Upregulation of GLUT-4 in right ventricle of rats with monocrotaline- induced pulmonary hypertension

Medical Science Monitor

Volumn 14, Issue 12, 2008, Pages

  Broderick, Tom L ^a   King, Tiffany M ^a  

^a MIDWESTERN UNIVERSITY   (United States)

Author keywords

Cardiac; Glucose; GLUT4; Hypertrophy; Remodeling

Indexed keywords

GLUCOSE TRANSPORTER 4; MONOCROTALINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DISEASE COURSE; HEART LEFT VENTRICLE; HEART RIGHT VENTRICLE; HEART RIGHT VENTRICLE HYPERTROPHY; HEART VENTRICLE REMODELING; HEART WEIGHT; LIVER WEIGHT; LUNG WEIGHT; MALE; NONHUMAN; PROTEIN CONTENT; PULMONARY HYPERTENSION; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

ANIMALS; GLUCOSE TRANSPORTER TYPE 4; HEART VENTRICLES; HYPERTENSION, PULMONARY; MALE; MONOCROTALINE; RATS; RATS, SPRAGUE-DAWLEY; UP-REGULATION;

EID: 57349144502     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Yi ES, Kim H, Ahn H et al: Distribution of obstructive intimal lesions and their cellular phenotypes in chronic pulmonary hypertension: A morphometric and immunohistochemical study. Am J Respir Crit Care Med, 2000; 162: 1577-86
2. Strauss BH, Rabinovitch M: Adventitial fibroblasts: defining a role in vessel wall remodeling. Am J Respir Cell Mol Biol, 2000; 20: 1-3
3. D'Alonzo, GE, Barst RJ, Ayres SM et al: Survival in patients with primary pulmonary hypertension: results from a national prospective registry. Ann Intern Med, 1991; 115: 343-49
4. Rosenberg HC, Rabinovitch M: Endothelial injury and vascular reactivity in monocrotaline pulmonary hypertension. Am J Physiol, 1988; 255: H1484-91
5. Lamberts RR, Vaessen RK, Westerhof N, Stienen GJM: Right ventricular hypertrophy causes impairment of left ventricular diastolic function in the rat. Basic Res Cardiol, 2007; 102: 19-27
6. Werchan PM, Summer WR, Gerdes AM, McDonough KH: Right ventricular performance after monocrotaline-induced pulmonary hypertension. Am J Physiol, 1989; 256: H1328-36
7. Akhavein F, Jean St.-Michel E, Seifert E, Rohlicek CV: Decreased left ventricular function, myocarditis, and coronary arteriolar medial thickening following monocrotaline administration in adult rats. J Appl Physiol, 2007; 103: 287-95
8. Neubauer S: The failing heart-an engine out of fuel. N Eng J Med, 2007; 256: 1140-51
9. Osorio JC, Stanley WC, Linke A et al: Impaired myocardial fatty acid oxidation and reduced protein expression of retinoid x receptor-α in pacing-induced heart failure. Circulation, 2002; 106: 606-12
10. Razeghi P, Young ME, Alcorn JL et al: Metabolic gene expression in fetal and failing human heart. Circulation, 2001; 104: 2923-31
11. Taylor M, Wallhaus TR, Delgrado TR et al: An evaluation of myocardial fatty acid and glucose uptake using PET with [18F]fluoro-6-thia-heptadecanoic acid and [18F]FDG in patients with congestive heart failure J Nucl Med, 2001; 42: 55-62
12. Chandler MP, Kerner J, Huang H et al: Moderate severity heart failure does not involve a downregulation of myocardial fatty acid oxidation Am J Physiol Heart Circ Physiol, 2004; 287: H1538-43
13. Remondino A, Rosenblatt-Velin N, Montessuit C et al: Altered expression of proteins of metabolic regulation during remodeling of the left ventricle after myocardial infarction. Altered expression of proteins of metabolic regulation during remodeling of the left ventricle after myocardial infarction. J Mol Cell Cardiol, 2000; 32: 2025-34
14. Young LH, Renfu Y, Russell R et al: Low-flow ischemia leads to translocation of canine heart GLUT-4 and GLUT-1 glucose transporters to the sarcolemma in vivo. Circulation, 1997; 95: 415-22
15. Carter Ralphe J, Nau PN, Mascio CE et al: Regulation of myocardial glucose transporters GLUT1 and GLUT4 in chronically anemic fetal lambs. Ped Res, 2005; 58: 713-18
16. Osborn BA, Daar JT, Laddaga RA et al: Exercise training increases sarcolemmal GLUT-4 protein and mRNA content in diabetic heart. J Appl Physiol, 1997; 82: 828-34
17. Stanley WC, Recchia FA, Lopaschuk GD: Myocardial substrate metabolism in the normal and failing heart. Physiol Rev, 2005; 85: 1093-129
18. Oikawa M, Kagaya Y, Otani H et al: Increased [18F] fluorodeoxyglucose accumulation in right ventricular free wall in patients with pulmonary hypertension and the effect of epoprostenol. J Am Coll Cardiol, 2005; 45: 1849-55