Genetic variations in UDP-glucuronosyl transferase 2B17: Implications for testosterone excretion profiling and doping control programs

Clinical Chemistry

Volumn 54, Issue 12, 2008, Pages 1945-1947

  Starcevic, Borislav ^a   Butch, Anthony W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITESTOSTERONE; GLUCURONOSYLTRANSFERASE; TESTOSTERONE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 2B17;

DOPING; EXCRETION; FEMALE; GAS CHROMATOGRAPHY; GENE; GENE DELETION; GENETIC ANALYSIS; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; MALE; MASS SPECTROMETRY; SENSITIVITY AND SPECIFICITY; SHORT SURVEY; UGT2B17 GENE;

ANABOLIC AGENTS; CONTINENTAL POPULATION GROUPS; DOPING IN SPORTS; FEMALE; GLUCURONOSYLTRANSFERASE; HUMANS; MALE; POLYMORPHISM, GENETIC; SUBSTANCE ABUSE DETECTION; TESTOSTERONE; TESTOSTERONE CONGENERS;

EID: 57149086729     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2008.110106     Document Type: Short Survey

References (5)

1. Jakobsson J, Ekstrom L, Inotsume N, Garle M, Lorentzon M, Ohlsson C, et al. Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism. J Clin Endocrinol Metab 2006;91:687-93.
2. Schulze JJ, Lundmark J, Garle M, Skilving I, Ekstrom L, Rane A. Doping test results dependent on genotype of UGT2B17, the major enzyme for testosterone glucuronidation. J Clin Endocrinol Metab 2008;93:2500-6.
3. Dehennin L. Detection of simultaneous self-administration of testosterone and epitestosterone in healthy men. Clin Chem 1994;40:106-9.
4. Aguilera R, Hatton CK, Catlin DH. Detection of epitestosterone doping by isotope ratio mass spectrometry. Clin Chem 2002;48:629-36.
5. Sottas PE, Saudan C, Schweizer C, Baume N, Mangin P, Saugy M. From population- to subject-based limits of T/E ratio to detect testosterone abuse in elite sports. Forensic Science (Wash DC) Int 2008;174:166-72.