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Volumn 54, Issue 6, 2008, Pages 629-637

Studies on 1-(2-phenethyl)-4-(N-propionylanilino)piperidine (fentanyl) and its related compounds: Novel metabolites in rat urine following injection of α-methylfentanyl, one of the most abused typical designer drugs

Author keywords

methylfentanyl; Designer drug; Forensic; GC MS; Metabolite

Indexed keywords

ALPHA METHYLFENTANYL; DESIGNER DRUG; FENTANYL DERIVATIVE; UNCLASSIFIED DRUG;

EID: 57349109981     PISSN: 13449702     EISSN: 13475207     Source Type: Journal    
DOI: 10.1248/jhs.54.629     Document Type: Article
Times cited : (12)

References (22)
  • 1
    • 0019794225 scopus 로고
    • Structure of bogus "China White" solved
    • Stinson, S. (1981) Structure of bogus "China White" solved. Chem. Eng. News, 19, 71-72.
    • (1981) Chem. Eng. News , vol.19 , pp. 71-72
    • Stinson, S.1
  • 2
    • 0019626832 scopus 로고
    • Behind the identification of China White
    • Kram, T. C., Cooper, D. A. and Allen, A. C. (1981) Behind the identification of China White. Anal. Chem., 53, 1379A-1386A.
    • (1981) Anal. Chem , vol.53
    • Kram, T.C.1    Cooper, D.A.2    Allen, A.C.3
  • 3
    • 0000198962 scopus 로고
    • Structural information from tandem mass spectrometry for China White and related fentanyl derivatives
    • Cheng, M. T., Kruppa, G. H. and McLafferty, F. W. (1982) Structural information from tandem mass spectrometry for China White and related fentanyl derivatives. Anal. Chem., 54, 2204-2207.
    • (1982) Anal. Chem , vol.54 , pp. 2204-2207
    • Cheng, M.T.1    Kruppa, G.H.2    McLafferty, F.W.3
  • 4
    • 0022365049 scopus 로고
    • New variety of street drugs poses growing problem. Designer drugs - analogs of compounds with proven pharmacological activity made by underground chemists - present novel challenges to law enforcement officials, legislators, and scientists
    • Baum, R. M. (1985) New variety of street drugs poses growing problem. Designer drugs - analogs of compounds with proven pharmacological activity made by underground chemists - present novel challenges to law enforcement officials, legislators, and scientists. Chem. Eng. News, 9, 7-16.
    • (1985) Chem. Eng. News , vol.9 , pp. 7-16
    • Baum, R.M.1
  • 5
    • 45849118067 scopus 로고
    • Designer drugs
    • Shafer, J. (1985) Designer drugs. Science, 85, 60-67.
    • (1985) Science , vol.85 , pp. 60-67
    • Shafer, J.1
  • 6
    • 0022473074 scopus 로고    scopus 로고
    • Cooper, D. A, Jacob, M. and Allen, A. C. (1986) Identification of fentanyl derivatives. J. Forensic Sci., 31, 511-528.
    • Cooper, D. A, Jacob, M. and Allen, A. C. (1986) Identification of fentanyl derivatives. J. Forensic Sci., 31, 511-528.
  • 7
    • 0022636622 scopus 로고
    • Studies on 1-(2-phenethyl)-4-(N-propionylanilino) piperidine (fentanyl) and related compounds. I. Spectroscopic and chromatographic analysis of 3-methylfentanyl and α-methylfentanyl
    • Suzuki, S., Inoue, T. and Kashima, C. (1986) Studies on 1-(2-phenethyl)-4-(N-propionylanilino) piperidine (fentanyl) and related compounds. I. Spectroscopic and chromatographic analysis of 3-methylfentanyl and α-methylfentanyl. Chem. Pharm. Bull. (Tokyo), 34, 1340-1343.
    • (1986) Chem. Pharm. Bull. (Tokyo) , vol.34 , pp. 1340-1343
    • Suzuki, S.1    Inoue, T.2    Kashima, C.3
  • 8
    • 0024439576 scopus 로고
    • Studies on fentanyl and related compounds. II. Spectrometric discrimination of five mono methylated fentanyl isomers by gas chromatography/ Fourier transform-infrared spectrometry
    • Suzuki, S. (1989) Studies on fentanyl and related compounds. II. Spectrometric discrimination of five mono methylated fentanyl isomers by gas chromatography/ Fourier transform-infrared spectrometry. Forensic Sci. Int., 43, 15-19.
    • (1989) Forensic Sci. Int , vol.43 , pp. 15-19
    • Suzuki, S.1
  • 9
    • 0001752221 scopus 로고
    • Studies on 1-(2-phenethyl)-4-(N-propionylanilino) piperidine (fentanyl) and related compounds. III. Effect of methyl group introduction into fentanyl on sensitivity enhancement in gas chromatography with surface ionization detection
    • Suzuki, S., Tsuchihashi, H. and Arimoto, H. (1989) Studies on 1-(2-phenethyl)-4-(N-propionylanilino) piperidine (fentanyl) and related compounds. III. Effect of methyl group introduction into fentanyl on sensitivity enhancement in gas chromatography with surface ionization detection. J. Chromatogr. A, 475, 400-403.
    • (1989) J. Chromatogr. A , vol.475 , pp. 400-403
    • Suzuki, S.1    Tsuchihashi, H.2    Arimoto, H.3
  • 10
    • 0032777781 scopus 로고    scopus 로고
    • Studies on fentanyl and related compounds. IV. Chromatographic and spectrometric discrimination of fentanyl and its derivatives
    • Ohta, H., Suzuki, S. and Ogasawara, K. (1999) Studies on fentanyl and related compounds. IV. Chromatographic and spectrometric discrimination of fentanyl and its derivatives. J. Anal. Toxicol., 23, 280-285.
    • (1999) J. Anal. Toxicol , vol.23 , pp. 280-285
    • Ohta, H.1    Suzuki, S.2    Ogasawara, K.3
  • 11
    • 0001034455 scopus 로고
    • The metabolism and excretion of the analgesic fentanyl (R 4263) by Wistar rats
    • Van Wijngaarden, I. and Soudijn, W. (1968) The metabolism and excretion of the analgesic fentanyl (R 4263) by Wistar rats. Life Sci., 7, 1239-1244.
    • (1968) Life Sci , vol.7 , pp. 1239-1244
    • Van Wijngaarden, I.1    Soudijn, W.2
  • 12
    • 0014526720 scopus 로고
    • Studies on the fate of fentanyl
    • Maruyama, Y. and Hosoya, E. (1969) Studies on the fate of fentanyl. Keio J. Med., 18, 59-70.
    • (1969) Keio J. Med , vol.18 , pp. 59-70
    • Maruyama, Y.1    Hosoya, E.2
  • 15
    • 0019829884 scopus 로고
    • The assay of fentanyl and its metabolites in plasma of patients using gas chromatography with alkali flame ionization detection and gas chromatography-mass spectrometry
    • Van Rooy, H. H., Vermeulen, N. P. E. and Bovill, J. G. (1983) The assay of fentanyl and its metabolites in plasma of patients using gas chromatography with alkali flame ionization detection and gas chromatography-mass spectrometry. J. Chromatogr. B, 223, 85-93.
    • (1983) J. Chromatogr. B , vol.223 , pp. 85-93
    • Van Rooy, H.H.1    Vermeulen, N.P.E.2    Bovill, J.G.3
  • 16
    • 0019976584 scopus 로고
    • Identification of fentanyl metabolites in rat urine by gas chromatography-mass spectrometry with stable-isotope tracers
    • Goroumaru, T., Matsuura, H., Furuta, T., Baba, S., Yoshimura, N., Miyawaki, T. and Sameshima, T. (1982) Identification of fentanyl metabolites in rat urine by gas chromatography-mass spectrometry with stable-isotope tracers. Drug Metab. Dispos., 10, 542-546.
    • (1982) Drug Metab. Dispos , vol.10 , pp. 542-546
    • Goroumaru, T.1    Matsuura, H.2    Furuta, T.3    Baba, S.4    Yoshimura, N.5    Miyawaki, T.6    Sameshima, T.7
  • 17
    • 0021152878 scopus 로고
    • Identification and quantitative determination of fentanyl metabolites in patients by gas chromatography-mass spectrometry
    • Goroumaru, T., Matsuura, H., Yoshimura, N., Miyawaki, T., Sameshima, T., Miyao, J., Furuta, T. and Baba, S. (1984) Identification and quantitative determination of fentanyl metabolites in patients by gas chromatography-mass spectrometry. Anesthesiology, 61, 73-77.
    • (1984) Anesthesiology , vol.61 , pp. 73-77
    • Goroumaru, T.1    Matsuura, H.2    Yoshimura, N.3    Miyawaki, T.4    Sameshima, T.5    Miyao, J.6    Furuta, T.7    Baba, S.8
  • 19
    • 0029813838 scopus 로고    scopus 로고
    • Metabolism of fentanyl, a synthetic opioid analgesic, by human liver microsomes. Role of CYP3A4
    • Feierman, D. E. and Lasker, J. M. (1996) Metabolism of fentanyl, a synthetic opioid analgesic, by human liver microsomes. Role of CYP3A4. Drug. Metab. Dispos., 24, 932-939.
    • (1996) Drug. Metab. Dispos , vol.24 , pp. 932-939
    • Feierman, D.E.1    Lasker, J.M.2
  • 20
    • 0030774527 scopus 로고    scopus 로고
    • Fentanyl metabolism by human hepatic and intestinal cytochrome P-450 3A4: Implications for interindividual variability in disposition, efficacy and drug interactions
    • Labroo, R. B., Paine, M. F., Thummel, K. E. and Kharasch, E. D. (1997) Fentanyl metabolism by human hepatic and intestinal cytochrome P-450 3A4: implications for interindividual variability in disposition, efficacy and drug interactions. Drug Metab. Dispos., 25, 1072-1080.
    • (1997) Drug Metab. Dispos , vol.25 , pp. 1072-1080
    • Labroo, R.B.1    Paine, M.F.2    Thummel, K.E.3    Kharasch, E.D.4
  • 21
    • 0021237989 scopus 로고
    • Optimization of the radioimmunoassays for measuring fentanyl and alfentanil in human serum
    • Schuttler, J. and White, P. F. (1984) Optimization of the radioimmunoassays for measuring fentanyl and alfentanil in human serum. Anesthesiology, 61, 315-320.
    • (1984) Anesthesiology , vol.61 , pp. 315-320
    • Schuttler, J.1    White, P.F.2
  • 22
    • 40149089875 scopus 로고    scopus 로고
    • Studies on 1-(2-phenethyl)-4-(N- propionylanilino)piperidine (fentanyl) and its related compounds. VI. Structure-analgesic activity relationship for fentanyl, methyl-substituted fentanyls and other analogues
    • Higashikawa, Y. and Suzuki, S. (2008) Studies on 1-(2-phenethyl)-4-(N- propionylanilino)piperidine (fentanyl) and its related compounds. VI. Structure-analgesic activity relationship for fentanyl, methyl-substituted fentanyls and other analogues. Forensic Toxicology, 26, 1-5.
    • (2008) Forensic Toxicology , vol.26 , pp. 1-5
    • Higashikawa, Y.1    Suzuki, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.