Development and validation of a high-performance liquid chromatography assay for posaconazole utilizing solid-phase extraction

Clinical Chemistry and Laboratory Medicine

Volumn 46, Issue 12, 2008, Pages 1747-1751

  Störzinger, Dominic ^a   Swoboda, Stefanie ^a   Lichtenstern, Christoph ^a   Müller, Carsten ^b   Weigand, Markus A ^a   Hoppe Tichy, Torsten ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

Author keywords

Analytics; Antifungal agents; Posaconazole; Reversed phase chromatography; Solid phase extraction

Indexed keywords

CLOTRIMAZOLE; POSACONAZOLE;

ACCURACY; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG MONITORING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; SOLID PHASE EXTRACTION; VALIDATION STUDY;

ANTIBIOTICS, ANTIFUNGAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; TRIAZOLES;

EID: 57449096744     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2008.338     Document Type: Article

References (15)

1. Störzinger D, Lichtenstern C, Swoboda S, Weigand MA, Hoppe-Tichy T. Posaconazole in intensive care patients I: invasive fungal infections in surgical intensive care and case presentation. Mycoses 2008;51(Suppl 2):52-7.
2. Walsh TJ, Raad I, Patterson TF, Chandrasekar P, Donowitz GR, Graybill R. Treatment of invasive Aspergillosis with posaconazole in patients who are refractory or intolerant of conventional therapy: an externally controlled trial. Clin Infect Dis 2007;44:2-12.
3. Keating GM. Posaconazole. Drugs 2005;11:1553-67.
4. Gubbins PO, Krishna G, Sansone-Parsons A, Penzak SR, Dong L, Martinho M, et al. Pharmacokinetics and safety of oral posaconazole in stem cell transplant recipients. Antimicrob Agents Chemother 2006;50:1993-9.
5. Courtney R, Pai S, Laughlin M, Lim J, Batra V. Pharmacokinetics, safety, and tolerability of oral posaconazole administered in single and multiple doses in healthy adults. Antimicrob Agents Chemother 2003;47:2788-95.
6. Courtney R, Radwanski E, Lim J, Laughlin M. Pharmacokinetics of posaconazole coadministered with antacid in fasting or nonfasting healthy men. Antimicrob Agents Chemother 2004;48:804-8.
7. Wexler D, Courtney R, Richards W, Banfield Lim J, Laughlin M. Effect of posaconazole on cytochrome P450 enzymes: a randomised, open-label, two-way cross over study. Eur J Pharmaceut Sci 2004;21:645-53.
8. Lampe D, Kreutzberg S, Prumke HJ. Therapeutic drug monitoring of itraconazole - a report of experiences. Mycoses 1994;37:34-9.
9. Andes D, Marchillo K, Conklin R, Krishna G, Ezzet F, Cacciapuoti A, et al. Pharmacodynamics of a new triazole, posaconazole, in a murine model of disseminated candidiasis. Antimicrob Agents Chemother 2004;48:137-42.
10. Andes D, Marchillo K, Stamstad T, Conklin R. In vivo pharmacokinetics and pharmacodynamics of a new triazole, voriconazole, in a murine candidiasis model. Antimicrob Agents Chemother 2003;47:3165-9.
11. Petraitiene R, Petraitis V, Groll AH, Sein T, Piscitelli S, Candelario M, et al. Antifungal activity and pharmacokinetics of posaconazole (SCH 56592) in treatment and prevention of experimental invasive pulmonary aspergillosis: correlation with galactomannan antigenemia. Antimicrob Agents Chemother 2001;45:857-69.
12. Guidance for Industry, Bioanalytical Method Validation. U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), Center for Veterinary Medicine (CVM), May 2001.
13. Müller C, Arndt M, Queckenberg C, Cornely OA, Theisohn M. HPLC analysis of the antifungal agent posaconazole in patients with haematological diseases. Mycoses 2006;49(Suppl 1):17-22.
14. Chhun S, Rey E, Tran A, Lortholary O, Pons G, Jullien V. Simultaneous quantification of voriconazole and posaconazole in human plasma by high-performance liquid chromatography with ultra-violet detection. J Chromatogr B 2007;852:223-8.
15. Shen JX, Tama CI, Hayes RN. Evaluation of automated micro solid phase extraction tips (μ-SPE) for the validation of a LC-MS/MS bioanalytical method. J Chromatogr B 2006;843:275-82.