A comparison of fluoroquinolone penetration into human conjunctival tissue

Journal of Ocular Pharmacology and Therapeutics

Volumn 24, Issue 6, 2008, Pages 587-591

  Aihara, Makoto ^a   Miyanaga, Masaru ^b   Minami, Keiichiro ^b   Miyata, Kazunori ^b   Eguchi, Shuichiro ^c   Shiroma, Hiroki ^d   Sawaguchi, Shoichi ^d  

^a UNIVERSITY OF TOKYO   (Japan)

^b Miyata Eye Hospital   (Japan)

^c Eguchi Eye Hospital   (Japan)

^d UNIVERSITY OF THE RYUKYUS SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BENZALKONIUM CHLORIDE; GATIFLOXACIN; LEVOFLOXACIN; MOXIFLOXACIN; QUINOLONE DERIVATIVE;

ADULT; AGED; ARTICLE; CONCENTRATION RESPONSE; CONJUNCTIVA; DOSE TIME EFFECT RELATION; DRUG PENETRATION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PTERYGIUM; TISSUE DISTRIBUTION;

ADULT; AGED; ANTI-INFECTIVE AGENTS; AZA COMPOUNDS; CONJUNCTIVA; FEMALE; FLUOROQUINOLONES; HUMANS; MALE; MIDDLE AGED; OFLOXACIN; QUINOLINES;

EID: 57349113776     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/jop.2008.0055     Document Type: Article

References (17)

1. Mather, R., Stewart, J.M., Prabriputaloong, T., et al. The effect of cataract surgery on ocular levels of topical moxifloxacin. Am. J. Ophthalmol. 138:554-559, 2004.
2. Dalhoff, A., and Schmitz, F.J. In vitro antibacterial activity and pharmacodynamics of new quinolones. Eur. J. Clin. Microbiol. Infect. Dis. 22:203-221, 2003.
3. Blondeau, J.M., Zhao, X., Hansen, G., et al. Mutant prevention concentrations of fluoroquinolones for clinical isolates of Streptococcus pneumoniae. Antimicrob. Agents Chemother. 45:433-438, 2001.
4. Hedlin, P., and Blondeau, J.M. Comparative minimal inhibitory and mutant prevention drug concentrations of four fluoroquinolones against ocular isolates of Haemophilus influenzae. Eye Contact Lens 33:161-164, 2007.
5. Ong-Tone, L. Aqueous humor penetration of gatifloxacin and moxifloxacin eyedrops given by different methods before cataract surgery. J. Cataract Refract. Surg. 33:59-62, 2007.
6. McCulley, J.P., Caudle, D., Aronowicz, J.D., et al. Fourth-generation fluoroquinolone penetration into the aqueous humor in humans. Ophthalmology 113:955-959, 2006.
7. Kim, D.H., Stark, W.J., and O'Brien, T.P. Ocular penetration of moxifloxacin 0.5% and gatifloxacin 0.3% ophthalmic solutions into the aqueous humor following topical administration prior to routine cataract surgery. Curr. Med. Res. Opin. 21:93-94, 2005.
8. Wagner, R.S., Abelson, M.B., Shapiro, A., et al. Evaluation of moxifloxacin, ciprofloxacin, gatifloxacin, ofloxacin, and levofloxacin concentrations in human conjunctival tissue. Arch. Ophthalmol. 123:1282-1283, 2005.
9. Sasaki, H., Nagano, T., Yamamura, K., et al. Ophthalmic preservatives as absorption promoters for ocular drug delivery. J. Pharm. Pharmacol. 47:703-707, 1995.
10. Solomon, R., Donnenfeld, E.D., Perry, H.D., et al. Penetration of topically applied gatifloxacin 0.3%, moxifloxacin 0.5%, and ciprofloxacin 0.3% into the aqueous humor. Ophthalmology 112:466-469, 2005.
11. Owen, G.R., Brooks, A.C., James, O., et al. A novel in vivo rabbit model that mimics human dosing to determine the distribution of antibiotics in ocular tissues. J. Ocul. Pharmacol. Ther. 23:335-342, 2007.
12. Katz, H.R., Masket, S., Lane, S.S., et al. Absorption of topical moxifloxacin ophthalmic solution into human aqueous humor. Cornea 24:955-958, 2005.
13. Liu, W., Liu, Q.F., Perkins, R., et al. Pharmacokinetics of sparfloxacin in the serum and vitreous humor of rabbits: Physicochemical properties that regulate penetration of quinolone antimicrobials. Antimicrob. Agents Chemother. 42:1417-1423, 1998.
14. Robertson, S.M., Curtis, M.A., Schlech, B.A., et al. Ocular pharmacokinetics of moxifloxacin after topical treatment of animals and humans. Surv. Ophthalmol. 50(Suppl 1):S32-S45, 2005.
15. Fukuda, M., and Sasaki, K. [In vitro topically applied fluoroquinolone penetration into the anterior chamber]. Nippon Ganka Gakkai Zasshi. 99:532-536, 1995.
16. Cha, S.H., Lee, J.S., Oum, B.S., et al. Corneal epithelial cellular dysfunction from benzalkonium chloride (BAC) in vitro. Clin. Exp. Ophthalmol. 32:180-184, 2004.
17. Ishibashi, T., Yokoi, N., and Kinoshita, S. Comparison of the short-term effects on the human corneal surface of topical timolol maleate with and without benzalkonium chloride. J. Glaucoma 12:486-490, 2003.