Evaluation of the Safety and Efficacy of Sildenafil Citrate for Erectile Dysfunction in Men With Multiple Sclerosis: A Double-Blind, Placebo Controlled, Randomized Study

Journal of Urology

Volumn 181, Issue 1, 2009, Pages 252-258

  Safarinejad, Mohammad Reza ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

erectile dysfunction; multiple sclerosis; sexual behavior; sildenafil; therapeutics

Indexed keywords

PLACEBO; SILDENAFIL;

ADULT; ARTICLE; CEREBROVASCULAR ACCIDENT; CLINICAL EVALUATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DEMOGRAPHY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; ERECTILE DYSFUNCTION; EVOKED SOMATOSENSORY RESPONSE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; PATIENT SATISFACTION; PENIS ERECTION; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SEXUAL INTERCOURSE; TREATMENT OUTCOME; URODYNAMICS;

ADULT; DOUBLE-BLIND METHOD; ERECTILE DYSFUNCTION; EVOKED POTENTIALS, SOMATOSENSORY; HUMANS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PURINES; SULFONES;

EID: 57149085461     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.juro.2008.09.003     Document Type: Article

References (16)

1. Johnson S.K. The neuropsychology of multiple sclerosis. Dis Mon 53 (2007) 172
2. van den Noort S., and Holland N.J. Multiple Sclerosis in Clinical Practice (1999), Demos Medical Publishing Inc, New York
3. Zorzon M., Zivadinov R., Bosco A., Bragadin L.M., Moretti R., Bonfigli L., et al. Sexual dysfunction in multiple sclerosis: a case-control study. I. Frequency and comparison of groups. Mult Scler 5 (1999) 418
4. Zivadinov R., Zorzon M., Locatelli L., Stival B., Monti F., Nasuelli D., et al. Sexual dysfunction in multiple sclerosis: a MRI, neurophysiological and urodynamic study. J Neurol Sci 210 (2003) 73
5. Fowler C.J., Miller J.R., Sharief M.K., Hussain I.F., Stecher V.J., and Sweeney M. A double blind, randomised study of sildenafil citrate for erectile dysfunction in men with multiple sclerosis. J Neurol Neurosurg Psychiatry 76 (2005) 700
6. Polman C.H., Reingold S.C., Edan G., Filippi M., Hartung H.P., Kappos L., et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria". Ann Neurol 58 (2005) 840
7. Kurtzke J.F. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33 (1983) 1444
8. Del Popolo G., Li Marzi V., Mondaini N., and Lombardi G. Time/duration effectiveness of sildenafil versus tadalafil in the treatment of erectile dysfunction in male spinal cord-injured patients. Spinal Cord 42 (2004) 643
9. Giuliano F., Sanchez-Ramos A., Löchner-Ernst D., Del Popolo G., Cruz N., Leriche A., et al. Efficacy and safety of tadalafil in men with erectile dysfunction following spinal cord injury. Arch Neurol 64 (2007) 1584
10. Jarow J.P., Burnett A.L., and Geringer A.M. Clinical efficacy of sildenafil citrate based on etiology and response to prior treatment. J Urol 162 (1999) 722
11. Barak Y., Achiron A., Elizur A., Gabbay U., Noy S., and Sarova-Pinhas I. Sexual dysfunction in relapsing-remitting multiple sclerosis: magnetic resonance imaging, clinical, and psychological correlates. J Psychiatry Neurosci 21 (1996) 255
12. Janardhan V., and Bakshi R. Quality of life and its relationship to brain lesions and atrophy on magnetic resonance images in 60 patients with multiple sclerosis. Arch Neurol 57 (2000) 1485
13. Yang C.C., Bowen J.D., Kraft G.H., Uchio E.M., and Kromm B.G. Physiologic studies of male sexual dysfunction in multiple sclerosis. Mult Scler 7 (2001) 249
14. Padma-Nathan H., Steers W.D., and Wicker P.A. Efficacy and safety of oral sildenafil in the treatment of erectile dysfunction: a double blind, placebo-controlled study of 329 patients. Sildenafil Study Group. Int J Clin Pract 52 (1998) 375
15. Atiemo H.O., Szostak M.J., and Sklar G.N. Salvage of sildenafil failures referred from primary care physicians. J Urol 170 (2003) 2356
16. Ströberg P., Hedelin H., and Ljunggren C. Prescribing all phosphodiesterase 5 inhibitors to a patient with erectile dysfunction-a realistic and feasible option in everyday clinical practice-outcomes of a simple treatment regime. Eur Urol 49 (2006) 900