71:S352-6.
10. Millar JH, Zilkha KJ, Longman MJ, Wright HP, Smith AD, Belin J, et al. Double blind trial of linoleate supplementation of the diet in multiple sclerosis. BMJ 1973;31:765-8.
11. Fiocchi A, Sala M, Sognoroni P, Banderali G, Agostoni C, Riva E. The efficacy and safety of gammalinoleic acid in the treatment of infantile atopic dermatitis. J Int Med Res 1994;22:24-32.
12. Kercher MJ, Korting HC. Treatment of atopic eczema with evening primrose oil: Rationale and clinical results. Clin Investig 1992;70:167-71.
13. Bordoni A, Biagi PL, Mase M , Ricci G, Fanelli C, Patrizi AC, et al. Evening primrose oil (Efamol) in the treatment of children with atopic eczema. Drug Exp Clin Res 1988;14:291-7.
14. Andreassi M, Forleo P, Di Lorio A, Masci S, Abate G, Amerio P. Efficacy of gamma-linolenic acid in the treatment of patients with atopic dermatitis. J Int Med Res 1997;25: 266-74.
15. Yoon S, Lee J, Lee S. The therapeutic effect of evening primrose oil in atopic dermatitis patients with dry scaly skin lesions is associated with the normalization of serum gamma-interferon levels. Skin Pharmacol Appl Skin Physiol 2002;15:20-5.
16. Morse PF, Horrobin DF, Manku MS, Stewart C, Allen R, Littlewood S, et al. Meta analysis of placebo controlled studies of the efficacy of Epogram in the treatment of atopic eczema;relationship between plasma essential fatty acid changes and clinical response. Br J Dermatol 1989;121:75-90.
17. van Gool CJ, Zeegers MP, Thijs C. Oral essential fatty acid supplementation in atopic dermatitis: A meta-analysis of placebo-controlled trials. Br J Dermatol 2004;150:728-40.
18. Berth-Jones J, Graham-Brown RA. Placebo controlled trial of essential fatty acid supplementation in atopic dermatitis. Lancet 1993;341:1557-60.
19. Callaway J, Schwab U, Harvima I, Halonen P, Mykkänen O, Hyvönen P, et al. Efficacy of dietary hempseed oil in patients with atopic dermatitis. J Dermatol Treat 2005;16:87-94.
20. Takwale A, Tan E, Agarwal S, Barclay G, Ahmed I, Hotchkiss K, et al. Efficacy and tolerability of borage oil in adults and children with atopic eczema: Randomised, double blind, placebo controlled, parallel group trial. BMJ 2003;327:1358-9.
21. van Gool CJ, Thijs C, Dagnelie PC, Henquet CJ, van Houwelingen AC, Schrander J, et al. Gamma-linolenic acid supplementation for prophylaxis of atopic dermatitis: A randomized controlled trial in infants at high familial risk. Am J Clin Nutr 2003;77:943-51.
22. Morse NL, Clough PM. A meta-analysis of randomized, placebo-controlled clinical trials of Efamol evening primrose oil in atopic eczema: Where do we go from here in light of more recent discoveries? Curr Pharm Biotechnol 2006;7:503-24.