Narcolepsy and other hypersomnias in children

Current Opinion in Pediatrics

Volumn 20, Issue 6, 2008, Pages 666-675

  Kothare, Sanjeev V ^a   Kaleyias, Joseph ^b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b University Hospital of Patras Rio   (Greece)

Author keywords

Cataplexy; Child; Hypersomnia; Idiopathic hypersomnia; Narcolepsy

Indexed keywords

AMPHETAMINE; CLOMIPRAMINE; FLUOXETINE; HLA ANTIGEN; IMIPRAMINE; METHYLPHENIDATE; MODAFINIL; OREXIN A; OXYBATE SODIUM;

ANOREXIA; ANXIETY; BEDTIME DOSAGE; CATAPLEXY; CEREBROSPINAL FLUID ANALYSIS; CLINICAL ASSESSMENT; CLINICAL FEATURE; DIAGNOSTIC TEST; ENURESIS; EVENING DOSAGE; HEADACHE; HLA TYPING; HUMAN; HYPERSOMNIA; HYPERTENSION; INSOMNIA; IRRITABILITY; LABORATORY TEST; NARCOLEPSY; NAUSEA; NIGHTMARE; PATHOGENESIS; PATIENT REFERRAL; POLYSOMNOGRAPHY; PRACTICE GUIDELINE; PRIORITY JOURNAL; RESPIRATION DEPRESSION; REVIEW; SEDATION; SIDE EFFECT; TACHYCARDIA; TASTE DISORDER; TIC; TREMOR; URINE RETENTION; WEIGHT GAIN; XEROSTOMIA;

CHILD; DISORDERS OF EXCESSIVE SOMNOLENCE; HUMANS; NARCOLEPSY;

EID: 57149093825     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOP.0b013e328316bd85     Document Type: Review

References (85)

1. American Academy of Sleep Medicine. International classification of sleep disorders. 2nd ed. In: Diagnostic and coding manual. Westchester, Illinois: American Academy of Sleep Medicine; 2005.
2. Kotagal S, Pianosi P. Sleep disorders in children and adolescents. BMJ 2006; 332:828-832.
3. Léger D, Poursain B, Neubauer D, Uchiyama M. An international survey of sleeping problems in the general population. Curr Med Res Opin 2008; 24:307-317. This international omnibus survey investigated the prevalence and characteristics of sleep problems, as well as strategies for resolving sleep problems, in the general population of the United States, France, Germany, Italy, Spain, the UK, and Japan.
4. Billiard M, Alperovitch A, Perot C, Jammes A. Excessive daytime somnolence in young men: prevalence and contributing factors. Sleep 1987; 10:297-305.
5. Givan DC. The sleepy child. Pediatr Clin North Am 2004; 51:15-31.
6. Mindell JA, Durand VM. Treatment of childhood sleep disorders: generalization across disorders and effects on family members. J Pediatr Psychol 1993; 18:731-750.
7. Blunden S, Lushington K, Lorenzen B, et al. Are sleep problems underrecognized in general practice? Arch Dis Child 2004; 89:708-712.
8. Saarenpää-Heikkilä O, Laippala P, Koivikko M. Subjective sleepiness in children. Farm Pract 2000; 17:129-133.
9. Drake C, Nickel C, Burduvali E, et al. The pediatric daytime sleepiness scale (PDSS): sleep habits and school outcomes in middle-school children. Sleep 2003; 26:455-458.
10. Hansen M, Janssen I, Schiff A, et al. The impact of school daily schedule on adolescent sleep. Pediatrics 2005; 115:1555-1561.
11. Kothare SV, Kaleyias J. The clinical and laboratory assessment of the sleepy child. Semin Pediatr Neurol 2008; 15:61-69. A comprehensive review of the clinical and laboratory assessment of the sleepy child.
12. Blunden S, Hoban TF, Chervin RD. Sleepiness in children. Sleep Med Clin 2006; 1:105-118.
13. Carskadon MA, Dement WC. Normal human sleep: an overview. In: Kryger MH, Roth T, Dement WC, editors. Principles and practice of sleep medicine. 4th ed. Philadelphia: Elsevier; 2005. pp. 13-23.
14. Maltzer LJ, Mindell JA. Sleep and sleep disorders in children and adolescents. Psychiatr Clin North Am 2006; 29:1059-1076.
15. Kotagal S. Sleep disorders in childhood. Neurol Clin 2003; 21:961-981.
16. Ivanenko A, Crabtree VM, Gozal D. Sleep In children with psychiatric disorders. Pediatr Clin North Am 2004; 51:51-68.
17. Liu X, Buysse DJ, Gentzler AL, et al. Insomnia and hypersomnia associated with depressive phenomenology and comorbidity in childhood depression. Sleep 2007; 30:83-90.
18. LeBourgeois MK, Avis K, Mixon M, et al. Snoring, sleep quality, and sleepiness across attention-deficit/hyperactivity disorder subtypes. Sleep 2004; 27:520-525.
19. Cortese S, Konofal E, Yateman N, et al. Sleep and alertness in children with attention-deficit/hyperactivity disorder: a systematic review of the literature. Sleep 2006; 29:504-511.
20. Wise MS, Lynch J. Narcolepsy in children. Semin Pediatr Neurol 2001; 8:198-206.
21. Shur-Fen Gau S. Prevalence of sleep problems and their association with inattention/hyperactivity among children aged 6-15 in Taiwan. J Sleep Res 2006; 15:403-414.
22. Martin SK, Eastman Cl. Sleep logs of young adults with self-selected sleep times predict the dim light melatonin onset. Chronobiol Int 2002; 19:695-707.
23. Hoddes E, Zarcone V, Smythe H, et al. Quantification of sleepiness: a new approach. Psychophysiology 1973; 10:431-436.
24. Johns MW. A new method for measuring daytime sleepiness: the Epworth Sleepiness Scale. Sleep 1991; 14:540-545.
25. Perez-Chada D, Perez-Lloret S, Videla AJ, et al. Sleep disordered breathing and daytime sleepiness are associated with poor academic performance in teenagers. A study using the pediatric daytime sleepiness scale (PDSS). Sleep 2007; 30:1698-1703.
26. Ivanenko A, Crabtree VM, Obrien LM, Gozal O. Sleep complaints and psychiatric symptoms in children evaluated at a pediatric mental health clinic. J Clin Sleep Med 2006; 2:42-48.
27. Chervin RD, Hedger K, Dillon JE, Pituch KJ. Pediatric sleep questionnaire (PSO): validity and reliability of scales for sleep-disordered breathing, snoring, sleepiness, and behavioral problems. Sleep Med 2000; 1:21-32.
28. Morgenthaler T, Alessi C, Friedman L, et al., Standards of Practice Committee; American Academy of Sleep Medicine. Practice Parameters for the use of actigraphy in the assessment of sleep and sleep disorders: An update for 2007. Sleep 2007; 30:519-529.
29. Kushida CA, Littner MR, Morgenthaler T, et al. Practice parameters for the indications for polysomnography and related procedures: an update for 2005. Sleep 2005; 28:499-521.
30. Littner MR, Kushida C, Wise M, et al., Standards of Practice Committee of the American Academy of Sleep Medicine. Practice parameters for clinical use of the multiple sleep latency test and the maintenance of wakefulness test. Sleep 2005; 28:113-121.
31. Mitler MM, Doghramji K, Shapiro C. The maintenance of wakefulness test. Normative data by age. J Psychosom Res 2000; 49:363-365.
32. Mignot E, Young T, Lin L, Finn L Nocturnal sleep and daytime sleepiness in normal subjects with HLA-DQB1*0602. Sleep 1999; 22:347-352.
33. Kanbayashi T, Inoue Y, Chiba S, et al. CSF hypocretin-1 (orexin-A) concentrations in narcolepsy with and without cataplexy and idiopathic hypersomnia. J Sleep Res 2002; 11:91-93.
34. Nishino S. Clinical and neurobiological aspects of narcolepsy. Sleep Med 2007; 8:373-399. In this review, the clinical, pathophysiological, and pharmacological aspects of narcolepsy are discussed.
35. Guilleminault C, Zvoniska V, Tantrakul V, Kim JH. Advances in narcolepsy • syndrome and challenges in the pediatric population. Sleep Med Clin 2007; 2:397-404. Advances and challenges in pediatric narcolepsy are presented in the study.
36. Wise MS, Arand DL, Auger R, et al., American Academy of Sleep Medicine. Treatment of narcolepsy and other hypersomnias of central origin. Sleep 2007; 30:1712-1727. An excellent comprehensive review of the current knowledge about treatment of narcolepsy and other hypersomnias of central origin.
37. Vankova J, Stepanova I, Jech R, et al. Sleep disturbances and hypocretin deficiency in Niemann-Pick disease type C. Sleep 2003; 26:427-430.
38. Marcus CL, Trescher WH, Halbower AC, Lutz J. Secondary narcolepsy in children with brain tumors. Sleep 2002; 25:435-439.
39. Watson NF, Doherty MJ, Zunt JR. Secondary narcolepsy following neurocysticercosis infection. J Clin Sleep Med 2005; 1:41-42.
40. Tobias ES, Tolmie JL, Stephenson JB. Cataplexy in the Prader-Willi syndrome. Arch Dis Child 2002; 87:170.
41. Wagner MH, Berry RB. An obese female with Prader-Willi syndrome and daytime sleepiness. J Clin Sleep Med 2007; 3:645-647.
42. Smit LS, Lammers GJ, Catsman-Berrevoets CE. Cataplexy leading to the diagnosis of Niemann-Pick disease type C. Pediatr Neurol 2006; 35:82-84.
43. Ohayon MM, Ferini-Strambi L, Plazzi G, et al. How age influences the expression of narcolepsy. J Psychosom Res 2005; 59:399-405.
44. Vendrame M, Havaligi N, Matadeen-Ali C, et al. Narcolepsy in children: a single-center clinical experience. Pediatr Neurol 2008; 38:314-320. A retrospective review of 125 children referred in 1 year for hypersomnia revealed 20 patients (16%) with narcolepsy. Eighty-five percent of children with narcolepsy had SDB on polysomnography. Treatment with modafinil and sodium oxybate provided optimal control of daytime sleepiness.
45. Bokkala S, Napalinga K, Pinninti N, et al. Correlates of periodic limb movements of sleep in the pediatric population. Pediatr Neurol 2008; 39:33-39.
46. Hayes D Jr. Narcolepsy with Cataplexy in early childhood. Clin Pediatr (Phila) 2006; 45:361-363.
47. Peterson PC, Husain AM. Pediatric narcolepsy. Brain Dev 2008 [Epub ahead of print] A detailed review of the epidemiology, pathophysiology, and management of narcolepsy in children is presented.
48. Benca RM. Narcolepsy and excessive daytime sleepiness: diagnostic considerations, epidemiology, and comorbidities. Clin Psychiatry 2007; 68:S5-88. This comprehensive review on narcolepsy highlighted the association of EDS with a broad range of medical, sleep, and psychiatric disorders and the importance of accurate diagnosis for optimal treatment response.
49. Wise SW. Narcolepsy and other disorders of excessive sleepiness. Med Clin North Am 2004; 88:597-610.
50. Serra L, Montagna P, Mignot E, et al. Cataplexy features in childhood narcolepsy. Mov Disord 2008; 23:858-865. This study systematically used structured clinical assessments and video recordings (49 episodes in eight cases) to evaluate Cataplexy in 23 patients diagnosed before the age of 18 years.
51. Guilleminault C, Pelayo R. Narcolepsy in children: a practical guide to its diagnosis, treatment and follow-up. Paediatr Drugs 2000; 2:1-9.
52. Dahl RE, Holttum J, Trubnick L. A clinical picture of child and adolescent narcolepsy. J Am Acad Child Adolesc Psychiatry 1994; 33:834-841.
53. Dauvilliers Y, Rompre S, Gagnon JF, et al. REM sleep characteristics in narcolepsy and REM sleep behavior disorder. Sleep 2007; 30:844-849. Sixteen patients with narcolepsy and cataplexy matched for age and sex with 16 patients with 'idiopathic' RBD and with 16 normal controls were studied in order to assess the presence of polysomnographic characteristics of REM sleep behavior disorder (RBD) in narcolepsy in this study and quantify REM sleep parameters in patients with narcolepsy, in patients with 'idiopathic' RBD, and in normal controls.
54. Gagnon JF, Postuma RB, Mazza S, et al. Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases. Lancet Neurol 2006; 5:424-432.
55. Nevsimalova S, Prihodova I, Kemlink D, et al. REM behavior disorder (RBD) can be one of the first symptoms of childhood narcolepsy. Sleep Med 2007; 8:784-786.
56. Fortuyn HA, Swinkels S, Buitelaar J, et al. High prevalence of eating disorders in narcolepsy with cataplexy: a case-control study. Sleep 2008; 31:335-341.
57. Dahmen N, Kasten M, Wieczorek S, et al. Increased frequency of migraine in narcoleptic patients: a confirmatory study. Cephalalgia 2003; 23:14-19.
58. Aldrich MS. Narcolepsy. Neurology 1992; 42:34-43.
59. Black JE, Brooks SN, Nishino S. Narcolepsy and syndromes of primary excessive daytime somnolence. Semin Neurol 2004; 24:271-282.
60. Chemelli RM, Willie JT, Sinton CM, et al. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 1999; 98:437-451.
61. Peyron C, Faraco J, Rogers W, et al. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med 2000; 6:991-997.
62. Buskova J, Vaneckova M, Sonka K, et al. Reduced hypothalamic gray matter in narcolepsy with cataplexy. Neuro Endocrinol Lett 2006; 27:769-772.
63. Silber MH, Rye DB. Solving the mysteries of narcolepsy: the hypocretin story. Neurology 2001; 56:1616-1618.
64. Taheri S, Zeitzer JM, Mignot E. The role of hypocretins (orexins) in sleep regulation and narcolepsy. Annu Rev Neurosci 2002; 25:283-313.
65. Arand D, Bonnet M, Hurwitz T, et al. The clinical use of the MSLT and MWT. Sleep 2005; 28:123-144.
66. Kotagal S, Hartse KM, Walsh JK. Characteristics of narcolepsy in preteenaged children. Pediatrics 1990; 85:205-209.
67. Singh M, Drake CL, Roth T. The prevalence of multiple sleep-onset REM periods in a population-based sample. Sleep 2006; 29:890-895.
68. Aldrich MS, Chervin RD, Malow BA. Value of the multiple sleep latency test (MSLT) for the diagnosis of narcolepsy. Sleep 1997; 20:620-629.
69. Nishino S, Ripley B, Overeem S, et al. Low cerebrospinal fluid hypocretin (orexin) and altered energy homeostasis in human narcolepsy. Ann Neurol 2001; 50:381-388.
70. Krahn LE, Pankratz VS, Oliver L, et al. Hypocretin (orexin) levels in cerebrospinal fluid of patients with narcolepsy: Relationship to cataplexy and HLA DQB1*0602 status. Sleep 2002; 25:733-736.
71. Anderson KN, Pilsworth S, Sharpies LD, et al. Idiopathic hypersomnia: a study of 77 cases. Sleep 2007; 30:1274-1281. A retrospective study of the clinical and polysomnographic characteristics of 77 patients with idiopathic hypersomnia was performed. Comparison with a similar group of patients with narcolepsy was performed.
72. Bassetti C, Aldrich MS. Idiopathic hypersomnia. A series of 42 patients. Brain 1997; 120:1423-1435.
73. Billiard M, Dauvilliers Y. Idiopathic hypersomnia. Sleep Med Rev 2001; 5:349-358.
74. Bruck D, Parkes JD. A comparison of idiopathic hypersomnia and narcolepsy-cataplexy using self report measures and sleep diary data. J Neurol Neurosurg Psychiatry 1996; 60:576-578.
75. Arnulf I, Lin L, Gadoth N, et al. Kleine-Levin syndrome: a systematic study of 108 patients. Ann Neurol 2008; 63:482-493. A detailed evaluation of 108 patients with Kleine-Levin syndrome, 79 parent pairs, and 108 matched controls. Novel predisposing factors were identified including increased birth and developmental problems. HLA typing was unremarkable.
76. Arnulf I, Zeitzer JM, File J, et al. Kleine-Levin syndrome: a systematic review of 186 cases in the literature. Brain 2005; 128:2763-2776.
77. Lamarche LJ, Driver HS, Wiebe S, et al. Nocturnal sleep, daytime sleepiness, and napping among women with significant emotional/behavioral premenstrual symptoms. J Sleep Res 2007; 16: 262-268.
78. Manber R, Bootzin RR. Sleep and the menstrual cycle. Health Psychol 1997; 16:209-214.
79. Manni R, Tartara A. Evaluation of sleepiness in epilepsy. Clin Neurophysiol 2000; 111:S111-S114.
80. Kothare SV, Kaleyias J. The adverse effects of antiepileptic drugs in children. Expert Opin Drug Saf 2007; 6:251-265.
81. Morgenthaler TI, Kapur VK, Brown T, et al., Standards of Practice Committee of the American Academy of Sleep Medicine. Practice parameters for the treatment of narcolepsy and other hypersomnias of central origin. Sleep 2007; 30:1705-1711. These practice parameters pertain to the treatment of hypersomnias of central origin.
82. Rogers AE, Aldrich MS, Lin X. A comparison of three different sleep schedules for reducing daytime sleepiness in narcolepsy. Sleep 2001 ; 24:385-391.
83. Thorpy M. Therapeutic advances in narcolepsy. Sleep Med 2007; 8:427-440. A review of the fascinating therapeutic advances in narcolepsy.
84. Robinson DM, Keating GM. Sodium oxybate: a review of its use in the management of narcolepsy. CNS Drugs 2007; 21:337-354. A review of the use of sodium oxybate in the treatment of narcolepsy.
85. Murali H, Kotagal S. Off-label treatment of severe childhood narcolepsy - cataplexy with sodium oxybate. Sleep 2006; 29:1025-1029.