Comparative analysis of temozolomide (TMZ) versus 1,3-bis (2-chloroethyl)-1 nitrosourea (BCNU) in newly diagnosed glioblastoma multiforme (GBM) patients

Journal of Neuro-Oncology

Volumn 91, Issue 2, 2009, Pages 221-225

  Vinjamuri, Mridula ^a   Adumala, Rakesh R ^a   Altaha, Ramin ^a   Hobbs, Gerald R ^a   Crowell Jr , Edward B ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

1,3 Bis(2 chloroethyl) 1 nitrosourea; Adjuvant chemotherapy; BCNU; Bevacizumab; Glioblastoma multiforme; Malignant glioma; Prognostic factors; Salvage therapy; Temozolomide

Indexed keywords

BEVACIZUMAB; CARMUSTINE; CISPLATIN; ETOPOSIDE; IRINOTECAN; PROCARBAZINE; TAMOXIFEN; TEMOZOLOMIDE; THALIDOMIDE;

ADULT; ARTICLE; BRAIN BIOPSY; BRAIN SURGERY; CANCER ADJUVANT THERAPY; CANCER CHEMOTHERAPY; CANCER CONTROL; CANCER RADIOTHERAPY; CANCER SURVIVAL; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG RESPONSE; DRUG TOLERABILITY; DRUG WITHDRAWAL; FATIGUE; FEMALE; GLIOBLASTOMA; HUMAN; LETHARGY; LOG RANK TEST; LUNG DIFFUSION CAPACITY; LUNG DISEASE; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; OVERALL SURVIVAL; PROGNOSIS; RETROSPECTIVE STUDY; SALVAGE THERAPY; SIDE EFFECT; SURVIVAL TIME; THROMBOCYTOPENIA;

ANTINEOPLASTIC AGENTS, ALKYLATING; CARMUSTINE; CENTRAL NERVOUS SYSTEM NEOPLASMS; COMBINED MODALITY THERAPY; DACARBAZINE; DISEASE-FREE SURVIVAL; FEMALE; GLIOBLASTOMA; HUMANS; MALE; MIDDLE AGED; NEOPLASM STAGING; RADIOTHERAPY; RETROSPECTIVE STUDIES; SALVAGE THERAPY; TREATMENT OUTCOME;

EID: 57349148269     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-008-9702-6     Document Type: Article

References (14)

1. Stewart LA (2002) Chemotherapy in adult high-grade glioma: A systematic review and meta-analysis of individual patient data from 12 randomized trials. Lancet 359:1011-1018. doi: 10.1016/S0140-6736(02)08091-1
2. Hauch H, Sajedi M, Wolff JE (2005) Treatment arms summarizing analysis of 220 high-grade glioma studies. Anticancer Res 25:3585-3590
3. Nelson DF, Diener-West M, Horton J, Chang CH, Schoenfeld D, Nelson JS (1988) Combined modality approach to treatment of malignant gliomas-re-evaluation of RTOG 7401/ECOG 1374 with long-term follow-up: A joint study of the Radiation Therapy Oncology Group and the Eastern Cooperative Oncology Group. NCI Monogr 6:279-284
4. Fine HA, Dear KB, Loeffler JS, Black PM, Canellos GP (1993) Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adult. Cancer 71:2585-2597. doi:10.1002/ 1097-0142(19930415)71:8<2585::AID-CNCR2820710825>3.0.CO;2-S
5. Stenning SP, Freedman LS, Bleehen NM (1987) Overview of published results from randomized studies of nitrosoureas in primary high grade malignant glioma. Br J Cancer 56:89-90
6. Solero CL, Monfardini S, Brambilla C, Vaghi A, Valagussa P, Morello G et al (1979) Controlled study with BCNU vs. CCNU as adjuvant chemotherapy following surgery plus radiotherapy for glioblastoma multiforme. Cancer Clin Trials 2:43-48
7. Nelson DF, Schoenfeld D, Weinstein AS, Nelson JS, Wasserman T, Goodman RL et al (1983) A randomized comparison of misonidazole sensitized radiotherapy plus BCNU and radiotherapy plus BCNU for treatment of malignant glioma after surgery; preliminary results of an RTOG study. Int J Radiat Oncol Biol Phys 9:1143-1151
8. Stupp R, Ostermann Kraljevic S, Dietrich P, Pica A, Maillard I, Maeder M, Miralbell R, Collao C, Villemure J, de Tribolet N, Mirimanoff R, Leyvraz S (2000) Promising survival with concomitant and adjuvant temozolomide for newly diagnosed glioblastoma multiforme. Proc Am Soc Clin Oncol 19:163 (abstr 632)
9. Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJB, European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups and the National Cancer Institute of Canada Clinical Trials Group et al (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352:987-996. doi: 10.1056/NEJMoa043330
10. Stupp R, Hegi ME, Gilbert MR, Chakravarti A (2007) Chemoradiotherapy in malignant glioma: Standard of care and future directions. J Clin Oncol 25:4127-4136. doi: 10.1200/JCO.2007.11.8554
11. Grossman SA, O'Neill A, Grunnet M, Mehta M, Pearlman JL, Wagner H, Eastern Cooperative Oncology Group et al (2003) Phase III study comparing three cycles of infusional carmustine and cisplatin followed by radiation therapy with radiation therapy and concurrent carmustine in patients with newly diagnosed supratentorial glioblastoma multiforme: Eastern Cooperative Oncology Group Trial 2394. J Clin Oncol 21:1485-1491. doi: 10.1200/JCO.2003.10.035
12. Levin VA, Wara WM, Davis RL, Vestnys P, Resser KJ, Yatsko K et al (1985) Phase III comparison of BCNU and the combination of procarbazine, CCNU, and vincristine administered after radiotherapy with hydroxyurea for malignant gliomas. J Neurosurg 63:218-223
13. Jeremic B, Milicic B, Grujicic D, Dagovic A, Aleksandrovic J (2003) Multivariate analysis of clinical prognostic factors in patients with glioblastoma multiforme treated with a combined modality approach. J Cancer Res Clin Oncol 129:477-484. doi: 10.1007/s00432-003-0471-5
14. Vredenburgh JJ, Desjardins A, Herndon JEII, Marcello J, Reardon DA, Quinn JA et al (2007) Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. J Clin Oncol 25:4722-4729. doi: 10.1200/ JCO.2007.12.2440