PCNA indexing as a preclinical immunohistochemical biomarker for testicular toxicity

Biotechnic and Histochemistry

Volumn 83, Issue 5, 2008, Pages 211-220

  Lawrence, D ^a   Nagele, R G ^b   Wang, C Y ^a   Damiano, B P ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^b UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

Author keywords

Biomarker; Drug discovery; Immunohistochemistry; Pathology; PCNA; Proliferating cell nuclear antigen; Seminiferous tubules; Spermatogonia; Testes; Toxicity

Indexed keywords

ALCOHOL; BIOLOGICAL MARKER; CYCLINE; CYCLOPHOSPHAMIDE; EOSIN; FORMALDEHYDE; HEMATOXYLIN; PARAFFIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; CELL LABELING; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DIAGNOSTIC VALUE; EARLY DIAGNOSIS; EMBEDDING; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; RELIABILITY; REPRODUCTIVE TOXICITY; SEMINIFEROUS TUBULE; SENSITIVITY ANALYSIS; SPERMATOGENESIS; SPERMATOZOON COUNT; TESTIS WEIGHT;

ANIMALS; BIOLOGICAL MARKERS; DRUG EVALUATION, PRECLINICAL; IMMUNOHISTOCHEMISTRY; MALE; PROLIFERATING CELL NUCLEAR ANTIGEN; RATS; RATS, SPRAGUE-DAWLEY; SEMINIFEROUS TUBULES; SENSITIVITY AND SPECIFICITY; SPERMATOGONIA; TESTIS;

ANIMALIA; RATTUS;

EID: 57049157591     PISSN: 10520295     EISSN: 14737760     Source Type: Journal    
DOI: 10.1080/10520290802521804     Document Type: Article

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