Urinary metabolite quantification employing 2D NMR spectroscopy

Analytical Chemistry

Volumn 80, Issue 23, 2008, Pages 9288-9297

  Gronwald, Wolfram ^a   Klein, Matthias S ^a   Kaspar, Hannelore ^a   Fagerer, Stephan R ^a   Nürnberger, Nadine ^a   Dettmer, Katja ^a   Bertsch, Thomas ^b   Oefner, Peter J ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b KLINIKUM NÜRNBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTE; BIOLOGICAL FLUIDS; CALIBRATION CURVES; COLORIMETRIC MEASUREMENTS; GAS CHROMATOGRAPHY-MASS SPECTROMETRIES; HETERONUCLEAR; INBORN ERRORS OF METABOLISMS; LOWER LIMITS OF DETECTIONS; METHYL GROUPS; MICROMOLAR RANGES; NATURAL ABUNDANCES; NMR DATUMS; NMR SPECTROSCOPIES; NOVEL METHODS; QUANTUM CORRELATIONS; TISSUE EXTRACTS; TYPICAL APPLICATIONS; URINARY METABOLITES;

AMINES; AMINO ACIDS; ANIMAL CELL CULTURE; BIOCHEMISTRY; BIOMOLECULES; BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROCARBONS; LIQUID CHROMATOGRAPHY; MAGNETIC RESONANCE; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLITES; NUCLEAR MAGNETIC RESONANCE; ORGANIC ACIDS; SPECTROMETERS; SPECTROMETRY; SPECTRUM ANALYSIS;

NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

1 METHYLHISTIDINE; 3 AMINO 2 METHYLPROPIONIC ACID; 3 METHYLHISTIDINE; ACETIC ACID; ALANINE; AMINO ACID; ARGININE; BETAINE; CITRIC ACID; CREATININE; ETHANOLAMINE; GLUTAMINE; GLYCINE; HIPPURIC ACID; HISTIDINE; HISTIDINE DERIVATIVE; LYSINE; METHYL GROUP; OXIDE; TAURINE; TRIMETHYL N OXIDE; UNCLASSIFIED DRUG;

ARTICLE; CALIBRATION; CARBON NUCLEAR MAGNETIC RESONANCE; COLORIMETRY; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HUMAN; HUMAN EXPERIMENT; INBORN ERROR OF METABOLISM; LIQUID CHROMATOGRAPHY; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; METABOLITE; NORMAL HUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; URINE LEVEL;

AMINO ACIDS; CITRIC ACID; CREATININE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HIPPURATES; HUMANS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; URINE;

EID: 57449094403     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac801627c     Document Type: Article

References (18)

1. Holmes, E.; Foxall, P. J. D.; Spraul, M.; Farrant, R. D.; Nicholson, J. K.; Lindon, J. C. J. Pharm. Biomed. Anal. 1997, 15, 1647-59.
2. Weljie, A. M.; Newton, J.; Mercier, P.; Carlson, E.; Slupsky, C. M. Anal. Chem. 2006, 78, 4430-42.
3. Adosraku, R. K.; Ghoi, G. T. Y.; Constantiou-Koktos, V.; Anderson, M. M.; Gibbons, W. A. J. Lipid Res. 1994, 35, 1925-31.
4. Tang, H.; Wang, Y.; Nicholson, J. K.; Lindon, J. C. Anal. Biochem. 2003, 325, 260-72.
5. Zheng, M.; Lu, P.; Liu, Y.; Pease, J.; Usuka, J.; Liao, G.; Peltz, G. Bioinformatics 2007.
6. Hu, F.; Furihata, K.; Kato, Y.; Tanokura, M. J. Agric. Food Chem. 2007, 4307-11.
7. Lewis, I. A.; Schommer, S. C.; Hodis, B.; Robb, K. A.; Tonelli, M.; Westler, W. M.; Sussman, M. R.; Markley, J. L. Anal. Chem. 2007, 79, 9385-90.
8. Shanaiah, N.; Desilva, M. A.; Gowda, G. A. N.; Raftery, M. A.; Hainline, B. E.; Raftery, D. Proc. Natl. Acad. Sci. U. S. A. 2007, 104, 11540-4.
9. Kaspar, H.; Dettmer, K.; Gronwald, W.; Oefner, P. J. J. Chromatogr., B 2008, 870, 222-32.
10. Beckonert, O.; Keun, H. C.; Ebbels, T. M. D.; Bundy, J.; Holmes, E.; Lindon, J. C.; Nicholson, J. K. Nat. Protocols 2007, 2, 2692-702.
11. Seavey, B. R.; Farr, E. A.; Westler, W. M.; Markley, J. L. J. Biomol. NMR 1991, 1, 217-36.
12. Guidance for Industry. Bioanalytical Method Validation, Center for Drug Evaluation and Research, U.S. Department of Health and Human Services: Rockville, MD, 2001.
13. Bland, J. M.; Altman, D. G. Lancet 1986, 327, 307-10.
14. Peake, M.; Whiting, M. Clin. Biochem. Rev. 2006, 27, 173-84.
15. Holmes, E.; Loo, R. L.; Stamler, J.; Bictash, M.; Yap, I. K. S.; Chan, Q.; Ebbels, T.; De Iorio, M.; Brown, I. J.; Veselkov, K. A.; Daviglus, M. L.; Kesteloot, H.; Ueshima, H.; Zhao, L.; Nicholson, J. K.; Elliott, P. Nature 2008, 453, 396-400.
16. Constantinou, M. A.; Papakonstantinou, E.; Spraul, M.; Sevastiadou, S.; Costalos, C.; Koupparis, M. A.; Shulpis, K.; Tsantili-Kakoulidou, A.; Mirkos, E. Anal. Chim. Acta 2005, 542, 169-77.
17. Neild, G. H.; Foxall, P. J. D.; Lindon, J. C.; Holmes, E. C.; Nicholson, J. K. Nephrol. Dial. Transplant. 1997, 12, 404-17.
18. Wissenschaftliche Tabellen Geigy; CIBA-GEIGY AG: Basel, Switzerland, 1983.