In vitro cytotoxicity of functionalized single walled carbon nanotubes for targeted gene delivery applications

Nanotoxicology

Volumn 2, Issue 4, 2008, Pages 184-188

  Kulamarva, Arun ^a   Bhathena, Jasmine ^a   Malhotra, Meenakshi ^a   Sebak, Safaa ^a   Nalamasu, Omkaram ^b   Ajayan, Pulickel ^c   Prakash, Satya ^a,d  

^a MCGILL UNIVERSITY   (Canada)

^b APPLIED MATERIALS INC   (United States)

^c Rice University   (United States)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

Cytotoxicity; Functionalization; Gene delivery; Nanomedicine; Nanotoxicology; Single wall carbon nanotubes; Targeted delivery

Indexed keywords

GREEN FLUORESCENT PROTEIN; PLASMID DNA; SINGLE WALLED NANOTUBE;

ARTICLE; CANCER CELL; CELL VIABILITY; COLORECTAL CANCER; CONTROLLED STUDY; CYTOTOXICITY; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL;

EID: 57349100449     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.1080/17435390802464994     Document Type: Article

References (11)

1. Cai D, Mataraza JM, Qin ZH, Huang ZP, Huang JY, Chiles TC, Carnahan D, Kempa K, Ren ZF. 2005. Highly efficient molecular delivery into mammalian cells using carbon nanotube spearing. Nature Methods 2(6):449-454.
2. Gao L, Nie L, Wang T, Qin Y, Guo Z, Yang D, Yan X. 2006. Carbon nanotube delivery of the GFP gene into mammalian cells. ChemBioChem 7(2):239-242.
3. Hampel S, Kunze D, Haase D, Kramer K, Rauschenbach M, Ritschel M, Leonhardt A, Thomas J, Oswald S, Hoffmann V, Buchner B. 2008. Carbon nanotubes filled with a chemotherapeutic agent: A nanocarrier mediates inhibition of tumor cell growth. Nanomedicine 3(2):175-182.
4. Hu H, Ni YC, Montana V, Haddon RC, Parpura V. 2004. Chemically functionalized carbon nanotubes as substrates for neuronal growth. Nano Lett 4(3):507-511.
5. Kam NWS, Jessop TC, Wender PA, Dai HJ. 2004. Nanotube molecular transporters: Internalization of carbon nanotubeprotein conjugates into mammalian cells. J Am Chem Soc 126(22):6850-6851.
6. li-Boucetta H, Al-Jamal KT, McCarthy D, Prato M, Bianco A, Kostarelos K. 2008. Multiwalled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics. Chem Commun (Camb) (4):459-461.
7. Lu Q, Moore JM, Huang G, Mount AS, Rao AM, Larcom LL, Ke PC. 2004. RNA polymer translocation with single-walled carbon nanotubes. Nano Lett 4(12):2473-2477.
8. Pantarotto D, Briand JP, Prato M, Bianco A. 2004a. Translocation of bioactive peptides across cell membranes by carbon nanotubes. Chem Commun 1:16-17.
9. Pantarotto D, Singh R, McCarthy D, Erhardt M, Briand JP, Prato M, Kostarelos K, Bianco A. 2004b. Functionalized carbon nanotubes for plasmid DNA gene delivery. Angew Chem Int Ed Engl 43(39):5242-5246.
10. Rojas-Chapana J, Troszczynska J, Firkowska I, Morsczeck C, Giersig M. 2005. Multi-walled carbon nanotubes for plasmid delivery into Escherichia coli cells. Lab Chip 5(5):536-539.
11. Wilson RW, Bloomfield VA. 1979. Counter-ion-induced condensation of deoxyribonucleic-acid - Light-scattering study. Biochemistry 18(11):2192-2196.