Life-threatening valproate overdose successfully treated with haemodialysis

Arhiv za Higijenu Rada i Toksikologiju

Volumn 59, Issue 4, 2008, Pages 295-298

  Meštrović, Julije ^a   Filipović, Tomislav ^a   Polić, Branka ^a   Stričević, Luka ^a   Omazić, Ante ^a   Kuzmanić Šamija, Radenka ^a   Markić, Joško ^a  

^a UNIVERSITY HOSPITAL SPLIT   (Croatia)

Author keywords

Central nervous system depressants; Intensive care; Thrombocytopenia; Toxicity

Indexed keywords

NALOXONE; VALPROIC ACID;

ADOLESCENT; ARTICLE; CASE REPORT; CLINICAL FEATURE; COMA; CONVALESCENCE; DRUG BLOOD LEVEL; DRUG OVERDOSE; DRUG TREATMENT FAILURE; FEMALE; HEMODIALYSIS; HUMAN; SUICIDE ATTEMPT;

ADOLESCENT; FEMALE; HUMANS; OVERDOSE; RENAL DIALYSIS; SUICIDE, ATTEMPTED; VALPROIC ACID;

EID: 57449086160     PISSN: 00041254     EISSN: None     Source Type: Journal    
DOI: 10.2478/10004-1254-59-2008-1884     Document Type: Article

References (10)

1. Spiller HA, Krenzelok EP, Klein-Schwartz W. Multicenter case series of valproic acid ingestion: serum concentrations and toxicity. J Toxicol Clin Toxicol 2000;38:755-60.
2. Roberge RJ, Francis EH 3rd. Use of naloxone in valproic acid overdose: case report and review. J Emerg Med 2002;22:67-70.
3. Dharnidharka VR, Fennell RS 3rd, Richard GA. Extracorporeal removal of toxic valproic acid levels in children. Pediatr Nephrol 2002;17:312-5.
4. Singh SM, McCormick BB, Mustata S, Thompson M, Prasad GV. Extracorporeal management of valproic acid overdose: A large regional experience. J Nephrol 2004;17:43-9.
5. Seger DL. Anticonvulsants. In: Haddad LM, Shannon MW, Winchester JF, editors. Clinical management of poisoning and drug overdose. 3rd edition. Philadelphia: WB Saunders; 1998. p. 655-63.
6. Acharya S, Bussel JB. Hematologic toxicity of sodium valproate. J Pediatr Hematol Oncol 2000;22:62-5.
7. Robinson P, Abbott C. Severe hypothermia in association with sodium valproate overdose. NZ Med J 2005;118:U1681.
8. Unal E, Kaya U, Aydin K. Fatal valproate overdose in a newborn baby. Hum Exp Toxicol 2007;26:453-6.
9. Hyden H, Cupello A, Palm A. Naloxone reverses the inhibition by sodium valproate of GABA transport across Deiters neuronal plasma membrane [letter]. Ann Neurol 1987;21:416-7.
10. Ingels M, Beauchamp J, Clark RF, Williams SR. Delayed valproic acid toxicity: a retrospective case series. Ann Emerg Med 2002;39:616-21.