Wagner et al. reply

Nature

Volumn 456, Issue 7222, 2008, Pages

  Wagner, Günter P ^a   Kenney Hunt, Jane P ^b   Pavlicev, Mihaela ^b   Peck, Joel R ^c   Waxman, David ^c   Cheverud, James M ^b  

^a YALE UNIVERSITY   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GENE MAPPING; GENE MUTATION; GENOTYPE; NOTE; PLEIOTROPY; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS;

EID: 57349126305     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature07453     Document Type: Note

References (6)

1. Wagner, G. P. et al. Pleiotropic scaling of gene effects and the 'cost of complexity'. Nature 452, 470-472 (2008).
2. Orr, H. A. Adaptation and the cost of complexity. Evolution Int. J. Org. Evolution 54, 13-20 (2000).
3. Wingreen, N. S., Miller, J. & Cox, E. C. Scaling of mutational effects in models of pleiotropy. Genetics 164, 1221-1228 (2003).
4. Turelli, M. Effects of pleiotropy on predictions concerning mutation-selection balance for polygenic traits. Genetics 111, 165-195 (1985).
5. Wagner, G. P. The influence of variation and of developmental constraints on the rate of multivariate phenotypic evolution. J. Evol. Biol. 1, 45-66 (1988).
6. Hermisson, J. & McGregor, A. P. Pleiotropic scaling and QTL data. Nature 456, doi:10.1038/nature07452 (2008).