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1
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36349020798
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and previous reports in this series
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B. M. Fraga, Nat. Prod. Rep. 2007, 24, 1350-1381, and previous reports in this series.
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Fraga, B.M.1
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2
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36348931495
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and previous reports in this series
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J. R. Hanson, Nat. Prod. Rep. 2007, 24, 1332-1341, and previous reports in this series.
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Nat. Prod. Rep
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Hanson, J.R.1
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3
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0344250161
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Isolation of 1a: a F. Bohlmann, C. Zdero, R. M. King, H. Robinson, Phytochemistry 1984, 23, 1187-1188;
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Isolation of 1a: a) F. Bohlmann, C. Zdero, R. M. King, H. Robinson, Phytochemistry 1984, 23, 1187-1188;
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-
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4
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0031690933
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of 1b: b A. Ortega, R. A. Toscano, E. Maldonado, Phytochemistry 1998, 49, 1085-1090;
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of 1b: b) A. Ortega, R. A. Toscano, E. Maldonado, Phytochemistry 1998, 49, 1085-1090;
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5
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1842859595
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of 2: c F. Bohlmann, C. Zdero, R. M. King, H. Robinson, Phytochemistry 1989, 28, 517-526.
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of 2: c) F. Bohlmann, C. Zdero, R. M. King, H. Robinson, Phytochemistry 1989, 28, 517-526.
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-
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7
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8644276334
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For recent examples involving compounds 1 or 2, see: a B. Siedle, A. J. García-Piñeres, R. Murillo, J. Schulte-Mönting, V. Castro, P. Rüngeler, C. A. Klaas, F. B. Da Costa, W. Kisiel, I. Merfort, J. Med. Chem. 2004, 47, 6042-6054;
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For recent examples involving compounds 1 or 2, see: a) B. Siedle, A. J. García-Piñeres, R. Murillo, J. Schulte-Mönting, V. Castro, P. Rüngeler, C. A. Klaas, F. B. Da Costa, W. Kisiel, I. Merfort, J. Med. Chem. 2004, 47, 6042-6054;
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8
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33644771102
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b) M. T. Lindenmeyer, A. Hrenn, C. Kern, V. Castro, R. Murillo, S. Müller, S. Laufer, J. Schulte-Mönting, B. Siedle, I. Merfort, Bioorg. Med. Chem. 2006, 14, 2487-2497;
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Lindenmeyer, M.T.1
Hrenn, A.2
Kern, C.3
Castro, V.4
Murillo, R.5
Müller, S.6
Laufer, S.7
Schulte-Mönting, J.8
Siedle, B.9
Merfort, I.10
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9
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33645675306
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c) S. Wagner, A. Hofmann, B. Siedle, L. Terfloth, I. Merfort, J. Gasteiger, J. Med. Chem. 2006, 49, 2241-2252.
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Wagner, S.1
Hofmann, A.2
Siedle, B.3
Terfloth, L.4
Merfort, I.5
Gasteiger, J.6
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10
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53849093470
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Y. Coquerel, M.-H. Filippini, D. Bensa, J. Rodriguez, Chem. Eur. J. 2008, 14, 3078-3092.
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Chem. Eur. J
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Coquerel, Y.1
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Bensa, D.3
Rodriguez, J.4
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11
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84890597202
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For recent monographs, see: a, Eds, J. Zhu, H. Bienaymé, Wiley-VCH, Weinheim
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For recent monographs, see: a) Multicomponent Reactions (Eds.: J. Zhu, H. Bienaymé), Wiley-VCH, Weinheim, 2005;
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Multicomponent Reactions
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84890766709
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Eds, L. F. Tietze, G. Brasche, K. M. Gericke, Wiley-VCH, Weinheim
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b) Domino Reactions in Organic Synthesis (Eds.: L. F. Tietze, G. Brasche, K. M. Gericke), Wiley-VCH, Weinheim, 2006.
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Domino Reactions in Organic Synthesis
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14
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45849122883
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For recent selected examples, see: a
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For recent selected examples, see: a) J. Isaacson, M. Loo, Y. Kobayashi, Org. Lett. 2008, 10, 1461-1463;
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16
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33751003264
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c) A. Dömling, B. Beck, U. Eichelberger, S. Sakamuri, S. Menon, Q.-Z. Chen, Y. Lu, L. A. Wessjohann, Angew. Chem. Int. Ed. 2006, 45, 7235-7239;
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Dömling, A.1
Beck, B.2
Eichelberger, U.3
Sakamuri, S.4
Menon, S.5
Chen, Q.-Z.6
Lu, Y.7
Wessjohann, L.A.8
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18
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34250701386
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CCDC-620411 (for 4) and -697454 [for 7 co-crystal of the two major diastereomers, contain the supplementary crystallographic data for this paper
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CCDC-620411 (for 4) and -697454 [for 7 (co-crystal of the two major diastereomers)] contain the supplementary crystallographic data for this paper. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data_request/cif.
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These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via
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19
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0015751251
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This unusual reactivity of NaBH4 with β-hydroxy esters has previously been observed, though not fully rationalized, see: a N. Finch, L. D. Vecchia, J. J. Fitt, R. Stephani, I. Vlattas, J. Org. Chem. 1973, 38, 4412-4424;
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4 with β-hydroxy esters has previously been observed, though not fully rationalized, see: a) N. Finch, L. D. Vecchia, J. J. Fitt, R. Stephani, I. Vlattas, J. Org. Chem. 1973, 38, 4412-4424;
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20
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0023777946
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b) K. C. Nicolaou, T. K. Chakraborty, Y. Ogawa, R. A. Daines, N. S. Simpkins, G. T. Furst, J. Am. Chem. Soc. 1988, 110, 4660-4672.
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Nicolaou, K.C.1
Chakraborty, T.K.2
Ogawa, Y.3
Daines, R.A.4
Simpkins, N.S.5
Furst, G.T.6
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21
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85004388152
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a) N. Hashimoto, T. Aoyama, T. Shiori, Chem. Pharm. Bull. 1981, 29, 1475-1478.
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Hashimoto, N.1
Aoyama, T.2
Shiori, T.3
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22
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34848822791
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For the mechanism, see: b
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For the mechanism, see: b) E. Kühnel, D. D. P. Laffan, G. C. Lloyd-Jones, T. Martínez del Campo, I. R. Shepperson, J. L. Slaughter, Angew. Chem. Int. Ed. 2007, 46, 7075-7078.
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Angew. Chem. Int. Ed
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Kühnel, E.1
Laffan, D.D.P.2
Lloyd-Jones, G.C.3
Martínez del Campo, T.4
Shepperson, I.R.5
Slaughter, J.L.6
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23
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57349134917
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Five chemical operations if the re-esterification of a part of the crude material of the MARDi cascade is included
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Five chemical operations if the re-esterification of a part of the crude material of the MARDi cascade is included.
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24
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33947468553
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The commercially available β-oxo ester 3 is derived from dimethyl adipate (Dieckmann cyclization), whereas the aldehyde 6 is obtained either from cyclohexene or adipaldehyde according to a one-pot protocol: E. D. Bergmann, A. Becker, J. Am. Chem. Soc. 1959, 81, 221-225, and references cited therein.
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The commercially available β-oxo ester 3 is derived from dimethyl adipate (Dieckmann cyclization), whereas the aldehyde 6 is obtained either from cyclohexene or adipaldehyde according to a one-pot protocol: E. D. Bergmann, A. Becker, J. Am. Chem. Soc. 1959, 81, 221-225, and references cited therein.
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