Control of transdermal permeation of hydrocortisone acetate from hydrophilic and lipophilic formulations

AAPS PharmSciTech

Volumn 9, Issue 3, 2008, Pages 762-768

  Fini, Adamo ^a   Bergamante, Valentina ^a   Ceschel, Gian Carlo ^a   Ronchi, Celestino ^a   Moraes, Carlos Alberto Fonseca ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Gel and ointment; Hydrocortisone acetate; Microemulsions; Transdermal permeability

Indexed keywords

DIETHYLENE GLYCOL MONOETHYL ETHER; HYDROCORTISONE ACETATE; MACROGOL; PROPYLENE GLYCOL;

ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG PENETRATION; DRUG SOLUBILITY; DRUG TRANSPORT; EMULSION; EX VIVO STUDY; GEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; LIPOPHILICITY; MEMBRANE PERMEABILITY; MICROEMULSION; NONHUMAN; OINTMENT; SWINE; TOPICAL TREATMENT;

ADMINISTRATION, CUTANEOUS; ANIMALS; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; HYDROCORTISONE; LIPIDS; SKIN ABSORPTION; SWINE;

EID: 57149135651     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-008-9107-z     Document Type: Article

References (18)

1. A. F. Davis, R. J. Gyurik, J. Hadgraft, M. A. Pellet, and K. A. Walters. Formulation strategies for modulating skin permeation. In K. A. Walter (ed.), Dermatological and transdermal formulations, Dekker, New York, 2002, pp. 271-317.
2. S. A. Devos, and P. G. Van Der Valk. Relevance and reproducibility of patch-test reactions to corticosteroids. Contact Dermatitis. 44: 362-365 (2001).
3. X. Huang, H. Tanojo, J. Lenn, C. H. Deng, and L. Krochmal. A novel foam vehicle for delivery of topical corticosteroids. J. Am. Acad. Dermatol. 53: S26-S38 (2005).
4. E. Panconesi, and T. Lotti. Steroids versus nonsteroids in the treatment of cutaneous inflammation: Therapeutic modalities for office use. Arch. Dermatol. Res. 284: S37-S41 (1992).
5. I. Orienti, V. Zecchi, G. C. Ceschel, and A. Fini. Controlled release of hydrocortisone acetate from dermal bases. Eur. J. Drug Metab. Pharmacokinet. 3: 466-472 (1991).
6. R. H. Neubert, and A. Potzsch. Liberation of hydrocortisone acetate from different commercial formulations. Pharmazie. 59: 472-474 (2004).
7. H. Refai, and C. C. Müller-Goymann. The influence of dilution of topical semisolid preparations on hydrocortisone permeation through excised human stratum corneum. Eur. J. Pharm. Biopharm. 54: 143-150 (2002).
8. G. C. Ceschel, P. Maffei, S. Lombardi Borgia, and C. Ronchi. Design and evaluation of buccal adhesive hydrocortisone acetate (HCA) tablets. Drug Deliv. 8: 161-171 (2001).
9. R. Hajkova, P. Solich, J. Dvorak, and J. Sicha. Simultaneous determination of methylparaben, propylparaben, HCA and its degradation products in a topical cream by RP-HPLC. J. Pharm. Biomed. Anal. 32: 921-927 (2003).
10. E. Grippa, L. Santini, G. Castellano, M. T. Gatto, M. G. Leone, and L. Saso. Simultaneous determination of hydrocortisone, dexamethasone, indomethacin, phenylbutazone and oxyphenbutazone in equine serum by high-performance liquid chromatography. J. Chromatogr. B. Biomed. Sci. Appl. 738: 17-25 (2000).
11. Z. Hu, R. Prasad, R. Tawa, T. Konishi, M. Ishida, N. Shibata, and K. Takada. Diethyl ether fraction of Labrasol having a strong enhancing effect of gentamicin than Labrasol itself. Int. J. Pharm. 234: 223-235 (2002).
12. H. Kanazawa, T. Sunamoto, E. Ayano, Y. Matsushima, A. Kikuchi, and T. Okano. Temperature responsive chromatography using poly-(N-isopropylacrylamide) hydrogel-modified silica. Anal. Sci. 18: 45-48 (2000).
13. M. Kreilgaard. Influence of microemulsions on cutaneous drug delivery. Adv. Drug Deliv. Rev. 54 Suppl. 1:S77-S98 (2002).
14. A. Kogan, and N. Garti. Microemulsions as transdermal drug delivery vehicles. Adv. Coll. Interface Sci. 123-126: 369-385 (2006).
15. L. Lehmann, S. Keipert, and M. Gloor. Effects of microemulsions on the stratum corneum and hydrocortisone penetration. Eur. J. Pharm. Biopharm. 52: 129-136 (2001).
16. H. Refai, and C. C. Muller-Goymann. The influence of dilution of topical semisolid preparations on hydrocortisone permeation through excised human stratum corneum. Eur. J. Pharm. Biopharm. 54: 143-150 (2002).
17. M. Kreilgaard, E. J. Pedersen, and J. W. Jaroszewski. NMR characterisation and transdermal drug delivery potential of microemulsion systems. J. Control Rel. 69: 421-433 (2000).
18. J. Kemken, A. Ziegler, and B. W. Müller. Influence of supersaturation on the pharmacodynamic effect of bupranolol after dermal administration using microemulsions as vehicle. Pharm. Res. 9: 554-558 (1992).