A study on the ALAD gene polymorphisms associated with lead exposure

Toxicology and Industrial Health

Volumn 24, Issue 7, 2008, Pages 501-506

  Shaik, Ap ^a   Jamil, K ^a  

^a Bhagwan Mahavir Medical Research Centre   (India)

Author keywords

ALAD gene polymorphism; blood lead levels; heme synthesis; lead toxicity

Indexed keywords

HEMOGLOBIN; LEAD;

ADULT; ALLELE; ANODIC STRIPPING POTENTIOMETRY; ARTICLE; BATTERY INDUSTRY; CONTROL GROUP; CONTROLLED STUDY; DNA POLYMORPHISM; ENVIRONMENTAL EXPOSURE; FEMALE; GENE; GENOTYPE; HEMATOLOGICAL PARAMETERS; HEMOGLOBIN BLOOD LEVEL; HUMAN; INDIA; INDUSTRIAL WORKER; LEAD BLOOD LEVEL; LEAD POISONING; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MATERIALS; OCCUPATIONAL HAZARD; POLYMERASE CHAIN REACTION; PORPHOBILINOGEN SYNTHASE 1-2 GENE; PORPHOBILINOGEN SYNTHASE 2-2 GENE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; THROMBOCYTE COUNT;

ADOLESCENT; ADULT; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HEMOGLOBINS; HUMANS; INDIA; LEAD; LEAD POISONING; MALE; MIDDLE AGED; OCCUPATIONAL EXPOSURE; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PORPHOBILINOGEN SYNTHASE; YOUNG ADULT;

EID: 57449097212     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1177/0748233708095770     Document Type: Article

References (29)

1. Astrin KH, Bishop DF, Wetmur JG, Kaul BC, Davidow B, Desnick RJ (1987) Aminolevulinic acid dehydratase isozymes and lead toxicity. Ann NY Acad Sci 514: 23–29.
2. ATSDR (1993) Toxicological Profile for Lead, TP- 92/12. Atlanta, GA: Agency for Toxic Substances and Disease Registry.
3. Barton JC, Patton MA, Edwards CQ, Griffen LM, Kushner JP, Meeks RG (1994) Blood lead concentrations in hereditary hemochromatosis. J Lab Clin Med 124: 193–198.
4. Bergdahl IA (1998) Lead-binding proteins – a way to understand lead toxicity? Metals and Biomolecules. Analusis 26: 81–83.
5. Bressler JP, Goldstein GW (1991) Mechanisms of lead toxicity. Biochem Pharmacol 41: 479–484.
6. Fleming DE, Chettle DR, Wetmur JG, Desnick RJ, Robin JP, Boulay D (1998) Effect of the d- aminolevulinate dehydratase polymorphism on the accumulation of lead in bone and blood in lead smelter workers. Environ Res 77: 49–61.
7. Fu H, Boffetta P (1995) Cancer and occupational exposure to inorganic lead compounds: a meta-analysis of published data. Occup Environ Med 52: 73–81.
8. Hu H, Wu MT, Cheng Y, Sparrow D, Weiss S, Kelsey K (2001) The delta-aminolevulinic acid dehydratase (ALAD) polymorphism and bone and blood lead levels in community-exposed men: the Normative Aging Study. Environ Health Perspect 109: 827–832.
9. Jaffe EK (2000) The porphobilinogen synthase family of metalloenzymes. Acta Crystallogr D Biol Crystallogr 56: 115–128.
10. Kelada SN, Shelton E, Kaufmann RB, Khoury MJ (2001) Delta aminolevulinic acid dehydratase genotype and lead toxicity: a HuGE review. Am J Epidemiol 154: 1–13.
11. Mahaffey KR (1995) Nutrition and lead: strategies for public health. Environ Health Perspect 103: 191–196.
12. Montenegro MF, Barbosa F, Sandrim VC, Gerlach RF, Tanus-Santos JE (2006a) A polymorphism in the delta-aminolevulinic acid dehydratase gene modifies plasma/whole blood lead ratio. Arch Toxicol 80: 394–398.
13. Montenegro MF, Barbosa F, Sandrim VC, Gerlach RF, Tanus-Santos JE (2006b) Ethnicity affects the distribution of delta-aminolevulinic acid dehydratase (ALAD) genetic variants. Clin Chim Acta 367: 192–195.
14. Montenegro MF, Barbosa F, Tanus-Santos JE (2008) Assessment of how pregnancy modifies plasma lead and plasma/whole blood lead ratio in ALAD 1-1 genotype women. Basic Clin Pharmacol Toxicol 102: 347–351.
15. NTP (2003) Report on Carcinogens (RoC) Background Document for Lead and Lead Compounds. National Toxicology Program (http://ntp-server.niehs.nih.gov/newhomeroc/roc11/Lead-Public.pdf).
16. Onalaja AO, Claudio L (2000) Genetic susceptibility to lead poisoning. Environ Health Perspect 108: 23–26.
17. Rezende VB, Barbosa F, Montenegro MF, Sandrim VC, Gerlach RF, Tanus-Santos JE (2007) An interethnic comparison of the distribution of vitamin D receptor genotypes and haplotypes. Clin Chim Acta 384: 155–159.
18. Rezende VB, Barbosa F, Montenegro MF, Sandrim VC, Gerlach RF, Tanus-Santos JE (2008) Haplotypes of vitamin D receptor modulate the circulating levels of lead in exposed subjects. Arch Toxicol 82: 29–36.
19. Schwartz BS, Lee BK, Stewart W, Ahn KD, Springer K, Kelsey K (1995) Associations of D- aminolevulinic acid dehydratase genotype with plant, exposure duration, and blood lead and zinc protoporphyrin levels in Korean lead workers. Am J Epidemiol 1142: 738–745.
20. Shaik AP, Siva S, Reddy SC, Das PG, Jamil K (2006) Lead-induced genotoxicity in lymphocytes from peripheral blood samples of humans: in vitro studies. Drug Chem Toxicol 29: 111–124.
21. Shen XM, Wu SH, Yan CH, Zhao W, Ao LM, Zhang YW (2001) Delta-aminolevulinate dehydratase polymorphism and blood lead levels in Chinese children. Environ Res 85: 185–190.
22. Smith CM, Wang X, Hu H, Kelsey KT (1995) A polymorphism in the delta-aminolevulinic acid dehydratase gene may modify the pharmacokinetics and toxicity of lead. Environ Health Perspect 103: 248–253.
23. Steenland K, Boffetta P (2000) Lead and cancer in humans: where are we now? Am J Ind Med 38: 295–299.
24. Suzen HS, Duydu Y, Aydin A, Isimer A, Vural N (2003) Influence of the delta-aminolevulinic acid dehydratase (ALAD) polymorphism on biomarkers of lead exposure in Turkish storage battery manufacturing workers. Am J Ind Med 43: 165–171.
25. Suzen HS; Duydu Y; Aydyn A; (2004) Molecular analysis of aminolevulinic acid dehydratase (ALAD) gene polymorphism in a Turkish population. Biochem Genet 42: 11–12.
26. Warren MJ, Cooper JB, Wood SP, Shoolingin-Jordan PM (1998) Lead poisoning, haem synthesis and 5-aminolaevulinic acid dehydratase. Trends Biochem Sci 23: 217–221.
27. Wetmur JG, Bishop DF, Cantelmo C, Desnick RJ (1986) Human delta-aminolevulinate dehydratase: nucleotide sequence of a full-length cDNA clone. Proc Natl Acad Sci 83: 7703–7707.
28. Wetmur JG, Kaya AH, Plewinska M, Desnick RJ (1991a) Molecular characterization of the human delta-aminolevulinic acid dehydratase 2 (ALAD2) allele: implications for molecular screening of individuals for genetic susceptibility to lead poisoning. Am J Hum Genet 49: 757–763.
29. Wetmur JG, Lehnert G, Desnick RJ (1991b) The delta-aminolevulinate dehydratase polymorphism: higher blood lead levels in lead workers and environmentally exposed children with the 1-2 and 2-2 isozymes. Environ Res 56: 109–119.