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Volumn 30, Issue 10, 2008, Pages 1039-1046

The application of viral vectors to enhance regeneration after peripheral nerve repair

Author keywords

Nerve regeneration; Nerve repair; Peripheral nerve; Viral vectors

Indexed keywords

ADENOVIRUS VECTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; DNA; DOXYCYCLINE; FIBROBLAST GROWTH FACTOR 2; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; HERPES SIMPLEX VIRUS VECTOR; LENTIVIRUS VECTOR; NERVE GROWTH FACTOR; NEUROTROPHIC FACTOR; NEUROTROPHIN 3; NEUROTROPHIN 4; PARVOVIRUS VECTOR; RECOMBINANT NERVE GROWTH FACTOR; RETROVIRUS VECTOR; TETRACYCLINE; UNCLASSIFIED DRUG; VIRUS VECTOR;

EID: 57449089045     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1179/174313208X362514     Document Type: Review
Times cited : (20)

References (58)
  • 1
    • 0036135141 scopus 로고    scopus 로고
    • Is the therapeutic application of neurotrophic factors dead?
    • Apfel SC. Is the therapeutic application of neurotrophic factors dead? Ann Neurol 2002; 51: 8-11
    • (2002) Ann Neurol , vol.51 , pp. 8-11
    • Apfel, S.C.1
  • 2
    • 0034328085 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant human nerve growth factor in patients with diabetic polyneuropathy: A randomized controlled trial. rhNGF Clinical Investigator Group
    • Apfel SC, Schwartz S, Adornato BT, et al. Efficacy and safety of recombinant human nerve growth factor in patients with diabetic polyneuropathy: A randomized controlled trial. rhNGF Clinical Investigator Group. JAMA 2000; 284: 2215-2221
    • (2000) JAMA , vol.284 , pp. 2215-2221
    • Apfel, S.C.1    Schwartz, S.2    Adornato, B.T.3
  • 3
    • 32444438913 scopus 로고    scopus 로고
    • Adenoviral GDNF gene transfer enhances neurofunctional recovery after recurrent laryngeal nerve injury
    • Araki K, Shiotani A, Watabe K, et al. Adenoviral GDNF gene transfer enhances neurofunctional recovery after recurrent laryngeal nerve injury. Gene Ther 2006; 13: 296-303
    • (2006) Gene Ther , vol.13 , pp. 296-303
    • Araki, K.1    Shiotani, A.2    Watabe, K.3
  • 4
    • 2642526164 scopus 로고    scopus 로고
    • VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model
    • Azzouz M, Ralph GS, Storkebaum E, et al. VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model. Nature 2004; 429: 413-417
    • (2004) Nature , vol.429 , pp. 413-417
    • Azzouz, M.1    Ralph, G.S.2    Storkebaum, E.3
  • 5
    • 33748421222 scopus 로고    scopus 로고
    • GDNF gene delivery via the p75(NTR) receptor rescues injured motor neurons
    • Barati S, Hurtado PR, Zhang SH, et al. GDNF gene delivery via the p75(NTR) receptor rescues injured motor neurons. Exp Neurol 2006; 202: 179-188
    • (2006) Exp Neurol , vol.202 , pp. 179-188
    • Barati, S.1    Hurtado, P.R.2    Zhang, S.H.3
  • 6
    • 19444371789 scopus 로고    scopus 로고
    • Regulated lentiviral NGF gene transfer controls rescue of medial septal cholinergic neurons
    • Blesch A, Conner J, Pfeifer A, et al. Regulated lentiviral NGF gene transfer controls rescue of medial septal cholinergic neurons. Mol Ther 2005; 11: 916-925
    • (2005) Mol Ther , vol.11 , pp. 916-925
    • Blesch, A.1    Conner, J.2    Pfeifer, A.3
  • 7
    • 0036456604 scopus 로고    scopus 로고
    • Spontaneous and neurotrophin-induced axonal plasticity after spinal cord injury
    • Blesch A, Tuszynski MH. Spontaneous and neurotrophin-induced axonal plasticity after spinal cord injury. Prog Brain Res 2002; 137: 415-423
    • (2002) Prog Brain Res , vol.137 , pp. 415-423
    • Blesch, A.1    Tuszynski, M.H.2
  • 8
    • 34848866015 scopus 로고    scopus 로고
    • Transient growth factor delivery sustains regenerated axons after spinal cord injury
    • Blesch A, Tuszynski MH. Transient growth factor delivery sustains regenerated axons after spinal cord injury. J Neurosci 2007; 27: 10535-10545
    • (2007) J Neurosci , vol.27 , pp. 10535-10545
    • Blesch, A.1    Tuszynski, M.H.2
  • 9
    • 4544293725 scopus 로고    scopus 로고
    • Rescue and sprouting of motoneurons following ventral root avulsion and reimplantation combined with intraspinal adeno-associated viral vector-mediated expression of glial cell line-derived neurotrophic factor or brain-derived neurotrophic factor
    • Blits B, Carlstedt TP, Ruitenberg MJ, et al. Rescue and sprouting of motoneurons following ventral root avulsion and reimplantation combined with intraspinal adeno-associated viral vector-mediated expression of glial cell line-derived neurotrophic factor or brain-derived neurotrophic factor. Exp Neurol 2004; 189: 303-316
    • (2004) Exp Neurol , vol.189 , pp. 303-316
    • Blits, B.1    Carlstedt, T.P.2    Ruitenberg, M.J.3
  • 10
    • 33645109586 scopus 로고    scopus 로고
    • Gene expression profiling reveals that peripheral nerve regeneration is a consequence of both novel injury-dependent and reactivated developmental processes
    • Bosse F, Hasenpusch-Theil K, Kury P, et al. Gene expression profiling reveals that peripheral nerve regeneration is a consequence of both novel injury-dependent and reactivated developmental processes. J Neurochem 2006; 96: 1441-1457
    • (2006) J Neurochem , vol.96 , pp. 1441-1457
    • Bosse, F.1    Hasenpusch-Theil, K.2    Kury, P.3
  • 11
    • 0036460111 scopus 로고    scopus 로고
    • A dose-dependent facilitation and inhibition of peripheral nerve regeneration by brain-derived neurotrophic factor
    • Boyd JG, Gordon T. A dose-dependent facilitation and inhibition of peripheral nerve regeneration by brain-derived neurotrophic factor. Eur J Neurosci 2002; 15: 613-626
    • (2002) Eur J Neurosci , vol.15 , pp. 613-626
    • Boyd, J.G.1    Gordon, T.2
  • 12
    • 0141448981 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor sustain the axonal regeneration of chronically axotomized motoneurons in vivo
    • Boyd JG, Gordon T. Glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor sustain the axonal regeneration of chronically axotomized motoneurons in vivo. Exp Neurol 2003; 183: 610-619
    • (2003) Exp Neurol , vol.183 , pp. 610-619
    • Boyd, J.G.1    Gordon, T.2
  • 13
    • 0042786843 scopus 로고    scopus 로고
    • Neurotrophic factors and their receptors in axonal regeneration and functional recovery after peripheral nerve injury
    • Boyd JG, Gordon T. Neurotrophic factors and their receptors in axonal regeneration and functional recovery after peripheral nerve injury. Mol Neurobiol 2003; 27: 277-324
    • (2003) Mol Neurobiol , vol.27 , pp. 277-324
    • Boyd, J.G.1    Gordon, T.2
  • 14
    • 43449120386 scopus 로고    scopus 로고
    • Misdirection of regenerating motor axons after nerve injury and repair in the rat sciatic nerve model
    • de Ruiter GC, Malessy MJ, Alaid AO, et al. Misdirection of regenerating motor axons after nerve injury and repair in the rat sciatic nerve model. Exp Neurol 2008; 211: 339-350
    • (2008) Exp Neurol , vol.211 , pp. 339-350
    • de Ruiter, G.C.1    Malessy, M.J.2    Alaid, A.O.3
  • 15
    • 0031799466 scopus 로고    scopus 로고
    • Adenoviral vector-mediated gene delivery to injured rat peripheral nerve
    • Dijkhuizen PA, Pasterkamp RJ, Hermens WT, et al. Adenoviral vector-mediated gene delivery to injured rat peripheral nerve. J Neurotrauma 1998; 15: 387-397
    • (1998) J Neurotrauma , vol.15 , pp. 387-397
    • Dijkhuizen, P.A.1    Pasterkamp, R.J.2    Hermens, W.T.3
  • 16
    • 0007101117 scopus 로고    scopus 로고
    • Pharmacokinetics of intrathecally applied BDNF and effects on spinal motoneurons
    • Dittrich F, Ochs G, Grosse-Wilde A, et al. Pharmacokinetics of intrathecally applied BDNF and effects on spinal motoneurons. Exp Neurol 1996; 141: 225-239
    • (1996) Exp Neurol , vol.141 , pp. 225-239
    • Dittrich, F.1    Ochs, G.2    Grosse-Wilde, A.3
  • 17
    • 0005868926 scopus 로고    scopus 로고
    • Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease
    • Eriksdotter Jonhagen M, Nordberg A, Amberla K, et al. Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease. Dement Geriatr Cogn Disord 1998; 9: 246-257
    • (1998) Dement Geriatr Cogn Disord , vol.9 , pp. 246-257
    • Eriksdotter Jonhagen, M.1    Nordberg, A.2    Amberla, K.3
  • 18
    • 0025225452 scopus 로고
    • An efficient deletion mutant packaging system for defective herpes simplex virus vectors: Potential applications to human gene therapy and neuronal physiology
    • Geller AI, Keyomarsi K, Bryan J, et al. An efficient deletion mutant packaging system for defective herpes simplex virus vectors: Potential applications to human gene therapy and neuronal physiology. Proc Natl Acad Sci USA 1990; 87: 8950-8954
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 8950-8954
    • Geller, A.I.1    Keyomarsi, K.2    Bryan, J.3
  • 19
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • Gossen M, Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA 1992; 89: 5547-5551
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 20
    • 0034008512 scopus 로고    scopus 로고
    • Sciatic nerve transection in the adult rat: Abnormal EMG patterns during locomotion by aberrant innervation of hindleg muscles
    • Gramsbergen A, Ijkema-Paassen J, Meek MF. Sciatic nerve transection in the adult rat: Abnormal EMG patterns during locomotion by aberrant innervation of hindleg muscles. Exp Neurol 2000; 161: 183-193
    • (2000) Exp Neurol , vol.161 , pp. 183-193
    • Gramsbergen, A.1    Ijkema-Paassen, J.2    Meek, M.F.3
  • 21
    • 23244461459 scopus 로고    scopus 로고
    • Effect of genetically modified Schwann cells with increased motility in end-to-side nerve grafting
    • Gravvanis AI, Lavdas A, Papalois AE, et al. Effect of genetically modified Schwann cells with increased motility in end-to-side nerve grafting. Microsurgery 2005; 25: 423-432
    • (2005) Microsurgery , vol.25 , pp. 423-432
    • Gravvanis, A.I.1    Lavdas, A.2    Papalois, A.E.3
  • 22
    • 29144480242 scopus 로고    scopus 로고
    • Differentially promoted peripheral nerve regeneration by grafted Schwann cells overexpressing different FGF-2 isoforms
    • Haastert K, Lipokatic E, Fischer M, et al. Differentially promoted peripheral nerve regeneration by grafted Schwann cells overexpressing different FGF-2 isoforms. Neurobiol Dis 2006; 21: 138-153
    • (2006) Neurobiol Dis , vol.21 , pp. 138-153
    • Haastert, K.1    Lipokatic, E.2    Fischer, M.3
  • 23
    • 42149170000 scopus 로고    scopus 로고
    • Lentiviral vector-mediated reporter gene expression in avulsed spinal ventral root is short-term, but is prolonged using an immune "stealth" transgene
    • Hendriks WT, Eggers R, Carlstedt TP, et al. Lentiviral vector-mediated reporter gene expression in avulsed spinal ventral root is short-term, but is prolonged using an immune "stealth" transgene. Restor Neurol Neurosci 2007; 25: 585-599
    • (2007) Restor Neurol Neurosci , vol.25 , pp. 585-599
    • Hendriks, W.T.1    Eggers, R.2    Carlstedt, T.P.3
  • 24
    • 0346219196 scopus 로고    scopus 로고
    • Viral vector-mediated gene transfer of neurotrophins to promote regeneration of the injured spinal cord
    • Hendriks WT, Ruitenberg MJ, Blits B, et al. Viral vector-mediated gene transfer of neurotrophins to promote regeneration of the injured spinal cord. Prog Brain Res 2004; 146: 451-476
    • (2004) Prog Brain Res , vol.146 , pp. 451-476
    • Hendriks, W.T.1    Ruitenberg, M.J.2    Blits, B.3
  • 25
    • 0024363535 scopus 로고
    • Herpes simplex virus latent RNA (LAT) is not required for latent infection in the mouse
    • Ho DY, Mocarski ES. Herpes simplex virus latent RNA (LAT) is not required for latent infection in the mouse. Proc Natl Acad Sci USA 1989; 86: 7596-7600
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 7596-7600
    • Ho, D.Y.1    Mocarski, E.S.2
  • 26
    • 33746520700 scopus 로고    scopus 로고
    • Mechanisms of disease: What factors limit the success of peripheral nerve regeneration in humans?
    • Hoke A. Mechanisms of disease: What factors limit the success of peripheral nerve regeneration in humans? Nat Clin Pract Neurol 2006; 2: 448-454
    • (2006) Nat Clin Pract Neurol , vol.2 , pp. 448-454
    • Hoke, A.1
  • 27
    • 33748887029 scopus 로고    scopus 로고
    • Schwann cells express motor and sensory phenotypes that regulate axon regeneration
    • Hoke A, Redett R, Hameed H, et al. Schwann cells express motor and sensory phenotypes that regulate axon regeneration. J Neurosci 2006; 26: 9646-9655
    • (2006) J Neurosci , vol.26 , pp. 9646-9655
    • Hoke, A.1    Redett, R.2    Hameed, H.3
  • 29
    • 14944359702 scopus 로고    scopus 로고
    • Proteomics of the injured rat sciatic nerve reveals protein expression dynamics during regeneration
    • Jimenez CR, Stam FJ, Li KW, et al. Proteomics of the injured rat sciatic nerve reveals protein expression dynamics during regeneration. Mol Cell Proteomics 2005; 4: 120-132
    • (2005) Mol Cell Proteomics , vol.4 , pp. 120-132
    • Jimenez, C.R.1    Stam, F.J.2    Li, K.W.3
  • 30
    • 0038392879 scopus 로고    scopus 로고
    • Repair of peripheral nerve transections with fibrin sealant containing neurotrophic factors
    • Jubran M, Widenfalk J. Repair of peripheral nerve transections with fibrin sealant containing neurotrophic factors. Exp Neurol 2003; 181: 204-212
    • (2003) Exp Neurol , vol.181 , pp. 204-212
    • Jubran, M.1    Widenfalk, J.2
  • 31
    • 34250683023 scopus 로고    scopus 로고
    • Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: An open label, phase I trial
    • Kaplitt MG, Feigin A, Tang C, et al. Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: An open label, phase I trial. Lancet 2007; 369: 2097-2105
    • (2007) Lancet , vol.369 , pp. 2097-2105
    • Kaplitt, M.G.1    Feigin, A.2    Tang, C.3
  • 32
    • 0042528664 scopus 로고    scopus 로고
    • Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model
    • Kaspar BK, Llado J, Sherkat N, et al. Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science 2003; 301: 839-842
    • (2003) Science , vol.301 , pp. 839-842
    • Kaspar, B.K.1    Llado, J.2    Sherkat, N.3
  • 33
    • 34447524954 scopus 로고    scopus 로고
    • A novel method for establishing daily in vivo concentration gradients of soluble nerve growth factor (NGF)
    • Kemp SW, Walsh SK, Zochodne DW, et al. A novel method for establishing daily in vivo concentration gradients of soluble nerve growth factor (NGF). J Neurosci Methods 2007; 165: 83-88
    • (2007) J Neurosci Methods , vol.165 , pp. 83-88
    • Kemp, S.W.1    Walsh, S.K.2    Zochodne, D.W.3
  • 34
    • 33645296022 scopus 로고    scopus 로고
    • Nerve conduit filled with GDNF gene-modified Schwann cells enhances regeneration of the peripheral nerve
    • Li Q, Ping P, Jiang H, et al. Nerve conduit filled with GDNF gene-modified Schwann cells enhances regeneration of the peripheral nerve. Microsurgery 2006; 26: 116-121
    • (2006) Microsurgery , vol.26 , pp. 116-121
    • Li, Q.1    Ping, P.2    Jiang, H.3
  • 35
    • 0034193047 scopus 로고    scopus 로고
    • A 25-year perspective of peripheral nerve surgery: Evolving neuroscientific concepts and clinical significance
    • Lundborg G. A 25-year perspective of peripheral nerve surgery: Evolving neuroscientific concepts and clinical significance. J Hand Surg [Am] 2000; 25: 391-414
    • (2000) J Hand Surg [Am] , vol.25 , pp. 391-414
    • Lundborg, G.1
  • 37
    • 0020582124 scopus 로고
    • Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus
    • Mann R, Mulligan RC, Baltimore D. Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus. Cell 1983; 33: 153-159
    • (1983) Cell , vol.33 , pp. 153-159
    • Mann, R.1    Mulligan, R.C.2    Baltimore, D.3
  • 38
    • 0034781791 scopus 로고    scopus 로고
    • Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery
    • Mazarakis ND, Azzouz M, Rohll JB, et al. Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery. Hum Mol Genet 2001; 10: 2109-2121
    • (2001) Hum Mol Genet , vol.10 , pp. 2109-2121
    • Mazarakis, N.D.1    Azzouz, M.2    Rohll, J.B.3
  • 39
    • 33645509696 scopus 로고    scopus 로고
    • Immobilized concentration gradients of neurotrophic factors guide neurite outgrowth of primary neurons in macroporous scaffolds
    • Moore K, MacSween M, Shoichet M. Immobilized concentration gradients of neurotrophic factors guide neurite outgrowth of primary neurons in macroporous scaffolds. Tissue Eng 2006; 12: 267-278
    • (2006) Tissue Eng , vol.12 , pp. 267-278
    • Moore, K.1    MacSween, M.2    Shoichet, M.3
  • 40
    • 33644850095 scopus 로고    scopus 로고
    • Adenoviral gene transfer of BDNF and GDNF synergistically prevent motoneuron loss in the nucleus ambiguus
    • Moro K, Shiotani A, Watabe K, et al. Adenoviral gene transfer of BDNF and GDNF synergistically prevent motoneuron loss in the nucleus ambiguus. Brain Res 2006; 1076: 1-8
    • (2006) Brain Res , vol.1076 , pp. 1-8
    • Moro, K.1    Shiotani, A.2    Watabe, K.3
  • 41
    • 0029996147 scopus 로고    scopus 로고
    • In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
    • Naldini L, Blomer U, Gallay P, et al. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 1996; 272: 263-267
    • (1996) Science , vol.272 , pp. 263-267
    • Naldini, L.1    Blomer, U.2    Gallay, P.3
  • 42
    • 0036727464 scopus 로고    scopus 로고
    • Pre-existing pathways promote precise projection patterns
    • Nguyen QT, Sanes JR, Lichtman JW. Pre-existing pathways promote precise projection patterns. Nat Neurosci 2002; 5: 861-867
    • (2002) Nat Neurosci , vol.5 , pp. 861-867
    • Nguyen, Q.T.1    Sanes, J.R.2    Lichtman, J.W.3
  • 43
    • 3242812919 scopus 로고    scopus 로고
    • Comparative analysis of genomic HSV vectors for gene delivery to motor neurons following peripheral inoculation in vivo
    • Perez MC, Hunt SP, Coffin RS, et al. Comparative analysis of genomic HSV vectors for gene delivery to motor neurons following peripheral inoculation in vivo. Gene Ther 2004; 11: 1023-1032
    • (2004) Gene Ther , vol.11 , pp. 1023-1032
    • Perez, M.C.1    Hunt, S.P.2    Coffin, R.S.3
  • 44
    • 33748375335 scopus 로고    scopus 로고
    • Neurotrophins: Mediators and modulators of pain
    • Pezet S, McMahon SB. Neurotrophins: Mediators and modulators of pain. Annu Rev Neurosci 2006; 29: 507-538
    • (2006) Annu Rev Neurosci , vol.29 , pp. 507-538
    • Pezet, S.1    McMahon, S.B.2
  • 45
    • 0037381513 scopus 로고    scopus 로고
    • Adenoviral gene transfer of GDNF, BDNF and TGF beta 2, but not CNTF, cardiotrophin-1 or IGF1, protects injured adult motoneurons after facial nerve avulsion
    • Sakamoto T, Kawazoe Y, Shen JS, et al. Adenoviral gene transfer of GDNF, BDNF and TGF beta 2, but not CNTF, cardiotrophin-1 or IGF1, protects injured adult motoneurons after facial nerve avulsion. J Neurosci Res 2003; 72: 54-64
    • (2003) J Neurosci Res , vol.72 , pp. 54-64
    • Sakamoto, T.1    Kawazoe, Y.2    Shen, J.S.3
  • 46
    • 57449101280 scopus 로고    scopus 로고
    • HSV amplicon vectors for gene delivery to the nervous system
    • Kaplitt MG, During MJ, eds, Boston, MA: Academic Press
    • Senn C, Fraefel C, Breakefield XO. HSV amplicon vectors for gene delivery to the nervous system. In: Kaplitt MG, During MJ, eds. Gene Therapy in the Central Nervous System, Boston, MA: Academic Press, 2006: pp. 25-38
    • (2006) Gene Therapy in the Central Nervous System , pp. 25-38
    • Senn, C.1    Fraefel, C.2    Breakefield, X.O.3
  • 47
    • 34347387360 scopus 로고    scopus 로고
    • Identification of candidate transcriptional modulators involved in successful regeneration after nerve injury
    • Stam FJ, MacGillavry HD, Armstrong NJ, et al. Identification of candidate transcriptional modulators involved in successful regeneration after nerve injury. Eur J Neurosci 2007; 25: 3629-3637
    • (2007) Eur J Neurosci , vol.25 , pp. 3629-3637
    • Stam, F.J.1    MacGillavry, H.D.2    Armstrong, N.J.3
  • 49
    • 37649016717 scopus 로고    scopus 로고
    • Genetic modification of human sural nerve segments by a lentiviral vector encoding nerve growth factor
    • Tannemaat MR, Boer GJ, Verhaagen J, et al. Genetic modification of human sural nerve segments by a lentiviral vector encoding nerve growth factor. Neurosurgery 2007; 61: 1286-1294
    • (2007) Neurosurgery , vol.61 , pp. 1286-1294
    • Tannemaat, M.R.1    Boer, G.J.2    Verhaagen, J.3
  • 50
    • 33748887028 scopus 로고    scopus 로고
    • Neurotrophin-3 gradients established by lentiviral gene delivery promote short-distance axonal bridging beyond cellular grafts in the injured spinal cord
    • Taylor L, Jones L, Tuszynski MH, et al. Neurotrophin-3 gradients established by lentiviral gene delivery promote short-distance axonal bridging beyond cellular grafts in the injured spinal cord. J Neurosci 2006; 26: 9713-9721
    • (2006) J Neurosci , vol.26 , pp. 9713-9721
    • Taylor, L.1    Jones, L.2    Tuszynski, M.H.3
  • 51
    • 0038363449 scopus 로고    scopus 로고
    • Axonal regeneration across long gaps in silicone chambers filled with Schwann cells overexpressing high molecular weight FGF-2
    • Timmer M, Robben S, Muller-Ostermeyer F, et al. Axonal regeneration across long gaps in silicone chambers filled with Schwann cells overexpressing high molecular weight FGF-2. Cell Transplant 2003; 12: 265-277
    • (2003) Cell Transplant , vol.12 , pp. 265-277
    • Timmer, M.1    Robben, S.2    Muller-Ostermeyer, F.3
  • 52
    • 0028060282 scopus 로고
    • Pharmacokinetics of nerve growth factor (NGF) following different routes of administration to adult rats
    • Tria MA, Fusco M, Vantini G, et al. Pharmacokinetics of nerve growth factor (NGF) following different routes of administration to adult rats. Exp Neurol 1994; 127: 178-183
    • (1994) Exp Neurol , vol.127 , pp. 178-183
    • Tria, M.A.1    Fusco, M.2    Vantini, G.3
  • 53
    • 21044458854 scopus 로고    scopus 로고
    • A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
    • Tuszynski MH, Thal L, Pay M, et al. A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease. Nat Med 2005; 11: 551-555
    • (2005) Nat Med , vol.11 , pp. 551-555
    • Tuszynski, M.H.1    Thal, L.2    Pay, M.3
  • 54
    • 31544478283 scopus 로고    scopus 로고
    • Adenoviral gene transfer in the peripheral nervous system
    • Watanabe TS, Ohtori S, Koda M, et al. Adenoviral gene transfer in the peripheral nervous system. J Orthop Sci 2006; 11: 64-69
    • (2006) J Orthop Sci , vol.11 , pp. 64-69
    • Watanabe, T.S.1    Ohtori, S.2    Koda, M.3
  • 55
    • 33746874152 scopus 로고    scopus 로고
    • Adeno-associated virus serotypes: Vector toolkit for human gene therapy
    • Wu Z, Asokan A, Samulski RJ. Adeno-associated virus serotypes: Vector toolkit for human gene therapy. Mol Ther 2006; 14: 316-327
    • (2006) Mol Ther , vol.14 , pp. 316-327
    • Wu, Z.1    Asokan, A.2    Samulski, R.J.3
  • 56
    • 0038618928 scopus 로고    scopus 로고
    • Efficiencies of transgene expression in nociceptive neurons through different routes of delivery of adeno-associated viral vectors
    • Xu Y, Gu Y, Wu P, et al. Efficiencies of transgene expression in nociceptive neurons through different routes of delivery of adeno-associated viral vectors. Hum Gene Ther 2003; 14: 897-906
    • (2003) Hum Gene Ther , vol.14 , pp. 897-906
    • Xu, Y.1    Gu, Y.2    Wu, P.3
  • 57
    • 0035114545 scopus 로고    scopus 로고
    • Neurotrophin-4 delivered by fibrin glue promotes peripheral nerve regeneration
    • Yin Q, Kemp GJ, Yu LG, et al. Neurotrophin-4 delivered by fibrin glue promotes peripheral nerve regeneration. Muscle Nerve 2001; 24: 345-351
    • (2001) Muscle Nerve , vol.24 , pp. 345-351
    • Yin, Q.1    Kemp, G.J.2    Yu, L.G.3
  • 58
    • 0035727935 scopus 로고    scopus 로고
    • Nerve growth factor and neurotrophin-3 affect functional recovery following peripheral nerve injury differently
    • Young C, Miller E, Nicklous DM, et al. Nerve growth factor and neurotrophin-3 affect functional recovery following peripheral nerve injury differently. Restor Neurol Neurosci 2001; 18: 167-175
    • (2001) Restor Neurol Neurosci , vol.18 , pp. 167-175
    • Young, C.1    Miller, E.2    Nicklous, D.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.