Cdc25A serine 123 phosphorylation couples centrosome duplication with DNA replication and regulates tumorigenesis

Molecular and Cellular Biology

Volumn 28, Issue 24, 2008, Pages 7442-7450

  Shreeram, Sathyavageeswaran ^a   Weng, Kee Hee ^a   Bulavin, Dmitry V ^a  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CELL DIVISION CYCLE PROTEIN 25A; PROTEIN TYROSINE PHOSPHATASE; SERINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL CYCLE PROGRESSION; CELL EXPANSION; CENTROSOME; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; GENE DUPLICATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

AMINO ACID SEQUENCE; ANIMALS; CDC25 PHOSPHATASES; CELL CYCLE; CENTROSOME; DNA DAMAGE; DNA REPLICATION; GENE KNOCK-IN TECHNIQUES; GENOTYPE; HUMANS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; NEOPLASMS; PHOSPHORYLATION; RADIATION, IONIZING; SERINE; SURVIVAL RATE;

ANIMALIA; MUS;

EID: 57349164068     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.00138-08     Document Type: Article

References (30)

1. Aleem, E., H. Kiyokawa, and P. Kaldis. 2005. Cdc2-cyclin E complexes regulate the G1/S phase transition. Nat. Cell Biol. 7:831-836.
2. Basto, R., K. Brunk, T. Vinadogrova, N. Peel, A. Franz, A. Khodjakov, and J. W. Raff. 2008. Centrosome amplification can initiate tumorigenesis in flies. Cell 133:1032-1042.
3. Bernardi, R., D. A. Liebermann, and B. Hoffman. 2000. Cdc25A stability is controlled by the ubiquitin-proteasome pathway during cell cycle progression and terminal differentiation. Oncogene 19:2447-2454.
4. Blomberg, I., and I. Hoffmann. 1999. Ectopic expression of Cdc25A accelerates the G1/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinases. Mol. Cell. Biol. 19:6183-6194.
5. Chen, M. S., C. E. Ryan, and H. Piwnica-Worms. 2003. Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding. Mol. Cell. Biol. 23:7488-7497.
6. Conklin, D. S., K. Galaktionov, and D. Beach. 1995. 14-3-3 proteins associate with cdc25 phosphatases. Proc. Natl. Acad. Sci. USA 92:7892-7896.
7. Doxsey, S. 2002. Duplicating dangerously: linking centrosome duplication and aneuploidy. Mol. Cell 10:439-440.
8. Falck, J., N. Mailand, R. G. Syljuasen, J. Bartek, and J. Lukas. 2001. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 410:842-847.
9. Gabrielli, B. G., C. P. De Souza, I. D. Tonks, J. M. Clark, N. K. Hayward, and K. A. Ellem. 1996. Cytoplasmic accumulation of cdc25B phosphatase in mitosis triggers centrosomal microtubule nucleation in HeLa cells. J. Cell Sci. 109:1081-1093.
10. Galaktionov, K., and D. Beach. 1991. Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. Cell 67:1181-1194.
11. Galaktionov, K., X. Chen, and D. Beach. 1996. Cdc25 cell-cycle phosphatase as a target of c-myc. Nature 382:511-517.
12. Galaktionov, K., A. K. Lee, J. Eckstein, G. Draetta, J. Meckler, M. Loda, and D. Beach. 1995. CDC25 phosphatases as potential human oncogenes. Science 269:1575-1577.
13. Gasparotto, D., R. Maestro, S. Piccinin, T. Vukosavljevic, L. Barzan, S. Sulfaro, and M. Boiocchi. 1997. Overexpression of CDC25A and CDC25B in head and neck cancers. Cancer Res. 57:2366-2368.
14. Goloudina, A., H. Yamaguchi, D. B. Chervyakova, E. Appella, A. J. Fornace, Jr., and D. V. Bulavin. 2003. Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint. Cell Cycle 2:473-478.
15. Hassepass, I., R. Voit, and I. Hoffmann. 2003. Phosphorylation at serine 75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint. J. Biol. Chem. 278:29824-29829.
16. Heffernan, T. P., K. Unsal-Kaçmaz, A. N. Heinloth, D. A. Simpson, R. S. Paules, A. Sancar, M. Cordeiro-Stone, and W. K. Kaufmann. 2007. Cdc7-Dbf4 and the human S checkpoint response to UVC. J. Biol. Chem. 282:9458-9468.
17. Hinchcliffe, E. H., C. Li, E. A. Thompson, J. L. Maller, and G. Sluder. 1999. Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts. Science 283:851-854.
18. Hoffmann, I., G. Draetta, and E. Karsenti. 1994. Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transition. EMBO J. 13:4302-4310.
19. Jinno, S., K. Suto, A. Nagata, M. Igarashi, Y. Kanaoka, H. Nojima, and H. Okayama. 1994. Cdc25A is a novel phosphatase functioning early in the cell cycle. EMBO J. 13:1549-1556.
20. Lacey, K. R., P. K. Jackson, and T. Stearns. 1999. Cyclin-dependent kinase control of centrosome duplication. Proc. Natl. Acad. Sci. USA 96:2817-2822.
21. Lammer, C., S. Wagerer, R. Saffrich, D. Mertens, W. Ansorge, and I. Hoffmann. 1998. The cdc25B phosphatase is essential for the G2/M phase transition in human cells. J. Cell Sci. 111:2445-2453.
22. Mailand, N., J. Falck, C. Lukas, R. G. Syljuasen, M. Welcker, J. Bartek, and J. Lukas. 2000. Rapid destruction of human Cdc25A in response to DNA damage. Science 288:1425-1429.
23. Meraldi, P., J. Lukas, A. M. Fry, J. Bartek, and E. A. Nigg. 1999. Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A. Nat. Cell Biol. 1:88-93.
24. Molinari, M., C. Mercurio, J. Dominguez, F. Goubin, and G. F. Draetta. 2000. Human Cdc25A inactivation in response to S phase inhibition and its role in preventing premature mitosis. EMBO Rep. 1:71-79.
25. Sadhu, K., S. I. Reed, H. Richardson, and P. Russell. 1990. Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2. Proc. Natl. Acad. Sci. USA 87:5139-5143.
26. CIP1 and Cdc25A: competition between an inhibitor and an activator of cyclin-dependent kinases. Mol. Cell. Biol. 17:4338-4345.
27. Sluder, G., and J. J. Nordberg. 2004. The good, the bad and the ugly: the practical consequences of centrosome amplification. Curr. Opin. Cell Biol. 16:49-54.
28. Vigo, E., H. Muller, E. Prosperini, G. Hateboer, P. Cartwright, M. C. Moroni, and K. Helin. 1999. CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase. Mol. Cell. Biol. 19:6379-6395.
29. Xu, X., and S. P. Burke. 1996. Roles of active site residues and the NH2-terminal domain in the catalysis and substrate binding of human Cdc25. J. Biol. Chem. 271:5118-5124.
30. Zhao, H., J. L. Watkins, and H. Piwnica-Worms. 2002. Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints. Proc. Natl. Acad. Sci. USA 99:14795-14800.