The spectrum of 5-fluorouracil cardiotoxicity

Anti-Cancer Drugs

Volumn 20, Issue 1, 2009, Pages 79-80

  Dalzell, Jonathan R ^a   Samuel, Leslie M ^b  

^a WESTERN INFIRMARY   (United Kingdom)

^b ABERDEEN ROYAL INFIRMARY   (United Kingdom)

Author keywords

Cardiomyopathy; Cardiotoxicity; Chemotherapy; Fluorouracil; Ischaemia

Indexed keywords

AMIODARONE; FLUOROURACIL; FOLINIC ACID; METOPROLOL; OXALIPLATIN; RALTITREXED; RAMIPRIL;

ADULT; ARTICLE; CARDIOTOXICITY; CASE REPORT; COLON ADENOCARCINOMA; CONGESTIVE CARDIOMYOPATHY; HEART VENTRICLE FIBRILLATION; HUMAN; LIVER METASTASIS; MALE; MYOCARDITIS; PRIORITY JOURNAL;

ADENOCARCINOMA; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ARRHYTHMIAS, CARDIAC; CARDIOMYOPATHY, DILATED; CARDIOVASCULAR AGENTS; COLONIC NEOPLASMS; CORONARY VASOSPASM; FLUOROURACIL; HEART DISEASES; HUMANS; LEUCOVORIN; LIVER NEOPLASMS; MALE; MIDDLE AGED; MYOCARDITIS; ORGANOPLATINUM COMPOUNDS; TREATMENT OUTCOME; VENTRICULAR DYSFUNCTION, LEFT;

EID: 57349189383     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/CAD.0b013e3283165f27     Document Type: Article

References (14)

1. Dent RG, McColl I. 5-fluorouracil and angina. Lancet 1975; 1:347-348.
2. Keefe DL, Roistacher N, Pierri MK. Clinical cardiotoxicity of 5-fluorouracil. J Clin Pharmacol 1993; 33:1060-1070.
3. Misset B, Escudier B, Leclercq B, Rivara D, Rougier P, Nitenberg G. Acute myocardiotoxicity during 5-fluorouracil therapy. Intensive Care Med 1990; 16:210-211.
4. Coronel B, Madonna O, Mercatello A, Caillette A, Moskovtchenko JF. Myocardiotoxicity of 5 fluorouracil. Intensive Care Med 1988; 14:429-430.
5. Wang WS, Hsieh RK, Chiou TJ, Liu JH, Fan FS, Yen CC, et al. Toxic cardiogenic shock in a patient receiving weekly 24-h infusion of high-dose 5-fluorouracil and leucovorin. Jpn J Clin Oncol 1998; 28:551-554.
6. David JS, Gueugniaud PY, Hepp A, Gaussorgues P, Petit P. Severe heart failure secondary to 5-fluorouracil and low-doses of folinic acid: usefulness of an intra-aortic balloon pump. Crit Care Med 2000; 28:3558-3560.
7. Martin M, Diaz-Rubio E, Furió V, Blázquez J, Almenarez J, Fariña J. Lethal cardiac toxicity after cisplatin and 5-fluorouracil chemotherapy. Report of a case with necropsy study. Am J Clin Oncol 1989; 12:229-234.
8. Kuropkat C, Griem K, Clark J, Rodriguez ER, Hutchinson J, Taylor SG 4th. Severe cardiotoxicity during 5-fluorouracil chemotherapy: a case and literature report. Am J Clin Oncol 1999; 22:466-470.
9. Köhne CH, Thuss-Patience P, Friedrich M, Daniel PT, Kretzschmar A, Benter T, et al. Raltitrexed (Tomudex): an alternative drug for patients with colorectal cancer and 5-fluorouracil associated cardiotoxicity. Br J Cancer 1998; 77:973-977.
10. Mosseri M, Fingert HJ, Varticovski L, Chokshi S, Isner JM. In vitro evidence that myocardial ischemia resulting from 5-fluorouracil chemotherapy is due to protein kinase C-mediated vasoconstriction of vascular smooth muscle. Cancer Res 1993; 53:3028-3033.
11. Südhoff T, Enderle MD, Pahlke M, Petz C, Teschendorf C, Graeven U, et al. 5-fluorouracil induces arterial vasocontractions. Ann Oncol 2004; 15:661-664.
12. Luwaert RJ, Descamps O, Majois F, Chaudron JM, Beauduin M. Coronary artery spasm induced by 5-fluorouracil. Eur Heart J 1991; 12:468-470.
13. Shoemaker LK, Arora U, Rocha Lima CM. 5-fluorouracil-induced coronary vasospasm. Cancer Control 2004; 11:46-49.
14. Tsibiribi P, Bui-Xuan C, Bui-Xuan B, Lombard-Bohas C, Duperret S, Belkhiria M, et al. Cardiac lesions induced by 5-fluorouracil in the rabbit. Hum Exp Toxicol 2006; 25:305-309.