Bone formation in a carbonate-substituted hydroxyapatite implant is inhibited by zoledronate: The importance of bioresorption to osteoconduction

Journal of Bone and Joint Surgery - Series B

Volumn 90, Issue 12, 2008, Pages 1635-1640

  Spence, G ^a   Phillips, S ^a   Campion, C ^a,b   Brooks, R ^a   Rushton, N ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ApaTech Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONIC ACID; HYDROXYAPATITE; ZOLEDRONIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE CONDUCTION; CERAMICS; CONTROLLED STUDY; FEMUR CONDYLE; INTERMETHOD COMPARISON; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SHEEP;

ANIMALS; BONE REGENERATION; BONE SUBSTITUTES; CARBONATES; CERAMICS; DURAPATITE; FEMORAL FRACTURES; FEMUR; FRACTURE HEALING; IMPLANTS, EXPERIMENTAL; MATERIALS TESTING; OSSEOINTEGRATION; OSTEOGENESIS; SHEEP;

EID: 57149101160     PISSN: 0301620X     EISSN: None     Source Type: Journal    
DOI: 10.1302/0301-620X.90B12.20931     Document Type: Article

References (24)

1. Bucholz RW. Clinical experience with bone graft substitutes. J Orthop Trauma 1987;1:260-2.
2. Klein CP, Driessen AA, de Groot K, van den Hooff A. Biodegradation behaviour of various calcium phosphate materials in bone tissue. J Biomed Mater Res 1983;17:769-84.
3. Schepers E, de Clerq M, Ducheyne P, Kempeneers R. Bioactive glass particulate material as a filler for bone lesions. J Oral Rehabil 1991;18:439-52.
4. Driessens FCM. The mineral in bone, dentin and tooth enamel. Bull Soc Chim Belg 1980;89:663-89.
5. Bigi A, Cojazzi G, Panzavolta S, et al. Chemical and structural characterization of the mineral phase from cortical and trabecular bone. J Inorg Biochem 1997;68:45-51.
6. Ellies LG, Carter JM, Natiella JR, Featherstone JD, Nelson DG. Quantitative analysis of early in vivo tissue response to synthetic apatite implants. J Biomed Mater Res 1988;22:137-48.
7. Patel N, Gibson IR, Hing KA, et al. The in vivo response of phase pure hydroxyapatite and carbonate substituted hydroxyapatite granules of varying size ranges. Key Eng Mat 2002;218:383-86.
8. Landi E, Celotti G, Logroscino G, Tampieri A. Carbonated hydroxyapatite as bone substitute. J Eur Cer Soc 2003;23:2931-7.
9. Hasegawa M, Doi Y, Uchida A. Cell-mediated bioresorption of sintered carbonate apatite in rabbits. J Bone Joint Surg [Br] 2003;85-B:142-7.
10. Patel N, Best SM, Gibson IR, Ke S, Hing KA, Bonfield W. Preparation and characterisation of hydroxyapatite and carbonate substituted hydroxyapatite granules. Key Eng Mat 2001;192:7-10.
11. Bohner M. Calcium orthophosphatase in medicine: from ceramics to calcium phosphate cements. Injury 2000;31(Suppl 4):37-47.
12. Spence GM, Patel N, Brooks RA, Bonfield W, Rushton N. Osteoblastic response to resorbed ceramic surfaces: the role of the osteoclast in osteoconduction. Key Eng Mat 2006;309:207-10.
13. Akao M, Aoki H, Kato K. Mechanical properties of sintered hydroxyapatite for prosthetic applications. J Mater Sci 1981;28:809.
14. Gibson IR, Bonfield W. Novel synthesis and characterization of an AB-type carbonate-substituted hydroxyapatite. J Biomed Mater Res 2002;59:697-708.
15. Minkin C. Bone acid phosphatase: tartrate-resistant acid phosphatase as a marker of osteoclast function. Calcif Tissue Int 1982;34:285-90.
16. Parfitt AM, Drezner MK, Glorieuz FH, et al. Bone histomorphometry: standardization of nomenclature, symbols, and units: report of the ASBMR Histomorphometry Nomenclature Committee. J Bone Miner Res 1987;2:595-610.
17. Delmas PD, Vergnaud P, Arlot ME, et al. The anabolic effect of human PTH (1-34) on bone formation is blunted when bone resorption is inhibited by the bisphosphonate tiludronate: is activated resorption a prerequisite for the in vivo effect of PTH on formation in a remodeling system? Bone 1995;16:603-10.
18. Schell H, Lienau J, Epari DR, et al. Osteoclastic activity begins early and increases over the course of bone healing. Bone 2006;38:547-54.
19. Spence GM, Patel N, Brooks RA, et al. Carbonate substituted hydroxyapatite, development and function of osteoclasts. Key Eng Mat 2006;309:133-6.
20. Moran EL, Fornasier TL, Bogoch TR. Pamidronate prevents bone loss associated with carrageenan arthritis by reducing resorptive activity but not recruitment of osteoclasts. J Orthop Res 2000;18:873-81.
21. Little DG, McDonald M, Bransford R, Godfrey CB, Amanat N. Manipulation of the anabolic and catabolic responses with Op-1 and zoledronic acid in a rat critical defect model. J Bone Miner Res 2005;20:2044-52.
22. Bobyn JD, Hacking SA, Krygier JJ, et al. Zoledronic acid causes enhancement of bone growth into porous implants. J Bone Joint Surg [Br] 2005;87-B:416-20.
23. Hock JM, Hummert J, Boyce R, Fonseca J, Raisz LG. Resorption is not essential for the stimulation of bone growth by human PTH 1-34 in rats in vivo. J Bone Miner Res 1989;4:449-58.
24. Davies JE, Hosseini MM. Histodynamics of endosseous wound healing. In: Davies JE, ed. Bone Engineering. Toronto: em squared, 2000:1-14.