Comparison and validation of drug loading parameters of PEGylated nanoparticles purified by a diafiltration centrifugal device and tangential flow filtration

Drug Development and Industrial Pharmacy

Volumn 34, Issue 12, 2008, Pages 1331-1342

  Dalwadi, Gautam ^a   Sunderland, Bruce ^a  

^a CURTIN UNIVERSITY   (Australia)

Author keywords

Diafiltration centrifugal devices; Drug loading; Nanoparticles; PEGylation; Tangential flow filtration; Ultracentrifugation; Ultrafiltration

Indexed keywords

DEXTRAN SULFATE; LOPERAMIDE; NANOPARTICLE; POLYVINYL ALCOHOL;

ARTICLE; DIAFILTRATION; DRUG PURIFICATION; NANOENCAPSULATION; TANGENTIAL FLOW FILTRATION; ULTRAFILTRATION; VALIDATION PROCESS;

CHEMISTRY, PHARMACEUTICAL; ENKEPHALIN, LEUCINE-2-ALANINE; LOPERAMIDE; NANOPARTICLES; POLYETHYLENE GLYCOLS; ULTRACENTRIFUGATION; ULTRAFILTRATION;

EID: 57349135801     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.1080/03639040802098177     Document Type: Article

References (23)

1. Allèman, E., Doelker, E., & Gruny, R. (1993). Drug loaded poly (Lactic acid) nanoparticles produced by a reversible salting out process: Purification of an injectable dosage form. Euro. J. Pharm. Biopharm., 39, 13-18.
2. Ammoury, N., Fessi, H., Devissaguet, J. P., Allix, M., Plotkine, M., & Boulu, R. G. (1990). Effect on cerebral blood flow of orally administrated indomethacin-loaded poly(isobutylcyanoacrylate) and poly(DL-lactide) nanocapsules. J. Pharm. Pharmacol., 42, 558-561.
3. Ammoury, N., Fessi, H., Devissaguet, J. P., Dubrasquent, M., & Benita, S. (1991). Jejunal absorption, pharmacological activity, and pharmacokinetic evaluation of indomethacin loaded poly (DL-lactide) and poly(isobutylcyanoacrylate) nanoparticles in rats. Pharm. Res., 8, 101-105.
4. Boyd, B. J. (2005, Autumn/Winter). Colloidal delivery. Drug Deliv. Rep., 63-70.
5. Chiellini, E., Orisini, L. M., & Solaro, R. (2003). Polymeric nanoparticle based on polylactide and related copolymers. Macromol. Sym., 197, 345-354.
6. Dailey, L. A., & Kissel, T. (2005). New poly(lactic-co-glycolic acid) derivatives: Modular polymers with tailored properties. Drug Discovery Today Technologies, 2(1), 7-13.
7. Dalwadi, G., & Sunderland, V. B. (2007). Purification of PEGylated Nanoparticles using tangential flow filtration (TFF). Drug Dev. Ind. Pharm., 33(9), 1030-1039.
8. Dalwadi, G., Benson, H. A., & Chen, Y. (2005). Comparison of diafiltration and tangential flow filtration for purification of nanoparticle suspensions. Pharm. Res., 22(12), 2152-2162.
9. David, Q.-G., Eric, A. M., Hatem, F., & Erie, D. (1997). Applications of the ion-pair concept to hydrophilic substances with special emphasis on peptides. Pharm. Res., 14(2), 119-127.
10. Falk, R., Randolph, T. W., Meyer, J. D., Kelly, R. M., & Manning, M. C. (1997). Controlled release of ionic compounds from poly (D,L-lactide) microspheres produced by precipitation with a compressed antisolvent. J. Control. Release, 44(1), 77-85.
11. Fessi, H., Puisieux, F., Devissaguet, J. P., Ammoury, N., & Benita, S. (1989). Nanocapsules formation by interfacial polymer deposition follwing solvent displacement. Int. J. Pharm., 55, R1-R4.
12. Finely, J. H. (1961). Spectrophotometric determination of polyvinyl alcohol in paper coatings. Anal. Chem., 33, 1952-1957.
13. Govender, T., Stolnik, S., Garnett, M. C., Illum, L., & Davis, S. S. (1999). PLGA nanoparticles prepared by nanoprecipitation: Drug loading and release studies of a water soluble drug. J. Control. Release, 57(2), 171-185.
14. Heydenreich, A. V., Westmeier, R., Pedersen, N., Poulsen, H. S., & Kristensen, H. G. (2003). Preparation and purification of cationic solid lipid nanospheres - effects on particle size, physical stability and cell toxicity. Int. J. Pharm., 254(1), 83-87.
15. Illum, L., Khan, M. A., Mak, E., & Davis, S. S. (1986). Evaluation of carrier capacity and release characteristics for poly(butyl 2-cyanoacrylate) nanoparticles. Int. J. Pharm., 30, 17-28.
16. Magneheim, B., & Benita, S. (1991). Nanoparticle characterization: a comprehensive physicochemical approach. S.T.P. Pharma Sci., 4, 221-241.
17. Meyer, J. D., Matsuura, J. E., Kendrick, B. S., Evans, E. S., Evans, G. J., & Manning, M. C. (1995). Solution behavior of α-chymotrypsin dissolved in nonpolar organic solvents via hydrophobic ion pairing. Biopolymers, 35(5), 451-456.
18. Michalowski, C. B., Guterres, S. S., & Dalla Costa, T. (2004). Microdialysis for evaluating the entrapment and release of a lipophilic drug from nanoparticles. J. Pharm. Biomed. Anal., 35(5), 1093-1100.
19. Morawetz, H., & Hughes, W. L. (1951). The interaction of protein with synthetic polyelectrolytes. I. Complexing of bovine serum albumin. J.Phys. Chem., 56, 64-69.
20. Niwa, T., Takeuchi, H., Hino, T., Kunou, N., & Kawashima, Y. (1993). Preparations of biodegradable nanospheres of water-soluble and insoluble drugs with lactide/glycolide copolymer by a novel spontaneous emulsification solvent diffusion method, and the drug release behavior. J. Control. Release, 25(1-2), 89-98.
21. Niwa, T., Takeuchi, H., Hino, T., Kunou, N., & Kawashima, Y. (1994). In vitro drug release behaviour of D,L-lactide/glycolide copolymer (PLGA) nanosphere with nafarelin acetate by a novel spontaneous emulsification solvent diffusion method. J. Pharm. Sci., 83, 727-732.
22. Powers, M., Matsuura, J., Brassell, J., Manning, M. C., & Shefter, E. (1993). Enhanced solubility of proteins and peptides in nonpolar solvents through hydrophobic ion pairing. Biopolymers, 33(6), 927-932.
23. Riley, T., Govender, T., Stolnik, S., Xiong, C. D., Garnett, M. C., & Illum, L., et al. (1999). Colloidal stability and drug incorporation aspects of micellar-like PLA-PEG nanoparticles. Coll. Surf. B. Biointerf., 16(1-4), 147-159.