Microbial genome count in cerebrospinal fluid compared with clinical characteristics in pneumococcal and Haemophilus influenzae type b meningitis in children

Diagnostic Microbiology and Infectious Disease

Volumn 63, Issue 1, 2009, Pages 16-23

  Roine, Irmeli ^a   Saukkoriipi, Annika ^b   Leinonen, Maija ^b   Peltola, Heikki ^c  

^a UNIVERSIDAD DIEGO PORTALES   (Chile)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Bacterial meningitis; Genome count; Outcome; Real time PCR; Sequelae

Indexed keywords

ADOLESCENT; ARTICLE; BACTERIAL COUNT; BACTERIAL GENOME; CEREBROSPINAL FLUID ANALYSIS; CHILD; FEMALE; GENOME COUNT; HAEMOPHILUS INFLUENZAE TYPE B; HAEMOPHILUS MENINGITIS; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; NEUROLOGICAL COMPLICATION; NUCLEOTIDE SEQUENCE; PNEUMOCOCCAL MENINGITIS; PRESCHOOL CHILD; PRIORITY JOURNAL; PROGNOSIS; SCHOOL CHILD; STREPTOCOCCUS PNEUMONIAE;

ADOLESCENT; ANALYSIS OF VARIANCE; ANTI-BACTERIAL AGENTS; CHILD; CHILD, PRESCHOOL; DNA, BACTERIAL; FEMALE; GENOME, BACTERIAL; HAEMOPHILUS INFLUENZAE TYPE B; HEARING LOSS; HUMANS; INFANT; MALE; MENINGITIS, HAEMOPHILUS; MENINGITIS, PNEUMOCOCCAL; NERVOUS SYSTEM DISEASES; POLYMERASE CHAIN REACTION; PROGNOSIS; STATISTICS, NONPARAMETRIC; STREPTOCOCCUS PNEUMONIAE;

EID: 57349098712     PISSN: 07328893     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diagmicrobio.2008.09.005     Document Type: Article

References (22)

1. Bingen E., Lambert-Zechovsky N., Mariani-Kurkdijan P., Doit C., Aujard Y., Fournerie F., and Mathieu H. Bacterial counts in cerebrospinal fluid of children with meningitis. Eur. J. Clin. Microbiol. Infect. Dis. 9 (1990) 278-281
2. Carrol E.D., Guiver M., Nkhoma S., Mankhambo L.A., Marsh J., Balmer P., Banda D.L., Jeffers G., White S.A., Molyneux E.M., Molyneux M.E., Smyth R.L., and Hart C.A. High pneumococcal DNA loads are associated with mortality in Malawian children with invasive pneumococcal disease. Pediatr. Infect. Dis. J. 26 (2007) 416-422
3. Carvalho M.d.a.G., Tondella M.L., McGaustland K., Weidlich L., McGee L., Mayer L.W., Steigerwalt A., Whaley M., Facklam R.R., Fields B., Carlone G., Ades E.W., Dagan R., and Sampson J.S. Evaluation and improvement of real-time PCR assays targeting lytAplypsaA genes for detection of pneumococcal DNA. J. Clin. Microbiol. 45 (2007) 2460-2466
4. Cerquetti M., Cardines R., Ciofi Degli Atti M.L., Giufre M., Bella A., Sofia T., Mastrantonio P., and Slack M. Presence of multiple copies of capsulation b locus in invasive Haemophilus influenzae type vaccine failure. J. Infect. Dis. 192 (2005) 819-823
5. Corn P.G., Anders J., Takala A.K., Käyhty H., and Hoiseth S.K. Genes involved in Haemophilus influenzae type b capsule expression are frequently amplified. J. Infect. Dis. 167 (1993) 356-364
6. Falla T.J., Crook D.W.M., Brophy L.N., Maskell D., Kroll J.S., and Moxon E.R. PCR for capsular typing of Haemophilus influenzae. J. Clin. Microbiol. 32 (1994) 2382-2386
7. Feldman W.E. Concentrations of bacteria in cerebrospinal fluid of patients with bacterial meningitis. J. Pediatr. 88 (1976) 549-552
8. Feldman W.E. Relation of concentrations of bacteria and bacterial antigen in cerebrospinal fluid to prognosis in patients with bacterial meningitis. N. Engl. J. Med. 296 (1977) 433-435
9. Feldman W.E. Effect of prior antibiotic therapy on concentrations of bacteria in CSF. Am. J. Dis. Child 132 (1978) 672-674
10. Glascoe F.P., Byrne K.E., Ashford L.G., Johnson K.L., Chang B., and Strickland B. Accuracy of the Denver-II in developmental screening. Pediatrics 89 (1992) 1221-1225
11. Hackett S.J., Guiver M., Marsh J., Sills J.A., Thomson A.P., Kaczmarski E.B., and Hart C.A. Meningococcal bacterial DNA at presentation correlates with disease severity. Arch. Dis. Child. 86 (2002) 44-46
12. Kallio M.J., Kilpi T., Anttila M., and Peltola H. The effect of a recent previous visit to a physician on outcome after childhood bacterial meningitis. JAMA 272 10 (1994) 787-791
13. Kauc L. Determination of genome size of Haemophilus influenzae Sb: analysis of DNA restriction fragments. Acta Microbiol. Pol. 41 (1992) 13-24
14. Kilpi T., Anttila M., Kallio M.J., and Peltola H. Length of prediagnostic history related to the course and sequelae of childhood bacterial meningitis. Pediatr. Infect. Dis. J. 12 (1993) 184-188
15. La Scolea Jr. L.J., and Dryja D. Quantification of bacteria in cerebrospinal fluid and blood of children with meningitis and its diagnostic significance. J. Clin. Microbiol. 19 (1984) 187-190
16. Peltola H. Burden of meningitis and other severe bacterial infections of children in Africa: implications for prevention. Clin. Infect. Dis. 32 (2001) 64-75
17. Peltola H., Roine I., Fernández J., Zavala I., González Ayala S., González Mata A., Arbo A., Bologna R., Miño G., Goyo J., López E., Dourado de Andrade S., and Sarna S. Adjuvant glycerol and/or da prospective, randomized, double-blind, placebo-controlled trial. Clin. Infect. Dis. 45 (2007) 1277-1286
18. Rummel RJ (1976) Understanding correlation. E-pub Honolulu: Department of political science, University of Hawai. Available at: http://www.hawaii.edu/powerkills/UC.HTM. Cited 1 May 2007.
19. Saukkoriipi A., Palmu A., Kilpi T., and Leinonen M. Real-time quantitative PCR for the detection of Streptococcus pneumoniae in the middle ear fluid of children with acute otitis media. Mol. Cell. Probes 16 (2002) 385-390
20. Saukkoriipi A., Kaijalainen T., Kuisma L., Ojala A., and Leinonen M. Isolation of pneumococcal DNA from nasopharyngeal samples for real-time, quantitative PCR. Comparison of three methods. Mol. Diagn. 7 (2003) 9-15
21. van Haeften R., Palladino S., Kay I., Keil T., Heath C., and Waterer G.W. A quantitative LightCycler PCR to detect Streptococcus pneumoniae in blood and CSF. Diagn. Microbiol. Infect. Dis. 47 (2003) 407-414
22. Whatmore A.M., Efstratiou A., Pickerill A.P., Broughton K., Woodard G., Sturgeon D., George R., and Dowson C.G. Genetic relationship between clinical isolates of Streptococcus pneumoniaeStreptococcus oralis and Streptococcus mitis: characterization of "Atypical" pneumococci and organisms allied to S. mitis harboring S. pneumoniae virulence factor-encoding genes. Infect. Immun. 68 (2000) 1374-1382