Orthostatic hypotension induced by postural change in the rat (tilt test)

Current Protocols in Pharmacology

Volumn , Issue SUPPL. 40, 2008, Pages

  Guillaume, Philippe ^a   Hervé, Stéphane ^a   Picard, Sandra ^a   Lacroix, Pierre ^a  

^a Porsolt and Partners Pharmacology   (France)

Author keywords

Animal models; Arterial blood pressure; Cardiovascular effects; Orthostatic hypotension; Safety pharmacology

Indexed keywords

PRAZOSIN;

ARTERIAL PRESSURE; BLOOD PRESSURE MEASUREMENT; BODY POSTURE; CARDIOTOXICITY; DIASTOLIC BLOOD PRESSURE; EXPERIMENTAL RAT; HEAD TILTING; HEART RATE; NONHUMAN; ORTHOSTATIC HYPOTENSION; PRIORITY JOURNAL; REVIEW; SYSTOLIC BLOOD PRESSURE; TASK PERFORMANCE; TILT TABLE TEST;

ANESTHESIA; ANIMALS; BLOOD PRESSURE; DRUG EVALUATION, PRECLINICAL; DRUG TOXICITY; HEART RATE; HYPOTENSION, ORTHOSTATIC; MALE; POSTURE; RATS; RATS, WISTAR; TILT-TABLE TEST;

EID: 57349138355     PISSN: 19348282     EISSN: 19348290     Source Type: Journal    
DOI: 10.1002/0471141755.ph0545s40     Document Type: Review

References (14)

1. Akiyama, K., Hora, M., Yamagishi, R., and Kitazawa, M. 2002. Effects of KMD-3213, a uroselective α1A-adrenoceptor antagonist, on the tilt-induced blood pressure response in normotensive rats. Jpn. J. Pharmacol. 90:131-137.
2. Carruthers, S.G. 1994. Adverse effects of alpha 1-adrenergic blocking drugs. Drug Safety 11:12-20.
3. Dampney, R.A.L., Coleman, M.J., Fontes, M.A.P., Hirooka, Y., Horiuchi, J., Li, Y-W., Polson, J.W., Potts, P.D., and Tagawa, T. 2002. Central mechanisms underlying short- and long-term regulation of the cardiovascular system. Clin. Exp. Pharmacol. Physiol. 29:261-268.
4. Donovan, J.D. and Brown, P. 2006. Parenteral injections. Curr Protoc. Immunol. 73:1.6.1-1.6.10.
5. Golin, R.M., Gotoh, E., Said, S.I., and Ganong, W.F. 1988. Pharmacological evidence that the sympathetic nervous system mediates the increase in renin secretion produced by immobilization and head-up tilt in rats. Neuropharmacology 27:1209-1213.
6. Hashimoto, Y., Ohashi, R., Minami, K., and Narita, H. 1999. Comparative study of TA-606, a novel angiotensin II receptor antagonist, with losartan in terms of species difference and orthostatic hypotension. Jpn. J. Pharmacol. 81:63-72.
7. Matos de Moura, M., Sousa dos Santos, R.A., and Peliky Fontes, M.A. 2005. Evidence for a functional cardiac interaction between losartan and angiotensin-(1-7) receptors revealed by orthostatic tilting test in rats. Br. J. Pharmacol. 144:755-760.
8. McCall, R.B. and Humphrey, S.J. 1981. Evidence of a central depressor action of postsynaptic alpha 1-adrenergic receptor antagonists. J. Auton. Nerv. Syst. 3:9-23.
9. Ohlstein, E.H., Gellai, M., Brooks, D.P., Vickery, L., Jugus, J., Sulpizio, A., Ruffolo, R.R., Weinstock, J., and Edwards, R.M. 1992. The antihypertensive effect of the angiotensin II receptor antagonist DuP 753 may not be due solely to angiotensin II receptor antagonism. J. Pharmacol. Exp. Ther. 262:595-601.
10. Persson, B., Yao, T., and Thorén, P. 1981. Correlation between decreased heart rate and central inhibition of sympathetic discharge after prazosin administration in the spontaneous hypertensive rat. Clin. Exp. Hypertens. 3:245-255.
11. Schwartz, K.M., Urthaler, F., and James, T.N. 1982. The direct negative chronotropic action of prazosin on the canine sinus node. J. Pharmacol. Exp. Ther. 221:801-805.
12. Stella, A., Dampney, R.A., Golin, R., and Zanchetti, A. 1978. Differences in reflex control of arterial blood pressure and renin release during head-up tilting in the cat. Clin. Sci. Mol. Med. Suppl. 4:179S-181S.
13. Take, H., Shibata, K., Awaji, T., Hirasawa, A., Ikegaki, I., Asano, T., Takada, T., and Tsujimoto, G. 1998. Vascular α1-adrenoceptor subtype selectivity and α1-blocker-induced orthostatic hypotension. Jpn. J. Pharmacol. 77:61-70.
14. Tsunoo, M., Shishito, A., Yoshii, Y., Komori, M., and Shimoyama, M. 1990. Phase I clinical trial of YM617, a new α1 adrenoceptor antagonist - First report: A single oral dose of conventional formulation in healthy male subjects. Rinshoiyaku 12:2503-2528.