Quantitative analysis of NK1 receptor in the human brain using PET with18F-FE-SPA-RQ

Journal of Nuclear Medicine

Volumn 49, Issue 11, 2008, Pages 1749-1755

  Okumura, Masaki ^a,b   Arakawa, Ryosuke ^a,b   Ito, Hiroshi ^a   Seki, Chie ^a   Takahashi, Hidehiko ^a   Takano, Harumasa ^a   Haneda, Eisuke ^a,b   Nakao, Ryuji ^a   Suzuki, Hidenori ^b   Suzuki, Kazutoshi ^a   Okubo, Yoshiro ^b   Suhara, Tetsuya ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

18F FE SPA RQ; Human brain; NK1 receptor; PET; Substance P

Indexed keywords

FLUOROETHYL [2 FLUOROMETHOXY 5 (5 TRIFLUOROMETHYLTETRAZOL 1 YL)BENZYL] (2 PHENYLPIPERIDIN 3 YLAMINE) F 18; NEUROKININ 1 RECEPTOR; RADIOLIGAND; UNCLASSIFIED DRUG; (2 FLUOROMETHOXY 5 (5 TRIFLUOROMETHYLTETRAZOL 1 YL)BENZYL)(2 PHENYLPIPERIDIN 3 YL)AMINE; (2-FLUOROMETHOXY-5-(5-TRIFLUOROMETHYLTETRAZOL-1-YL)BENZYL)(2-PHENYLPIPERIDIN-3-YL)AMINE; DIAGNOSTIC AGENT; PIPERIDINE DERIVATIVE; TETRAZOLE DERIVATIVE;

ADULT; ARTICLE; BINDING AFFINITY; BLOOD SAMPLING; BRAIN REGION; CONTROLLED STUDY; HUMAN; HUMAN EXPERIMENT; IMAGE ANALYSIS; MALE; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RADIOACTIVITY; ARTERY; BLOOD; BRAIN; CLINICAL TRIAL; METABOLISM; REPRODUCIBILITY; SCINTISCANNING; TIME;

ADULT; ARTERIES; BRAIN; HUMANS; MALE; PIPERIDINES; POSITRON-EMISSION TOMOGRAPHY; RECEPTORS, NEUROKININ-1; REPRODUCIBILITY OF RESULTS; TETRAZOLES; TIME FACTORS; YOUNG ADULT;

EID: 57349147311     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.108.054353     Document Type: Article

References (33)

1. Baker KG, Halliday GM, Hornung JP, Geffen LB, Cotton RG, Tork I. Distribution, morphology and number of monoamine-synthesizing and substance P-containing neurons in the human dorsal raphe nucleus. Neuroscience. 1991;42:757-775.
2. Nicholas AP, Pieribone VA, Arvidsson U, Hokfelt T. Serotonin-, substance P- and glutamate/aspartate-like immunoreactivities in medullo-spinal pathways of rat and primate. Neuroscience. 1992;48:545-559.
3. Sergeyev V, Hokfelt T, Hurd Y. Serotonin and substance P co-exist in dorsal raphe neurons of the human brain. Neuroreport. 1999;10:3967-3970.
4. Vincent SR, Satoh K, Armstrong DM, Panula P, Vale W, Fibiger HC. Neuropeptides and NADPH-diaphorase activity in the ascending cholinergic reticular system of the rat. Neuroscience. 1986;17:167-182.
5. Masu Y, Nakayama K, Tamaki H, Harada Y, Kuno M, Nakanishi S. cDNA cloning of bovine substance-K receptor through oocyte expression system. Nature. 1987;329:836-838.
6. Nakanishi S. Mammalian tachykinin receptors. Annu Rev Neurosci. 1991;14:123-136.
7. 3) in the central nervous system of the rat. J Comp Neurol. 1996;364:290-310.
8. Nakaya Y, Kaneko T, Shigemoto R, Nakanishi S, Mizuno N. Immunohistochemical localization of substance P receptor in the central nervous system of the adult rat. J Comp Neurol. 1994;347:249-274.
9. Snider WD, McMahon SB. Tackling pain at the source: new ideas about nociceptors. Neuron. 1998;20:629-632.
10. 3 receptors as targets for drugs to treat gastrointestinal motility disorders and pain. Br J Pharmacol. 2004;141:1303-1312.
11. Kincy-Cain T, Bost KL. Increased susceptibility of mice to Salmonella infection following in vivo treatment with the substance P antagonist, spantide II. J Immunol. 1996;157:255-264.
12. Metwali A, Blum AM, Elliott DE, Setiawan T, Weinstock JV. Cutting edge: hemokinin has substance P-like function and expression in inflammation. J Immunol. 2004;172:6528-6532.
13. Hesketh PJ, Van Belle S, Aapro M, et al. Differential involvement of neurotransmitters through the time course of cisplatin-induced emesis as revealed by therapy with specific receptor antagonists. Eur J Cancer. 2003;39:1074-1080.
14. Hesketh PJ, Grunberg SM, Gralla RJ, et al. The oral neurokinin-1 antagonist aprepitant for the prevention of chemotherapy-induced nausea and vomiting: a multinational, randomized, double-blind, placebo-controlled trial in patients receiving high-dose cisplatin - the Aprepitant Protocol 052 Study Group. J Clin Oncol. 2003;21:4112-4119.
15. de Wit R, Herrstedt J, Rapoport B, et al. Addition of the oral NK1 antagonist aprepitant to standard antiemetics provides protection against nausea and vomiting during multiple cycles of cisplatin-based chemotherapy. J Clin Oncol. 2003;21:4105-4111.
16. Kramer MS, Cutler N, Feighner J, et al. Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science. 1998;281:1640-1645.
17. 1) receptor antagonist in major depression. Neuropsychopharmacology. 2004;29:385-392.
18. Keller M, Montgomery S, Ball W, et al. Lack of efficacy of the substance p (neurokinin1 receptor) antagonist aprepitant in the treatment of major depressive disorder. Biol Psychiatry. 2006;59:216-223.
19. 18F]SPA-RQ). Mol Imaging Biol. 2004;6:373-384.
20. Bergstrom M, Hargreaves RJ, Burns HD, et al. Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant. Biol Psychiatry. 2004;55:1007-1012.
21. Hargreaves R. Imaging substance P receptors (NK1) in the living human brain using positron emission tomography. J Clin Psychiatry. 2002;63(suppl 11):S18-S24.
22. 1) receptors in the human brain. Mol Imaging Biol. 2005;7:262-272.
23. 1) receptor PET ligand [abstract]. J Labelled Comp Radiopharm. 2003;46(suppl 1):S35.
24. Haneda E, Higuchi M, Maeda J, et al. In vivo mapping of substance P receptors in brains of laboratory animals by high-resolution imaging systems. Synapse. 2007;61:205-215.
25. 18F]FEDAA1106: two positron-emitter labeled ligands for peripheral benzodiazepine receptor (PBR). Bioorg Med Chem Lett. 2003;13:201-204.
26. Ito H, Takahashi H, Arakawa R, Takano H, Suhara T. Normal database of dopaminergic neurotransmission system in human brain measured by positron emission tomography. Neuroimage. 2008;39:555-565.
27. Innis RB, Cunningham VJ, Delforge J, et al. Consensus nomenclature for in vivo imaging of reversibly binding radioligands. J Cereb Blood Flow Metab. 2007;27:1533-1539.
28. Caberlotto L, Hurd YL, Murdock P, et al. Neurokinin 1 receptor and relative abundance of the short and long isoforms in the human brain. Eur J Neurosci. 2003;17:1736-1746.
29. 2 dopamine receptors in the human brain. Neuroimage. 2001;13:531-539.
30. Lammertsma AA, Hume SP. Simplified reference tissue model for PET receptor studies. Neuroimage. 1996;4:153-158.
31. 1 receptor binding profile in gerbil and human brain. Br J Pharmacol. 2006;148:39-45.
32. Farde L, Ito H, Swahn CG, Pike VW, Halldin C. Quantitative analyses of carbonyl-carbon-11-WAY-100635 binding to central 5-hydroxytryptamine-1A receptors in man. J Nucl Med. 1998;39:1965-1971.
33. 11C-MADAM binding to the serotonin transporter in the human brain. J Nucl Med. 2005;46:1505-1515.