Mitochondrial tRNAThr G15927A mutation may modulate the phenotypic manifestation of ototoxic 12S rRNA A1555G mutation in four Chinese families

Pharmacogenetics and Genomics

Volumn 18, Issue 12, 2008, Pages 1059-1070

  Wang, Xinjian ^a   Lu, Jianxin ^c   Zhu, Yi ^d   Yang, Aifen ^c   Yang, Li ^a   Li, Ronghua ^a   Chen, Bobei ^e   Qian, Yaping ^a   Tang, Xiaowen ^c   Wang, Jindan ^c   Zhang, Xue ^f   Guan, Min Xin ^a,b,c  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^d Department of Otolaryngology

^e WENZHOU MEDICAL UNIVERSITY   (China)

^f PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

Aminoglycoside; Chinese; Haplogroup; Hearing loss; Mitochondrial; Modifier; Mutation; Ototoxicity; Penetrance; Ribosomal rna; Trna; Variant

Indexed keywords

GENOMIC DNA; GENTAMICIN; GUANINE; MITOCHONDRIAL DNA; RIBOSOME RNA; RNA 12S; THREONINE; THREONINE TRANSFER RNA; ADENINE; AMINOGLYCOSIDE; CONNEXIN 26; GAP JUNCTION PROTEIN; MITOCHONDRIAL PROTEIN; RNA, RIBOSOMAL, 12S; TRANSFER RNA METHYLTRANSFERASE; TRMU PROTEIN, HUMAN; UNCLASSIFIED DRUG;

ARTICLE; CHINESE; CONTROLLED STUDY; DNA DETERMINATION; FEMALE; GENE EXPRESSION; GENE MUTATION; HEARING IMPAIRMENT; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; OTOTOXICITY; PENETRANCE; PHENOTYPE; PRIORITY JOURNAL; AMINOACYLATION; ASIAN; CELL LINE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CHINA; CONFORMATION; FAMILY; GENETICS; HEARING TEST; MITOCHONDRIAL GENOME; MITOCHONDRION; MOLECULAR GENETICS; MUTATION; PEDIGREE;

ADENINE; AMINOACYLATION; AMINOGLYCOSIDES; ASIAN CONTINENTAL ANCESTRY GROUP; BASE SEQUENCE; CELL LINE; CHINA; CONNEXINS; DEAFNESS; DNA MUTATIONAL ANALYSIS; FAMILY; FEMALE; GENOME, MITOCHONDRIAL; GUANINE; HEARING TESTS; HUMANS; MALE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEIC ACID CONFORMATION; PEDIGREE; PHENOTYPE; RNA, RIBOSOMAL; RNA, TRANSFER, THR; TRNA METHYLTRANSFERASES;

EID: 57149125444     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e3283131661     Document Type: Article

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