Increased arachidonic acid-induced thromboxane generation impairs skeletal muscle arteriolar dilation with genetic dyslipidemia

Microcirculation

Volumn 15, Issue 7, 2008, Pages 621-631

  Goodwill, Adam G ^a   Stapleton, Phoebe A ^a   James, Milinda E ^a   D'Audiffret, Alexandre C ^a,b   Frisbee, Jefferson C ^a  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Center for Interdisciplinary Research in Cardiovascular Sciences

Author keywords

Endothelium dependent dilation; Hypercholesterolemia; Mouse models of cardiovascular disease; Skeletal muscle microcirculation; Vascular reactivity

Indexed keywords

APOLIPOPROTEIN E; ARACHIDONIC ACID; LOW DENSITY LIPOPROTEIN RECEPTOR; PROSTACYCLIN; PROSTAGLANDIN H2; TEMPOL; THROMBOXANE A2;

ANIMAL EXPERIMENT; ARTERIOLE; ARTERY DILATATION; ARTICLE; BLOOD VESSEL REACTIVITY; C57BL 6 MOUSE; CARDIOVASCULAR DISEASE; CELL ISOLATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DYSLIPIDEMIA; FATTY ACID METABOLISM; FEMALE; GENE DELETION; GRACILIS MUSCLE; ICOSANOID METABOLISM; MALE; MOUSE; MUSCLE BLOOD VESSEL; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS;

ANIMALS; ANTIOXIDANTS; APOLIPOPROTEINS E; ARACHIDONIC ACID; ARTERIOLES; CYCLIC N-OXIDES; GENE KNOCKDOWN TECHNIQUES; HYPERCHOLESTEROLEMIA; MICE; MICE, MUTANT STRAINS; MUSCLE, SKELETAL; PROSTAGLANDIN H2; RECEPTORS, LDL; RECEPTORS, THROMBOXANE A2, PROSTAGLANDIN H2; SPIN LABELS; THROMBOXANE A2; VASODILATION;

MUS;

EID: 57149107813     PISSN: 10739688     EISSN: 15498719     Source Type: Journal    
DOI: 10.1080/10739680802308334     Document Type: Article

References (29)

1. American Heart Association Statistical Summary Sheets (2007) High Blood Cholesterol and Other Lipids. Online document at.
2. Bachschmid, M., Thurau, S., Zou, MH and Ullrich, V. (2003) Endothelial cell activation by endotoxin involves superoxide/NO-mediated nitration of prostacyclin synthase and thromboxane receptor stimulation. FASEB J, 17, pp. 914-916.
3. Bhatt, DL, Steg, PG, Ohman, EM, Hirsch, AT, Ikeda, Y., Mas, JL, Goto, S., Liau, CS, Richard, AJ, Rother, J., Wilson, PW and for the REACH Registry Investigators (2006) International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis. JAMA, 295, pp. 180-189.
4. 2 formation in the human circulation. Proc Natl Acad Sci U S A, 83, pp. 5861-5865.
5. de Jongh, S., Lilien, MR, op't Roodt, J, Stroes, ES, Bakker, HD and Kastelein, JJ. (2002) Early statin therapy restores endothelial function in children with familial hypercholesterolemia. J Am Coll Cardiol, 40, pp. 2117-2121.
6. Engler, MM, Engler, MB, Malloy, MJ, Chiu, EY, Schloetter, MC, Paul, SM, Stuehlinger, M., Lin, KY, Cooke, JP, Morrow, JD, Ridker, PM, Rifai, N., Miller, E., Witztum, JL and Mietus-Snyder, M. (2003) Antioxidant vitamins C and E improve endothelial function in children with hyperlipidemia: Endothelial Assessment of Risk from Lipids in Youth (EARLY) Trial. Circulation, 108, pp. 1059-1063.
7. Feletou, M. and Vanhoutte, PM. (2006) Endothelial dysfunction: A multifaceted disorder (The Wiggers Award Lecture). Am J Physiol Heart Circ Physiol, 291, pp. H985-H1002.
8. Frisbee, JC, Maier, KG, Falck, JR, Roman, RJ and Lombard, JH. (2002) Integration of hypoxic dilation signaling pathways for skeletal muscle resistance arteries. Am J Physiol Regul Integr Comp Physiol, 283, pp. R309-R319.
9. Godecke, A., Ziegler, M., Ding, Z. and Schrader, J. (2002) Endothelial dysfunction of coronary resistance vessels in apoE-/- mice involves NO but not prostacyclin-dependent mechanisms. Cardiovasc Res, 53, pp. 253-262.
10. Hansson, GK. (2005) Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med, 352, pp. 1685-1695.
11. Ishibashi, S., Brown, MS, Goldstein, JL, Gerard, RD, Hammer, RE and Herz, J. (1993) Hypercholesterolemia in low-density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest, 92, pp. 883-893.
12. Joyner, MJ and Dietz, NM. (1997) Nitric oxide and vasodilation in human limbs. J Appl Physiol, 83, pp. 1785-1796.
13. 2 and vasodilators during hypertension and elevated salt intake. Am J Physiol, 273, pp. H869-H877.
14. Nies, AS. (1986) Prostaglandins and the control of the circulation. Clin Pharmacol Ther, 39, pp. 481-488.
15. Pfister, SL. (2006) Aortic thromboxane receptor deficiency alters vascular reactivity in cholesterol-fed rabbits. Atherosclerosis, 189, pp. 358-363.
16. Pfister, SL and Campbell, WB. (1996) Contribution of arachidonic acid metabolites to reduced norepinephrine-induced contractions in hypercholesterolemic rabbit aortas. J Cardiovasc Pharmacol, 28, pp. 784-791.
17. Pfister, SL, Spitzbarth, N., Edgemond, W. and Campbell, WB. (1996) Vasorelaxation by an endothelium-derived metabolite of arachidonic acid. Am J Physiol, 270, pp. H1021-H1030.
18. Pfister, SL, Falck, JR and Campbell, WB. (1991) Enhanced synthesis of epoxyeicosatrienoic acids by cholesterol-fed rabbit aorta. Am J Physiol, 261, pp. H843-H852.
19. Piedrahita, JA, Zhang, SH, Hagaman, JR, Oliver, PM and Maeda, N. (1992) Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc Natl Acad Sci U S A., 89, pp. 4471-4475.
20. Salari, H., Braquet, P. and Borgeat, P. (1984) Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid, and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets. Prostaglandins Leukot Med, 13, pp. 53-60.
21. Srisawat, S., Phivthong-Ngam, L., Unchern, S., Chantharaksri, U., Govitrapong, P. and Sanvarinda, Y. (2003) Improvement of vascular function by chronic administration of a cyclo-oxygenase inhibitor in cholesterol-fed rabbits. Clin Exp Pharmacol Physiol, 30, pp. 405-412.
22. Stapleton, PA, Goodwill, AG, James, ME and Frisbee, JC. (2007) Altered mechanisms of endothelium-dependent dilation in skeletal muscle arterioles with genetic hypercholesterolemia. Am J Physiol Regul Integr Comp Physiol, 293, pp. R1110-R1119.
23. Stokes, KY, Cooper, D., Tailor, A. and Granger, DN. (2002) Hypercholesterolemia promotes inflammation and microvascular dysfunction: Role of nitric oxide and superoxide. Free Radic Biol Med, 33, pp. 1026-1036.
24. Wang, MH, Brand-Schieber, E., Zand, BA, Nguyen, X., Falck, JR, Balu, N. and Schwartzman, ML. (1998) Cytochrome P450-derived arachidonic acid metabolism in the rat kidney: Characterization of selective inhibitors. J Pharmacol Exp Ther, 284, pp. 966-973.
25. Wolfle, SE and de Wit, C. (2005) Intact endothelium-dependent dilation and conducted responses in resistance vessels of hypercholesterolemic mice in vivo. J Vasc Res, 42, pp. 475-482.
26. Zadelaar, S., Kleemann, R., Verschuren, L., de Vries-Van der Weij, J, van der Hoorn, J., Princen, HM and Kooistra, T. (2007) Mouse models for atherosclerosis and pharmaceutical modifiers. Arterioscler Thromb Vasc Biol, 27, pp. 1706-1721.
27. Zhang, DX, Gauthier, KM, Chawengsub, Y., Holmes, BB and Campbell, WB. (2005) Cyclo-oxygenase- and lipoxygenase-dependent relaxation to arachidonic acid in rabbit small mesenteric arteries. Am J Physiol Heart Circ Physiol, 288, pp. H302-H309.
28. Zou, MH, Cohen, R. and Ullrich, V. (2004) Peroxynitrite and vascular endothelial dysfunction in diabetes mellitus. Endothelium, 11, pp. 89-97.
29. Zou, MH, Leist, M. and Ullrich, V. (1999) Selective nitration of prostacyclin synthase and defective vasorelaxation in atherosclerotic bovine coronary arteries. Am J Pathol, 154, pp. 1359-1365.