Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum

European Journal of Pharmacology

Volumn 602, Issue 1, 2009, Pages 1-7

  Miyamoto, Ichiko ^a   Liu, Jie ^a   Shimizu, Kuniyoshi ^a   Sato, Masao ^a   Kukita, Akiko ^b   Kukita, Toshio ^a   Kondo, Ryuichiro ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b SAGA UNIVERSITY   (Japan)

Author keywords

Bone protection; Ganoderic acid DM; Ganoderma lucidum; Osteoclast; Triterpenoid

Indexed keywords

ALCOHOL; CATHEPSIN K; GANODERIC ACID DM; GANODERMA LUCIDUM EXTRACT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MEMBRANE PROTEIN; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN C FOS; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NFATC1; TRITERPENE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE MARROW CELL; CELL FUSION; CHINESE MEDICINE; CONTROLLED STUDY; DENDRITIC CELL; DRUG ACTIVITY; DRUG INHIBITION; FEMALE; GANODERMA LUCIDUM; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; SPRAGUE DAWLEY RAT; TISSUE DIFFERENTIATION;

ANIMALS; BONE DENSITY; CELL DIFFERENTIATION; CELL FUSION; DENDRITIC CELLS; FEMALE; GENE EXPRESSION REGULATION; MALE; MEMBRANE PROTEINS; NFATC TRANSCRIPTION FACTORS; OSTEOCLASTS; OSTEOGENESIS; OVARIECTOMY; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-FOS; RANK LIGAND; RATS; RATS, SPRAGUE-DAWLEY; REISHI; TRITERPENES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 57249108190     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.11.005     Document Type: Article

References (25)

1. Anderson J.J., and Garner S.C. Phytoestrogens and bone. Baillieres Clin. Endocrinol. Metab. 12 (1998) 543-557
2. Bouker K.B., and Hilakivi-Clarke L. Genistein: does it prevent or promote breast cancer?. Environ. Health Perspect. 108 (2000) 701-708
3. Fioravanti L., Cappelletti V., Miodini P., Ronchi E., Brivio M., and Di Fronzo G. Genistein in the control of breast cancer cell growth: insights into the mechanism of action in vitro. Cancer Lett. 130 (1998) 143-152
4. Frost H.M., and Jee W.S. On the rat model of human osteopenias and osteoporoses. Bone Miner. 18 (1992) 227-236
5. Hidaka S., Okamoto Y., Yamada Y., Kon Y., and Kimura T. A Japanese herbal medicine, Chujo-to, has a beneficial effect on osteoporosis in rats. Phytother. Res. 13 (1999) 14-19
6. Kalu D.N. The ovariectomized rat model of postmenopausal bone loss. Bone Miner. 15 (1991) 175-191
7. Kim H.J., Bae Y.C., Park R.W., Choi S.W., Cho S.H., Choi Y.S., and Lee W.J. Bone-protecting effect of safflower seeds in ovariectomized rats. Calcif. Tissue Int. 71 (2002) 88-94
8. Kolta S., De Vernejoul M.C., Meneton P., Fechtenbaum J., and Roux C.J. Bone mineral measurements in mice: comparison of two devices. J. Clin. Densitom. 6 (2003) 251-258
9. Kukita A., Kukita T., Hata K., Kurisu K., and Kohashi O. Heat-treated osteoblastic cell (ROS17/2.8)-conditioned medium induces the formation of osteoclast-like cells. Bone Miner. 23 (1993) 113-127
10. Kukita A., Kukita T., Shin J.H., and Kohashi O. Induction of mononuclear precursor cells with osteoclastic phenotypes in a rat bone marrow culture system depleted of stromal cells. Biochem. Biophys. Res. Commun. 196 (1993) 1383-1389
11. Kukita T., Wada N., Kukita A., Kakimoto T., Sandra F., Toh K., Nagata K., Iijima T., Horiuchi M., Matsusaki H., Hieshima K., Yoshie O., and Nomiyama H. RANKL-induced DC-STAMP is essential for osteoclastogenesis. J. Exp. Med. 200 (2004) 941
12. MacDonald B.R., and Gowen M. Emerging therapies in osteoporosis. Best practice & research. Clin. Rheumatol. 15 (2001) 483-496
13. Martinez-Campos A., Amara J.F., and Dannies P.S. Antiestrogens are partial estrogen agonists for prolactin production in primary pituitary cultures. Mol. Cell. Endocrinol. 48 (1986) 127-133
14. Miodini P., Fioravanti L., Di Fronzo G., and Cappelletti V. The two phyto-oestrogens genistein and quercetin exert different effects on oestrogen receptor function. Br. J. Cancer 80 (1999) 1150-1155
15. Mosekilde L. Assessing bone quality-animal models in preclinical osteoporosis research. Bone 17 (1995) 343S-352S
16. Santell R.C., Chang Y.C., Nair M.G., and Helferich W.G. Dietary genistein exerts estrogenic effects upon the uterus, mammary gland and the hypothalamic/pituitary axis in rats. J. Nutr. 127 (1997) 263-269
17. Scheiber M.D., and Rebar R.W. Isoflavones and postmenopausal bone health: a viable alternative to estrogen therapy?. Menopause 6 (1999) 233-241
18. Tezuka K.I., Tezuka Y., Maejima A., Sato T., Nemoto K., Kamioka H., Hakeda Y., and Kumegawa M. Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts. J. Biol. Chem. 269 (1994) 1106-1109
19. Vignery A. Osteoclasts and giant cells: macrophage-macrophage fusion mechanism. Int. J. Exp. Pathol. 81 (2000) 291-304
20. Vignery A. Macrophage fusion: are somatic and cancer cells possible partners?. Trends Cell Biol. 15 (2005) 188-193
21. Watanabe T., Kukita T., Kukita A., Wada N., Toh K., Nagata K., Nomiyama H., and Iijima T. Direct stimulation of osteoclastogenesis by MIP-1alpha: evidence obtained from studies using RAW264 cell clone highly responsive to RANKL. J. Endocrinol. 180 (2004) 193-201
22. Wu J., Wang X., Chiba H., Higuchi M., Nakatani T., Ezaki O., Cui H., Yamada K., and Ishimi Y. Combined intervention of soy isoflavone and moderate exercise prevents body fat elevation and bone loss in ovariectomized mice. Metabolism 53 (2004) 942-948
23. Xu M., Dick I.M., Day R., Randall D., and Prince R.L. Effects of a herbal extract on the bone density, strength and markers of bone turnover of mature ovariectomized rats. Am. J. Chin. Med. 21 (2003) 87-101
24. Yagi M., Miyamoto T., Sawatani Y., Iwamoto K., Hosogane N., Fujita N., Morita K., Ninomiya K., Suzuki T., Miyamoto K., Oike Y., Takeya M., Toyama Y., and Suda T. DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells. J. Exp. Med. 202 (2005) 345-351
25. Zava D.T., and Duwe G. Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro. Nutr. Cancer 27 (1997) 31-40