Application of semiparametric mixed models and simultaneous confidence bands in a cardiovascular safety experiment with longitudinal data

Journal of Biopharmaceutical Statistics

Volumn 18, Issue 6, 2008, Pages 1043-1062

  Maringwa, John T ^a   Geys, Helena ^a,b   Shkedy, Ziv ^a   Faes, Christel ^a   Molenberghs, Geert ^a   Aerts, Marc ^a   Ammel, Karel Van ^b   Teisman, Ard ^b   Bijnens, Luc ^b  

^a HASSELT UNIVERSITY   (Belgium)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Penalized splines; Semiparametric mixed models; Simultaneous confidence bands; Smoothing

Indexed keywords

ARTICLE; CARDIOVASCULAR SYSTEM; DOG; HEART ARRHYTHMIA; HEART RATE; LONGITUDINAL STUDY; NONHUMAN; PRIORITY JOURNAL; QT INTERVAL; QT PROLONGATION; STATISTICAL ANALYSIS; STATISTICAL MODEL;

ANIMALS; CONFIDENCE INTERVALS; DATA INTERPRETATION, STATISTICAL; DRUG EVALUATION, PRECLINICAL; HEART RATE; LINEAR MODELS; LONG QT SYNDROME; LONGITUDINAL STUDIES; MODELS, ANIMAL; MODELS, STATISTICAL; REPRODUCIBILITY OF RESULTS; TIME FACTORS; TREATMENT OUTCOME;

EID: 57349112356     PISSN: 10543406     EISSN: 15205711     Source Type: Journal    
DOI: 10.1080/10543400802368881     Document Type: Article

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