In-line monitoring of reactive crystallization process based on ATR-FTIR and Raman spectroscopy

Journal of Chemometrics

Volumn 22, Issue 11-12, 2008, Pages 644-652

  Alatalo, Hannu ^a   Kohonen, Jarno ^a   Qu, Haiyan ^a   Hatakka, Henry ^a   Reinikainen, Satu Pia ^a   Louhi Kultanen, Marjatta ^a   Kallas, Juha ^a  

^a LAPPEENRANTA UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

ATR FTIR; L glutamic acid; PLS; Precipitation; Raman

Indexed keywords

AMINO ACIDS; FOURIER TRANSFORM INFRARED SPECTROSCOPY; RAMAN SPECTROSCOPY; SODIUM SULFATE; SULFUR COMPOUNDS; SUPERSATURATION; THERMODYNAMICS; VOLTAGE MEASUREMENT;

ATTENUATED TOTAL REFLECTANCE; ATTENUATED TOTAL REFLECTANCE-FOURIER TRANSFORMED INFRARED; CRYSTALLIZATION PROCESS; FOURIER; IN-LINE MONITORING; INFRARED AND RAMAN SPECTROSCOPY; L-GLUTAMIC ACIDS; PLS; RAMAN; Β-FORM;

PRECIPITATION (CHEMICAL);

EID: 57149093028     PISSN: 08869383     EISSN: 1099128X     Source Type: Journal    
DOI: 10.1002/cem.1161     Document Type: Conference Paper

References (30)

1. Harjo B, Ng KM. Development of amino acid crystallization process: L-glutamic acid. Ind. Eng. Chem. Res. 2007; 46: 2814-2822.
2. Hirokawa S. A new modification of L-glutamic acid and its crystal structure. Acta Cryst. 1955; 8: 637-641.
3. Kitamura M. Controlling factor of polymorphism in crystallization process. J. Cryst. Growth 2002; 237-239: 2205-2214.
4. Roelands CPM, ter Horst JH, Kramer HJM, Jansens PJ. Precipitation mechanism of stable and metastable polymorphs of L-glutamic acid. AIChE J. 2007; 53: 354-362.
5. Kitamura M, Ishizu T. Growth kinetics and morphological change of polymorphs of L-glutamic acid. J. Cryst. Growth 2000; 209: 138-145.
6. Davey RJ, Blagden N, Potts GD, Docherty R. Polymorphism in molecular crystals: stabilization of a metastable form by conformational mimicry. J. Am. Chem. Soc. 1997; 119: 1767-1772.
7. Cashell C, Corcoran D, Hodnett BK. Effect of amino acid additives on the crystallization of L-glutamic acid. Cryst. Growth Des. 2005; 5: 593-597.
8. Garti N, Zour H. The effect of surfactants on the crystallization and polymorphic transformation of glutamic acid. J. Cryst. Growth 1997; 172: 486-498.
9. Dunuwila DD, Carroll LB, Berglund KA. An investigation of the application of attenuated total reflection infrared spectroscopy for measurement of solubility and supersaturation of aqueous citric acid solutions. J. Cryst. Growth 1994; 137: 561-568.
10. Lewiner F, Klein JP, Puel F, Fevotte G. On-line ATR-FTIR measurement of supersaturation during solution crystallization processes. Calibration and application on three solute/solvent systems. Chem. Eng. Sci. 2001; 56: 2069-2084.
11. Grön H, Borissova A, Roberts KJ. In-process ATR-FTIR spectroscopy for closed-loop supersaturation control of a batch crystallizer producing monosodium glutamate crystals of defined size. Ind. Eng. Chem. Res. 2003; 42: 198-206.
12. Qu H, Pöllänen K, Louhi-Kultanen M, Kilpiö T, Oinas P, Kallas J. Batch cooling crystallization study based on in-line measurement of supersaturation and crystal size distribution. J. Cryst. Growth 2005; 275: e1857-e1862.
13. Starbuck C, Spartalis A, Wai L, Wang J, Fernandez P, Lindemann CM, Zhou GX, Ge Z. Process optimization of a complex pharmaceutical polymorphic system via in situ Raman spectroscopy. Cryst. Growth Des. 2002; 2: 515-522.
14. Qu H, Louhi-Kultanen M, Rantanen J, Kallas J. Solvent-mediated phase transformation kinetics of an anhydrate/hydrate system. Cryst. Growth Des 2006; 6: 2053-2060.
15. Hu Y, Liang JK, Myerson AS, Taylor LS. Crystallization monitoring by Raman spectroscopy: simultaneous measurement of desupersaturation profile and polymorphic form in flufenamic acid systems. Ind. Eng. Chem. Res. 2005; 44: 1233-1240.
16. Ono T, ter Horst JH, Jansens PJ. Quantitative measurement of the polymorphic transformation of L-glutamic acid using in-situ Raman spectroscopy. Cryst. Growth Des. 2004; 4: 465-469.
17. Schöll J, Bonalumi D, Vicum L, Mazzotti M, Muller M. In situ monitoring and modeling of the solvent-mediated polymorphic transformation of L-glutamic acid. Cryst. Growth Des. 2006; 6: 881-891.
18. Caillet A, Puel F, Fevotte G. In-line monitoring of partial and overall solid concentration during solvent-mediated phase transformation using Raman spectroscopy. Int. J. Pharm. 2006; 307: 201-208.
19. Fevotte G. In situ Raman spectroscopy for in-line control of pharmaceutical crystallization and solids elaboration processes: a review. Trans IChemE, part A, Chem. Eng. Des. 2007; 85(A7): 906-920.
20. Borissova A, Jammoal Y, Javed KH, Lai X, Mahmud T, Penchev R, Roberts KJ. Modelling the precipitation of L-glutamic acid via acidification of monosodium glutamate. Cryst. Growth Des. 2005; 5(3): 845-854.
21. Schöll J, Vicum L, Müller M, Mazzotti M. Precipitation of glutamic acid: determination of nucleation kinetics. Chem. Eng. Technol. 2006; 29(2): 257-264.
22. Partanen JI, Juusola PM, Minkkinen PO. Redetermination of the thermodynamic values of the first and second dissociation constants of glutamic acid in aqueous solutions at 298,15 K. Acta Chem. Scand. 1998; 52: 198-206.
23. Pitzer KS, Rabindra NR, Silvester LF. Thermodynamics of electrolytes. 7. Sulphuric acid. J. Am. Chem. Soc. 1977; 4930-4936.
24. Bates RG, Guggenheim EA. Report on the standardization of pH and related terminology. Pure Appl. Chem. 1960; 1: 163.
25. Pöllänen K, Häkkinen A, Reinikainen S-P, Rantanen J, Minkkinen P. Dynamic PCA based approach on MSPC charts in nucleation prediction in batch cooling crystallization processes. Chemometr. Intell. Lab. Syst. 2006; 84: 126-133.
26. Qu H, Kohonen J, Louhi-Kultanen M, Reinikainen S-P, Kallas J. Crystallization mechanism of anhydrate/hydrate from aqueous solution: from intermolecular interaction to nucleation and growth of the crystals. Ind. Eng. Chem. Res. (submitted).
27. Martens H, Martens M. Multivariate Analysis of Quality: An Introduction. John Wiley & Sons: England, 2001; 111-120.
28. MacGregor JF, Kourti T. Statistical process control of multivariate processes. Control Eng. Pract. 1995; 3(3): 403-414.
29. Rovner SL. Hold that though. Chem. Eng. News 2007; 85(36): 13-20.
30. Rovner SL. Molecules for memory. Chem. Eng. News 2007; 85(36): 22-24.