Blueberry antagonism of C-2 ceramide disruption of Ca2+ responses and recovery in MAChR-transfected COS-7 cell

Journal of Alzheimer's Disease

Volumn 15, Issue 3, 2008, Pages 429-441

  Joseph, James A ^a   Neuman, Anna ^a   Bielinski, Donna F ^a   Fisher, Derek R ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

Aging; Blueberry polyphenols; Ceramide; Muscarinic receptors; Oxidative stress

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; BLUEBERRY EXTRACT; CALCIUM; CERAMIDE; DOPAMINE; LIPID; MUSCARINIC RECEPTOR; OXOTREMORINE;

AGING; ALZHEIMER DISEASE; ARTICLE; BLUEBERRY; CELL MEMBRANE; CELL STRAIN COS7; CONTROLLED STUDY; DEPOLARIZATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL;

EID: 57349128444     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2008-15309     Document Type: Article

References (56)

1. F.M. Areias, A.C. Rego, C.R. Oliveira and R.M. Seabra, Antioxidant effect of flavonoids after ascorbate/Fe(2+)-induced oxidative stress in cultured retinal cells, Biochem Pharmacol 62 (2001), 111-118.
2. A. Arora, M.G. Nair and G.M. Strasburg, Structure-activity relationships for antioxidant activites of a series of flavonoids in a liposomal system, Free Radic Biol Med 24 (1998), 1355-1363.
3. S. Camandola, R.G. Cutler, D.S. Gary, O. Milhavet and M.P. Mattson, Suppression of calcium release from inositol 1,4,5-trisphosphate-sensitive stores mediates the antiapoptotic function of nuclear factor-kappaB, J Biol Chem 280 (2005), 22287-22296.
4. R.G. Cutler, J. Kelly, K. Storie, W.A. Pedersen, A. Tammara, K. Hatanpaa, J.C. Troncoso and M.P. Mattson, Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease, Proc Natl Acad Sci USA 101 (2004), 2070-2075.
5. R.G. Cutler and M.P. Mattson, Sphingomyelin and ceramide as regulators of development and lifespan, Mech Ageing Dev 122 (2001), 895-908.
6. P. De Sarno, S.A. Shestopal, T.D. King, A. Zmijewska, L. Song and R.S. Jope, Muscarinic receptor activation protects cells from apoptotic effects of DNA damage, oxidative stress, and mitochondrial inhibition, J Biol Chem 278 (2003), 11086-11093.
7. N.A. Denisova, D. Fisher, M. Provost and J.A. Joseph, The role of glutathione, membrane sphingomyelin, and its metabolites in oxidative stress-induced calciumdysregulation in PC12 cells, Free Radic Biol Med 27 (1999), 1292-1301.
8. N.A. Denisova, J.G. Strain and J.A. Joseph, Oxidant injury in PC12 cells-a possible model of calcium dysregulation in aging: II. Interactions with membrane lipids, J Neurochem 69 (1997), 1259-1266.
9. A. Elhusseiny, Z. Cohen, A. Olivier, D.B. Stanimirovic and E. Hamel, Functional acetylcholine muscarinic receptor subtypes in human brain microcirculation: identification and cellular localization, J Cereb Blood Flow Metab 19 (1999), 794-802.
10. L. Ginzburg, S.C. Li, Y.T. Li and A.H. Futerman, An exposed carboxyl group on sialic acid is essential for gangliosides to inhibit calcium uptake via the sarco/endoplasmic reticulum Ca2+-ATPase: relevance to gangliosidoses, J Neurochem 104 (2008), 140-146.
11. F.M. Goni, F.X. Contreras, L.R. Montes, J. Sot and A. Alonso, Biophysics (and sociology) of ceramides, Biochem Soc Symp (2005), 177-188.
12. I. Guillas, P.A. Kirchman, R. Chuard, M. Pfefferli, J.C. Jiang, S.M. Jazwinski and A. Conzelmann, C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p, EMBO J 20 (2001), 2655-2665.
13. Y.A. Hannun and L.M. Obeid, The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind, J Biol Chem 277 (2002), 25847-25850.
14. J.P. Herman, K.C. Chen, R. Booze and P.W. Landfield, Upregulation of alpha1D Ca2+ channel subunit mRNA expression in the hippocampus of aged F344 rats, Neurobiol Aging 19 (1998), 581-587.
15. J. Joseph, B. Shukitt-Hale, N.A. Denisova, A. Martin, G. Perry and M.A. Smith, Copernicus revisited: amyloid beta in Alzheimer's disease, Neurobiol Aging 22 (2001), 131-146.
16. J.A. Joseph, N. Denisova, D. Fisher, P. Bickford, R. Prior and G. Cao, Age-related neurodegeneration and oxidative stress: putative nutritional intervention, Neurol Clin 16 (1998), 747-755.
17. J.A. Joseph and D.R. Fisher, Muscarinic receptor subtype determines vulnerability to amyloid beta toxicity in transfected cos-7 cells, J Alzheimers Dis 5 (2003), 197-208.
18. J.A. Joseph, D.R. Fisher and D. Bielinski, Blueberry extract alters oxidative stress-mediated signaling in COS-7 cells transfected with selectively vulnerable muscarinic receptor subtypes, J Alzheimers Dis 9 (2006), 35-42.
19. J.A. Joseph, D.R. Fisher, A. Carey and A. Szprengiel, The M3 muscarinic receptor i3 domain confers oxidative stress protection on calcium regulation in transfected COS-7 cells, Aging Cell 3 (2004), 263-271.
20. J.A. Joseph, D.R. Fisher and A.N. Carey, Fruit extracts antagonize Abeta- or DA-induced deficits in Ca2+ flux in M1-transfected COS-7 cells, J Alzheimers Dis 6 (2004), 403-411; discussion 443-409.
21. J.A. Joseph, D.R. Fisher and J. Strain, Muscarinic receptor subtype determines vulnerability to oxidative stress in COS-7 cells, Free Radic Biol Med 32 (2002), 153-161.
22. J.A. Joseph, B. Shukitt-Hale, N.A. Denisova, D. Bielinski, A. Martin, J.J. McEwen and P.C. Bickford, Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation, J Neurosci 19 (1999), 8114-8121.
23. J.A. Joseph, R. Villalobos-Molina, N. Denisova, S. Erat, R. Cutler and J. Strain, Age differences in sensitivity to H2O2-or NO-induced reductions in K(+)-evoked dopamine release from superfused striatal slices: reversals by PBN or Trolox, Free Radic Biol Med 20 (1996), 821-830.
24. C. Kunzelmann-Marche, J.M. Freyssinet and M.C. Martinez, Loss of plasma membrane phospholipid asymmetry requires raft integrity. Role of transient receptor potential channels and ERK pathway, J Biol Chem 277 (2002), 19876-19881.
25. P.W. Landfield and J.C. Eldridge, The glucocorticoid hypothesis of age-related hippocampal neurodegeneration: role of dysregulated intraneuronal Ca2+, Ann N Y Acad Sci 746 (1994), 308-321.
26. F.C. Lau, D.F. Bielinski and J.A. Joseph, Inhibitory effects of blueberry extract on the production of inflammatory mediators in lipopolysaccharide- activated BV2 microglia, J Neurosci Res 85 (2007), 1010-1017.
27. S.Y. Lee, S.Z. Zhu and E.E. el-Fakahany, Role of two highly conserved tyrosine residues in the m1 muscarinic receptor second transmembrane domain in ligand binding and receptor function, Recept Signal Transduct 6 (1996), 43-52.
28. A.I. Levey, Muscarinic acetylcholine receptor expression in memory circuits: implications for treatment of Alzheimer disease, Proc Natl Acad Sci USA 93 (1996), 13541-13546.
29. S.A. Lightle, J.I. Oakley and M.N. Nikolova-Karakashian, Activation of sphingolipid turnover and chronic generation of ceramide and sphingosine in liver during aging, Mech Ageing Dev 120 (2000), 111-125.
30. A. Lopez-Revuelta, J.I. Sanchez-Gallego, A. Hernandez-Hernandez, J. Sanchez-Yague and M. Llanillo, Membrane cholesterol contents influence the protective effects of quercetin and rutin in erythrocytes damaged by oxidative stress, Chem Biol Interact 161 (2006), 79-91.
31. D.R. Lynch and T.M. Dawson, Secondary mechanisms in neuronal trauma see comments, Curr Opin Neurol 7 (1994), 510-516.
32. M.P. Mattson, C. Culmsee and Z.F. Yu, Apoptotic and antiapoptotic mechanisms in stroke, Cell Tissue Res 301 (2000), 173-187.
33. E. Meacci, V. Vasta, S. Neri, M. Farnararo and P. Bruni, Activation of phospholipase D in human fibroblasts by ceramide and sphingosine: evaluation of their modulatory role in bradykinin stimulation of phospholipase D, Biochem Biophys Res Commun 225 (1996), 392-399.
34. S.N. Meydani and D. Wu, Age-associated inflammatory changes: role of nutritional intervention, Nutr Rev 65 (2007), S213-216.
35. A. Morales, H. Lee, F.M. Goni, R. Kolesnick and J.C. Fernandez-Checa, Sphingolipids and cell death, Apoptosis 12 (2007), 923-939.
36. R.E. Mouton and M.E. Venable, Ceramide induces expression of the senescence histochemical marker, beta-galactosidase, in human fibroblasts, Mech Ageing Dev 113 (2000), 169-181.
37. N.A. Muma, R. Mariyappa, K. Williams and J.M. Lee, Differences in regional and subcellular localization of G(q/11) and RGS4 protein levels in Alzheimer's disease: correlation with muscarinic M1 receptor binding parameters, Synapse 47 (2003), 58-65.
38. L.M. Obeid and Y.A. Hannun, Ceramide, stress, and a LAG in aging, Sci Aging Knowledge Environ 2003 (2003), PE27.
39. P.I. Oteiza, A.G. Erlejman, S.V. Verstraeten, C.L. Keen and C.G. Fraga, Flavonoid-membrane interactions: a protective role of flavonoids at the membrane surface? Clin Dev Immunol 12 (2005), 19-25.
40. H.C. Ou, F.P. Chou, H.M. Sheen, T.M. Lin, C.H. Yang and W. Huey-Herng Sheu, Resveratrol, a polyphenolic compound in red wine, protects against oxidized LDL-induced cytotoxicity in endothelial cells, Clin Chim Acta 364 (2006), 196-204.
41. B. Pawlikowska-Pawlega, W.I. Gruszecki, L. Misiak, R. Paduch, T. Piersiak, B. Zarzyka, J. Pawelec and A. Gawron, Modification of membranes by quercetin, a naturally occurring flavonoid, via its incorporation in the polar head group, Biochim Biophys Acta 1768 (2007), 2195-2204.
42. L.J. Pike, Lipid rafts: bringing order to chaos, J Lipid Res 44 (2003), 655-667.
43. R. Rodriguez-Calvo, L. Serrano, E. Barroso, T. Coll, X. Palomer, A. Camins, R.M. Sanchez, M. Alegret, M. Merlos, M. Pallas, J.C. Laguna and M. Vazquez-Carrera, Peroxisome proliferator-activated receptor alpha down-regulation is associated with enhanced ceramide levels in age-associated cardiac hypertrophy, J Gerontol A Biol Sci Med Sci 62 (2007), 1326-1336.
44. S. Rossner, U. Ueberham, R. Schliebs, J.R. Perez-Polo and V. Bigl, The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling, Prog Neurobiol 56 (1998), 541-569.
45. H. Satoi, H. Tomimoto, R. Ohtani, T. Kitano, T. Kondo, M. Watanabe, N. Oka, I. Akiguchi, S. Furuya, Y. Hirabayashi and T. Okazaki, Astroglial expression of ceramide in Alzheimer's disease brains: a role during neuronal apoptosis, Neuroscience 130 (2005), 657-666.
46. K. Simons and E. Ikonen, How cells handle cholesterol, Science 290 (2000), 1721-1726.
47. B. Soreghan, S.N. Thomas and A.J. Yang, Aberrant sphingomyelin/ ceramide metabolic-induced neuronal endosomal/ lysosomal dysfunction: potential pathological consequences in age-related neurodegeneration, Adv Drug Deliv Rev 55 (2003), 1515-1524.
48. M.G. Tansey, R.H. Baloh, J. Milbrandt and E.M. Johnson, Jr., GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival, Neuron 25 (2000), 611-623.
49. E.C. Toescu and A. Verkhratsky, Parameters of calcium homeostasis in normal neuronal ageing, J Anat 197(Pt 4) (2000), 563-569.
50. R.C. Vannucci, R.M. Brucklacher and S.J. Vannucci, Intracellular calcium accumulation during the evolution of hypoxicischemic brain damage in the immature rat, Brain Res Dev Brain Res 126 (2001), 117-120.
51. M.E. Venable, G.C. Blobe and L.M. Obeid, Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence, J Biol Chem 269 (1994), 26040-26044.
52. M.E. Venable, J.Y. Lee, M.J. Smyth, A. Bielawska and L.M. Obeid, Role of ceramide in cellular senescence, J Biol Chem 270 (1995), 30701-30708.
53. W.G. Wood, F. Schroeder, U. Igbavboa, N.A. Avdulov and S.V. Chochina, Brain membrane cholesterol domains, aging and amyloid beta-peptides, Neurobiol Aging 23 (2002), 685-694.
54. D. Wu, Z. Ren, M. Pae, W. Guo, X. Cui, A.H. Merrill and S.N. Meydani, Aging up-regulates expression of inflammatory mediators in mouse adipose tissue, J Immunol 179 (2007), 4829-4839.
55. R.A. Zager, Hypoperfusion-induced acute renal failure in the rat: an evaluation of oxidant tissue injury, Circ Res 62 (1988), 430-435.
56. T.L. Zern, R.J. Wood, C. Greene, K.L. West, Y. Liu, D. Aggarwal, N.S. Shachter and M.L. Fernandez, Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress, J Nutr 135 (2005), 1911-1917.