Large-conductance K+ channel opener CGS7184 as a regulator of endothelial cell function

European Journal of Pharmacology

Volumn 602, Issue 1, 2009, Pages 105-111

  Wrzosek, Antoni ^a   Łukasiak, Agnieszka ^a,b   Gwóźdź, Pawel ^c   Malińska, Dominika ^a   Kozlovski, Valery I ^c,d   Szewczyk, Adam ^a   Chlopicki, Stefan ^c   Dołowy, Krzysztof ^b  

^a NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY   (Poland)

^b WARSAW UNIVERSITY OF LIFE SCIENCES   (Poland)

^c JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^d GRODNO STATE MEDICAL UNIVERSITY   (Belarus)

Author keywords

Channel openers; Endothelium; Mitochondria; Potassium channels

Indexed keywords

CGS 7184; ETHYL 1 [[(4 CHLOROPHENYL)AMINO]OXO] 2 HYDROXY 6 TRIFLUOROMETHYL 1H INDOLE 3 CARBOXYLATE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; AORTA FLOW; ARTICLE; BLOOD VESSEL TONE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DRUG MECHANISM; ENDOTHELIUM CELL; GUINEA PIG; ISOLATED HEART; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; VASCULAR RING; VASODILATATION;

ANIMALS; AORTA; CALCIUM; CELLS, CULTURED; CORONARY CIRCULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; ENDOTHELIUM, VASCULAR; GUINEA PIGS; HEART; HOMEOSTASIS; INDOLES; ION CHANNEL GATING; MITOCHONDRIA, HEART; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXYGEN CONSUMPTION; POTASSIUM CHANNELS; RATS; RATS, WISTAR; SPECTROMETRY, FLUORESCENCE; VASODILATOR AGENTS;

EID: 57349093388     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.10.066     Document Type: Article

References (42)

1. + current. J. Biol. Chem. 278 (2003) 46188-46194
2. + channel in renal artery endothelium in situ by nitric oxide and reactive oxygen species. Kidney Int. 64 (2003) 199-207
3. Busse R., and Mulsch A. Calcium-dependent nitric oxide synthesis in endothelial cytosol is mediated by calmodulin. FEBS Lett. 265 (1990) 133-136
4. Calderone V., Martelli A., Testai L., Martinotti E., and Breschi M.C. Functional contribution of the endothelial component to the vasorelaxing effect of resveratrol and NS 1619, activators of the large-conductance calcium-activated potassium channels. Naunyn-Schmiedeberg's Arch. Pharmacol. 375 (2007) 73-80
5. Chlopicki S., Lomnicka M., and Gryglewski R.J. Reversal of the postischaemic suppression of coronary function in perfused guinea pig heart by ischaemic preconditioning. J. Physiol. Pharmacol. 50 (1999) 605-615
6. + channels. Ann. N. Y. Acad. Sci. 868 (1999) 233-285
7. Davidson S.M., and Duchen M.R. Endothelial mitochondria: contributing to vascular function and disease. Circ. Res. 100 (2007) 1128-1141
8. + channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells. Biochem. Pharmacol. 65 (2003) 1827-1834
9. 2+ activated big conductance K channels in cultured human endothelial cells. Hypertension 50 (2007) 643-651
10. Edgell C.J., McDonald C.C., and Graham J.B. Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proc. Natl. Acad. Sci. U. S. A. 80 (1983) 3734-3737
11. Feletou M., and Vanhoutte P.M. Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture). Am. J. Physiol. Heart Circ. Physiol. 291 (2006) H985-1002
12. Fleming I., and Busse R. Signal transduction of eNOS activation. Cardiovasc. Res. 43 (1999) 532-541
13. + channels. Possible mechanism of cardioprotection. Circ. Res. 81 (1997) 1072-1082
14. Ghatta S., Nimmagadda D., Xu X., and O'Rourke S.T. Large-conductance, calcium-activated potassium channels: structural and functional implications. Pharmacol. Ther. 110 (2006) 103-116
15. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260 (1985) 3440-3450
16. Hu S., Fink C.A., Kim H.S., and Lappe R.W. Novel and potent BK channel openers: CGS 7181 and its analogs. Drug Dev. Res. 41 (1997) 10-21
17. Jaggar J.H., Porter V.A., Lederer W.J., and Nelson M.T. Calcium sparks in smooth muscle. Am. J. Physiol. Cell Physiol. 278 (2000) C235-256
18. Kicinska A., and Szewczyk A. Large-conductance potassium cation channel opener NS1619 inhibits cardiac mitochondria respiratory chain. Toxicol. Mech. Methods 14 (2004) 59-61
19. Ca channels independently of G protein-coupled receptor in human endothelial cells. Am. J. Physiol. Cell Physiol. 290 (2006) C1000-1008
20. +-channel opener NS1619 increases endothelial NO-synthesis involving p42/p44 MAP-kinase. Thromb. Haemost. 92 (2004) 1099-1107
21. Lawson K. Potassium channel openers as potential therapeutic weapons in ion channel disease. Kidney Int. 57 (2000) 838-845
22. Ledoux J., Werner M.E., Brayden J.E., and Nelson M.T. Calcium-activated potassium channels and the regulation of vascular tone. Physiology (Bethesda) 21 (2006) 69-78
23. Liu Y., Sato T., O'Rourke B., and Marban E. Mitochondrial ATP-dependent potassium channels: novel effectors of cardioprotection?. Circulation 97 (1998) 2463-2469
24. Logsdon N.J., Kang J., Togo J.A., Christian E.P., and Aiyar J. A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes. J. Biol. Chem. 272 (1997) 32723-32726
25. Luckhoff A., and Busse R. Calcium influx into endothelial cells and formation of endothelium-derived relaxing factor is controlled by the membrane potential. Pflugers Arch. 416 (1990) 305-311
26. 2+ refilling of the endoplasmic reticulum. J. Biol. Chem. 280 (2005) 12114-12122
27. Marty A. Ca-dependent K channels with large unitary conductance in chromaffin cell membranes. Nature 291 (1981) 497-500
28. Morano I. Tuning smooth muscle contraction by molecular motors. J. Mol. Med. 81 (2003) 481-487
29. Nardi A., Calderone V., and Olesen S.-P. Potassium channel openers: the case of BK channel activators. Lett. Drug Des. Discov. 3 (2006) 210-218
30. O'Rourke B. Mitochondrial ion channels. Annu. Rev. Physiol. 69 (2007) 19-49
31. Pallotta B.S. N-bromoacetamide removes a calcium-dependent component of channel opening from calcium-activated potassium channels in rat skeletal muscle. J. Gen. Physiol. 86 (1985) 601-611
32. + channels in cultured rat adrenal chromaffin cells. J. Physiol. 481 Pt 3 (1994) 555-570
33. Pries A.R., Secomb T.W., and Gaehtgens P. The endothelial surface layer. Pflugers Arch. 440 (2000) 653-666
34. 2+ sensitivity and block. J. Physiol. 455 (1992) 601-621
35. 2+-activated K channel of the BK-type in the inner mitochondrial membrane of a human glioma cell line. Biochem. Biophys. Res. Commun. 257 (1999) 549-554
36. + channel blockers inhibits acetylcholine-evoked nitric oxide release in rat superior mesenteric artery. Br. J. Pharmacol. 149 (2006) 560-572
37. Szewczyk A., and Wojtczak L. Mitochondria as a pharmacological target. Pharmacol. Rev. 54 (2002) 101-127
38. Wei A.D., Gutman G.A., Aldrich R., Chandy K.G., Grissmer S., and Wulff H. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. Pharmacol. Rev. 57 (2005) 463-472
39. Xia X.M., Zeng X., and Lingle C.J. Multiple regulatory sites in large-conductance calcium-activated potassium channels. Nature 418 (2002) 880-884
40. + channels in the cardiac inner mitochondrial membrane. Science 298 (2002) 1029-1033
41. Young R.C., Schumann R., and Zhang P. Intracellular calcium gradients in cultured human uterine smooth muscle: a functionally important subplasmalemmal space. Cell Calcium 29 (2001) 183-189
42. Ca channel by cGMP and cAMP kinase. J. Biol. Chem. 276 (2001) 43239-43245