PPARα activation and increased dietary lipid oppose thyroid hormone signaling and rescue impaired glucose-stimulated insulin secretion in hyperthyroidism

American Journal of Physiology - Endocrinology and Metabolism

Volumn 295, Issue 6, 2008, Pages

  Holness, Mark J ^a,b   Greenwood, Gemma K ^a   Smith, Nicholas D ^a   Sugden, Mary C ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b Institute of Cell and Molecular Science   (United Kingdom)

Author keywords

Fasting; Fat feeding; Islet function; Peroxisome proliferator activated receptor ; Thyroid hormone action

Indexed keywords

GLUCOSE; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PIRINIXIC ACID; THYROID HORMONE; THYROID HORMONE RECEPTOR; ANTITHYROID AGENT; HYPOCHOLESTEROLEMIC AGENT; LIPID; PYRIMIDINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOHYDRATE DIET; CONTROLLED STUDY; FAT INTAKE; FEMALE; GLUCOSE TOLERANCE; HORMONAL REGULATION; HORMONE RESPONSE; HYPERGLYCEMIA; HYPERTHYROIDISM; IN VIVO STUDY; INSULIN RELEASE; INSULIN RESISTANCE; LIPID DIET; LOW FAT DIET; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; STARVATION; ANIMAL; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; DRUG POTENTIATION; EATING; GLUCOSE INTOLERANCE; METABOLISM; PANCREAS ISLET BETA CELL; PHYSIOLOGY; SECRETION; WISTAR RAT;

ANIMALS; ANTICHOLESTEREMIC AGENTS; ANTITHYROID AGENTS; DIETARY FATS; EATING; FEMALE; GLUCOSE; GLUCOSE INTOLERANCE; HYPERTHYROIDISM; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; LIPIDS; PPAR ALPHA; PYRIMIDINES; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; STARVATION; THYROID HORMONES;

EID: 57349126931     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.90700.2008     Document Type: Article

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