Structural characterization of novel adenine dinucleotide phosphate conjugates of imatinib in incubations with rat and human liver microsomes

Drug Metabolism and Disposition

Volumn 36, Issue 12, 2008, Pages 2414-2418

  Ma, Shuguang ^a,b   Subramanian, Raju ^a   Xu, Yang ^a   Schrag, Michael ^a,c   Shou, Magang ^a  

^a AMGEN INC   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c ARRAY BIOPHARMA INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; IMATINIB; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANIMAL TISSUE; ARTICLE; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; DRUG CONJUGATION; DRUG INDICATION; DRUG METABOLISM; DRUG STRUCTURE; GASTROINTESTINAL STROMAL TUMOR; HUMAN; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SCALE UP; TANDEM MASS SPECTROMETRY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICROSOMES, LIVER; MOLECULAR STRUCTURE; NAD+ NUCLEOSIDASE; NADP; PIPERAZINES; PROTEIN KINASE INHIBITORS; PYRIMIDINES; RATS;

RATTUS;

EID: 57349146643     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.023085     Document Type: Article

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