Physical activity: Does long-term, high-intensity exercise in horses result in tendon degeneration?

Journal of Applied Physiology

Volumn 105, Issue 6, 2008, Pages 1927-1933

  Birch, Helen L ^a   Wilson, Alan M ^b   Goodship, Allen E ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

Extracellular matrix; Ligament; Physical training

Indexed keywords

COLLAGEN FIBRIL; COLLAGEN TYPE 1; COLLAGEN TYPE 2; COLLAGEN TYPE 3; GLYCOSAMINOGLYCAN POLYSULFATE;

ADAPTATION; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMMON DIGITAL EXTENSOR TENDON; DEEP DIGITAL FLEXOR TENDON; DEGENERATION; DNA DETERMINATION; EXERCISE INTENSITY; EXPERIMENTAL MODEL; EXTRACELLULAR MATRIX; FEMALE; FLUORESCENCE; HORSE; LIGAMENT; NONHUMAN; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN CROSS LINKING; SUPERFICIAL DIGITAL FLEXOR TENDON; SUSPENSORY LIGAMENT; TENDON; TENDON DEGENERATION; TENDON INJURY; TISSUE LEVEL; WALKING; WATER CONTENT; YOUNG MODULUS;

ANIMALS; BIOMECHANICS; BODY WATER; COLLAGEN; DNA; ELASTICITY; EXTREMITIES; FEMALE; GLYCOSAMINOGLYCANS; HORSES; MICROSCOPY, FLUORESCENCE; PHYSICAL CONDITIONING, ANIMAL; TENDON INJURIES;

EID: 57349116986     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00717.2007     Document Type: Article

References (55)

1. Amiel D, Woo SL, Harwood FL, Akeson WH. The effect of immobilization on collagen turnover in connective tissue: a biochemical- biomechanical correlation. Acta Orthop Scand 53: 325-332, 1982.
2. Bank RA, TeKoppele JM, Oostingh G, Hazleman BL, Riley GP. Lysylhydroxylation and nonreducible crosslinking of human supraspinatus tendon collagen: changes with age and in chronic rotator cuff tendinitis. Ann Rheum Dis 58: 35-41, 1999.
3. Birch HL, Bailey AJ, Goodship AE. Macroscopic " degeneration" of equine superficial digital flexor tendon is accompanied by a change in extracellular matrix composition. Equine Vet J 30: 534-539, 1998.
4. Birch HL, Bailey JV, Bailey AJ, Goodship AE. Age-related changes to the molecular and cellular components of equine flexor tendons. Equine Vet J 31: 391-396, 1999.
5. Birch HL, McLaughlin L, Smith RK, Goodship AE. Treadmill exercise-induced tendon hypertrophy: assessment of tendons with different mechanical functions. Equine Vet J Suppl 30: 222-226, 1999.
6. Buchanan CI, Marsh RL. Effects of long-term exercise on the biomechanical properties of the Achilles tendon of guinea fowl. J Appl Physiol 90: 164-171, 2001.
7. Chakravarti S. Functions of lumican and fibromodulin: lessons from knockout mice. Glycoconj J 19: 287-293, 2002.
8. Danielson KG, Baribault H, Holmes DF, Graham H, Kadler KE, Iozzo RV. Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility. J Cell Biol 136: 729-743, 1997.
9. Edwards LJ, Goodship AE, Birch HL, Patterson-Kane JC. Effect of exercise on age-related changes in collagen fibril diameter distributions in the common digital extensor tendons of young horses. Am J Vet Res 66: 564-568, 2005.
10. Ely ER, Verheyen KL, Wood JL. Fractures and tendon injuries in National Hunt horses in training in the UK: a pilot study. Equine Vet J 36: 365-367, 2004.
11. Farndale RW, Buttle DJ, Barrett AJ. Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta 883: 173-177, 1986.
12. Fransen M, McConnell S, Bell M. Exercise for osteoarthritis of the hip or knee. Cochrane Database Syst Rev CD004286, 2003.
13. Hansen P, Aagaard P, Kjaer M, Larsson B, Magnusson SP. Effect of habitual running on human Achilles tendon load-deformation properties and cross-sectional area. J Appl Physiol 95: 2375-2380, 2003.
14. Houshian S, Tscherning T, Riegels-Nielsen P. The epidemiology of Achilles tendon rupture in a Danish county. Injury 29: 651-654, 1998.
15. Jepsen KJ, Wu F, Peragallo JH, Paul J, Roberts L, Ezura Y, Oldberg A, Birk DE, Chakravarti S. A syndrome of joint laxity and impaired tendon integrity in lumican- and fibromodulin-deficient mice. J Biol Chem 277: 35532-35540, 2002.
16. Kannus P. Tendons-a source of major concern in competitive and recreational athletes. Scand J Med Sci Sports 7: 53-54, 1997.
17. Kannus P, Jozsa L. Histopathological changes preceding spontaneous rupture of a tendon. A controlled study of 891 patients. J Bone Joint Surg Am 73: 1507-1525, 1991.
18. Kasashima Y, Takahashi T, Smith RK, Goodship AE, Kuwano A, Ueno T, Hirano S. Prevalence of superficial digital flexor tendonitis and suspensory desmitis in Japanese Thoroughbred flat racehorses in 1999. Equine Vet J 36: 346-350, 2004.
19. Kim YJ, Sah RL, Doong JY, Grodzinsky AJ. Fluorometric assay of DNA in cartilage explants using Hoechst 33258. Anal Biochem 174: 168-176, 1988.
20. Kjaer M. Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading. Physiol Rev 84: 649-698, 2004.
21. Koskinen SO, Heinemeier KM, Olesen JL, Langberg H, Kjaer M. Physical exercise can influence local levels of matrix metalloproteinases and their inhibitors in tendon-related connective tissue. J Appl Physiol 96: 861-864, 2004.
22. Kubo K, Kanehisa H, Ito M, Fukunaga T. Effects of isometric training on the elasticity of human tendon structures in vivo. J Appl Physiol 91: 26-32, 2001.
23. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970.
24. Langberg H, Bulow J, Kjaer M. Blood flow in the peritendinous space of the human Achilles tendon during exercise. Acta Physiol Scand 163: 149-153, 1998.
25. Langberg H, Rosendal L, Kjaer M. Training-induced changes in peritendinous type I collagen turnover determined by microdialysis in humans. J Physiol 534: 297-302, 2001.
26. Light ND, Bailey AJ. The chemistry of the collagen cross-links. Purification and characterization of cross-linked polymeric peptide material from mature collagen containing unknown amino acids. Biochem J 185: 373-381, 1980.
27. Maffulli N, Khan KM, Puddu G. Overuse tendon conditions: time to change a confusing terminology. Arthroscopy 14: 840-843, 1998.
28. Magnusson SP, Kjaer M. Region-specific differences in Achilles tendon cross-sectional area in runners and non-runners. Eur J Appl Physiol 90: 549-553, 2003.
29. Michna H. Morphometric analysis of loading-induced changes in collagen-fibril populations in young tendons. Cell Tissue Res 236: 465-470, 1984.
30. Moller A, Astron M, Westlin N. Increasing incidence of Achilles tendon rupture. Acta Orthop Scand 67: 479-481, 1996.
31. Munneke M, de Jong Z, Zwinderman AH, Ronday HK, van Schaardenburg D, Dijkmans BA, Kroon HM, Vliet Vlieland TP, Hazes JM. Effect of a high-intensity weight-bearing exercise program on radiologic damage progression of the large joints in subgroups of patients with rheumatoid arthritis. Arthritis Rheum 53: 410-417, 2005.
32. Nielsen HM, Skalicky M, Viidik A. Influence of physical exercise on aging rats. III. Life-long exercise modifies the aging changes of the mechanical properties of limb muscle tendons. Mech Ageing Dev 100: 243-260, 1998.
33. Parry DA, Barnes GR, Craig AS. A comparison of the size distribution of collagen fibrils in connective tissues as a function of age and a possible relation between fibril size distribution and mechanical properties. Proc R Soc Lond B Biol Sci 203: 305-321, 1978.
34. Patterson-Kane JC, Firth EC, Parry DA, Wilson AM, Goodship AE. Effects of training on collagen fibril populations in the suspensory ligament and deep digital flexor tendon of young thoroughbreds. Am J Vet Res 59: 64-68, 1998.
35. Patterson-Kane JC, Wilson AM, Firth EC, Parry DA, Goodship AE. Comparison of collagen fibril populations in the superficial digital flexor tendons of exercised and nonexercised thoroughbreds. Equine Vet J 29: 121-125, 1997.
36. Pinchbeck GL, Clegg PD, Proudman CJ, Stirk A, Morgan KL, French NP. Horse injuries and racing practices in National Hunt racehorses in the UK: the results of a prospective cohort study. Vet J 167: 45-52, 2004.
37. Puddu G, Ippolito E, Postacchini F. A classification of Achilles tendon disease. Am J Sports Med 4: 145-150, 1976.
38. Reeves ND, Maganaris CN, Narici MV. Effect of strength training on human patella tendon mechanical properties of older individuals. J Physiol 548: 971-981, 2003.
39. Riley GP, Harrall RL, Constant CR, Chard MD, Cawston TE, Hazleman BL. Glycosaminoglycans of human rotator cuff tendons: changes with age and in chronic rotator cuff tendinitis. Ann Rheum Dis 53: 367-376, 1994.
40. Riley GP, Harrall RL, Constant CR, Chard MD, Cawston TE, Hazleman BL. Tendon degeneration and chronic shoulder pain: changes in the collagen composition of the human rotator cuff tendons in rotator cuff tendinitis. Ann Rheum Dis 53: 359-366, 1994.
41. Rosager S, Aagaard P, Dyhre-Poulsen P, Neergaard K, Kjaer M, Magnusson SP. Load-displacement properties of the human triceps surae aponeurosis and tendon in runners and non-runners. Scand J Med Sci Sports 12: 90-98, 2002.
42. Sims TJ, Bailey AJ. Quantitative analysis of collagen and elastin crosslinks using a single-column system. J Chromatogr 582: 49-55, 1992.
43. Smith RK, Birch H, Patterson-Kane J, Firth EC, Williams L, Cherdchutham W, van Weeren WR, Goodship AE. Should equine athletes commence training during skeletal development? Changes in tendon matrix associated with development, ageing, function and exercise. Equine Vet J Suppl 30: 201-209, 1999.
44. Smith TJ. The Relationship Between Tendon Morphology and Function (Dissertation). London: University College, 2006.
45. Sommer HM. The biomechanical and metabolic effects of a running regime on the Achilles tendon in the rat. Int Orthop 11: 71-75, 1987.
46. Strocchi R, De Pasquale V, Guizzardi S, Govoni P, Facchini A, Raspanti M, Girolami M, Giannini S. Human Achilles tendon: morphological and morphometric variations as a function of age. Foot Ankle 12: 100-104, 1991.
47. Svensson L, Aszodi A, Reinholt FP, Fassler R, Heinegard D, Oldberg A. Fibromodulin-null mice have abnormal collagen fibrils, tissue organization, and altered lumican deposition in tendon. J Biol Chem 274: 9636-9647, 1999.
48. Thomas KS, Muir KR, Doherty M, Jones AC, O'Reilly SC, Bassey EJ. Home based exercise programme for knee pain and knee osteoarthritis: randomised controlled trial. BMJ 325: 752, 2002.
49. Vogel KG, Meyers AB. Proteins in the tensile region of adult bovine deep flexor tendon. Clin Orthop Relat Res 367, Suppl: S344-S355, 1999.
50. Webbon PM. A post mortem study of equine digital flexor tendons. Equine Vet J 9: 61-67, 1977.
51. Williams RB, Harkins LS, Hammond CJ, Wood JL. Racehorse injuries, clinical problems and fatalities recorded on British racecourses from flat racing and National Hunt racing during 1996, 1997 and 1998. Equine Vet J 33: 478-486, 2001.
52. Wilson AM, McGuigan MP, Su A, van Den Bogert AJ. Horses damp the spring in their step. Nature 414: 895-899, 2001.
53. Woo SL, Gomez MA, Amiel D, Ritter MA, Gelberman RH, Akeson WH. The effects of exercise on the biomechanical and biochemical properties of swine digital flexor tendons. J Biomech Eng 103: 51-56, 1981.
54. Woo SL, Ritter MA, Amiel D, Sanders TM, Gomez MA, Kuei SC, Garfin SR, Akeson WH. The biomechanical and biochemical properties of swine tendons; long term effects of exercise on the digital extensors. Connect Tissue Res 7: 177-183, 1980.
55. Ying M, Yeung E, Li B, Li W, Lui M, Tsoi CW. Sonographic evaluation of the size of Achilles tendon: the effect of exercise and dominance of the ankle. Ultrasound Med Biol 29: 637-642, 2003.