The first example of tautomerism in 2-aminopyrroles: effect of structure and solvent

Tetrahedron Letters

Volumn 50, Issue 1, 2009, Pages 12-14

  De Rosa, Michael ^a   Arnold, David ^a   O'Hare, Bernie ^b  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOPYRROLE DERIVATIVE; 2,4,5,6 TETRACHLOROPYRIMIDINE; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ADDITION REACTION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL REACTION; ELIMINATION REACTION; HYDROGEN BOND; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 57049152304     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2008.10.100     Document Type: Article

References (21)

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11. oC. NMR data is given below.
12. 3OD): δ 7.00-6.99 (d, 1H, J = 4.0 Hz), 6.32-6.31 (d, 1H, J = 4.0 Hz), 3.76-3.71 (q, 2H, J = 7.26 Hz), 1.32-1.29 (t, 3H, J = 7.26 Hz).
13. De Rosa, M.; Arnold, D. J. Org. Chem., accepted for publication.
14. 3 (ca. 1 mL) was put into a vial and cooled in liquid nitrogen. Solid 4b was put on top of the frozen solvent and the solvent was allowed to melt. As soon as the sample dissolved in the cold solvent, it was transferred to an NMR tube and placed in the NMR probe at 218 K.
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