Sex steroids and bone turnover markers in men with symptomatic vertebral fractures

Bone

Volumn 43, Issue 6, 2008, Pages 999-1005

  Tuck, S P ^a   Scane, A C ^b   Fraser, W D ^c   Diver, M J ^c   Eastell, R ^d   Francis, R M ^e  

^a JAMES COOK UNIVERSITY HOSPITAL   (United Kingdom)

^b Hunter Rural Aged Care Assessment Team   (Australia)

^c ROYAL LIVERPOOL UNIVERSITY HOSPITAL   (United Kingdom)

^d NORTHERN GENERAL HOSPITAL   (United Kingdom)

^e NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Bone mineral density; Bone turnover; Male osteoporosis; Sex steroids; Vertebral fractures

Indexed keywords

ALBUMIN; ALKALINE PHOSPHATASE BONE ISOENZYME; BIOLOGICAL MARKER; CREATININE; DEOXYPYRIDINOLINE; ESTRADIOL; SEX HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE;

ADULT; AGED; ARTICLE; BODY HEIGHT; BODY WEIGHT; BONE DENSITY; BONE TURNOVER; CONTROLLED STUDY; ESTRADIOL BLOOD LEVEL; FEMUR; FEMUR NECK; HIP; HUMAN; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; RADIOIMMUNOASSAY; SYMPTOMATOLOGY; TESTOSTERONE BLOOD LEVEL; VERTEBRA FRACTURE;

ABSORPTIOMETRY, PHOTON; AGED; BIOLOGICAL MARKERS; BONE DENSITY; BONE REMODELING; CASE-CONTROL STUDIES; ESTRADIOL; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED; PARATHYROID HORMONE; SEX HORMONE-BINDING GLOBULIN; SPINAL FRACTURES; TESTOSTERONE;

EID: 57049105717     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2008.08.123     Document Type: Article

References (57)

1. NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis and Therapy. Osteoporosis prevention, diagnosis, and therapy. JAMA 285 6 (2001) 785-795
2. van Staa T.P., Dennison E.M., Leufkens H.G.M., and Cooper C. Epidemiology of fractures in England and Wales. Bone 29 (2001) 517-522
3. US Department of Health and Human Resources. Bone health and osteoporosis. A report of the surgeon general. Rockville, MD; 2004: USDHHS.
4. O'Neill T.W., Cooper C., Finn J.D., Lunt M., Purdie D., Reid D.M., et al. Incidence of distal forearm fractures in British men and women. Osteoporos. Int. 12 (2001) 555-558
5. Center J.R., Nguyen T.V., Schnieder D., Sambrook P.M., and Eisman J.A. Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet 353 (1999) 878-882
6. Poor G., Jacobsen S.J., and Melton L.J. Mortality after hip fracture. Facts Res. Gerontol. 7 (1994) 91-109
7. Poor G., Atkinson E.J., Lewallen D.G., O'Fallon W.M., and Melton L.J. Age-related hip fracture in men: clinical spectrum and short-term outcome. Osteoporos. Int. 5 (1995) 419-426
8. Scane A.C., Francis R.M., Sutcliffe A.M., Francis M.J.D., Rawlings D.J., and Chapple C.L. Case-control study of the pathogenesis and sequelae of symptomatic vertebral fractures in men. Osteoporos. Int. 9 (1999) 91-97
9. Stepan J.J., Lachman M., Zverina J., Pacovsky V., and Baylink D.J. Castrated men exhibit bone loss: effect of calcitonin treatment on biochemical indices of bone remodelling. J. Clin. Endocrinol. Metab. 69 (1989) 523-527
10. Alibhai S.M.H., Gogov S., and Allibhai Z. Long-term side effects of androgen deprivation therapy in men with non-metastatic prostate cancer: a systematic literature review. Clinical Reviews in Oncology/Haematology 60 (2006) 201-215
11. Morishima A., Grumbach M.M., Simpson E.R., Fisher C., and Qin K. Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J. Clin. Endocrinol. Metab. 80 (1995) 3689-3698
12. Smith E.P., Boyd J., Frank G.R., Takahashi H., Cohen R.M., Specker B., et al. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. NEJM 331 (1994) 1056-1061
13. Amin S., Zhang Y., Saiven C.T., Evans S.R., Hannan M.T., Kiel D.P., et al. Association of hypogonadism and oestradiol levels with bone mineral density in elderly men from the Framingham Study. Ann. Intern. Med. 133 12 (2000) 951-963
14. Barrett-Conner E., Mueller J.E., von Muhlen D.G., Laughlin G.A., Schneider D.L., and Sartoris D.J. Low levels of oestradiol are associated with vertebral fractures in older men, but not women: the Rancho Bernardo Study. J. Clin. Endocrinol. Metab. 85 1 (2000) 219-223
15. Falahati-Nini A., Riggs B.L., Atkinson E.J., O'Fallon W.M., Eastell R., and Khosla S. Relative contributions of testosterone and oestrogen in regulating bone resorption and formation in normal men. J. Clin. Invest. 106 (2000) 1553-1560
16. Legrand E., Hedde C., Gallois Y., Degasne I., Boux de Casson F., Mathieu E., et al. Osteoporosis in men: a potential role for the sex hormone binding globulin. Bone 29 (2001) 90-95
17. Diaz-Guerra G.M., Hawkins F., Rapado A., Ruiz-Diaz M.A., and Diaz-Curiel M. Hormonal and anthropometric predictors of bone mass in healthy elderly men: major effect of sex hormone binding globulin, parathyroid hormone and body weight. Osteoporos. Int. 12 (2001) 178-184
18. Khosla S., Melton III L.J., Atkinson E.J., O'Fallon W.M., Klee G.G., and Riggs B.L. Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen. J. Clin. Endocrinol. Metab. 83 (1998) 2266-2274
19. Szulc P., Munoz F., Claustrat B., Garnero P., Marcland F., Duboeaf F., et al. Bioavailable estradiol may be an important determinant of osteoporosis in men: the MINOS Study. J. Clin. Endocrinol. Metab. 86 1 (2001) 192-199
20. Evans S.F., and Davie M.W. Low body size and elevated SHBG distinguish men with idiopathic vertebral fracture. Calcif. Tissue Int. 70 (2002) 9-15
21. Pietschmann P., Kudlacek S., Grisar J., Spitzauer S., Woloszczak W., Will Vonseder R., et al. Bone turnover markers and sex hormones in men with idiopathic osteoporosis. Eur. J. Clin. Investig. 31 5 (2001) 444-451
22. Murphy S., Khaw K.T., Prentice A., and Compston J.E. Relationships between parathyroid hormone, 25-hydroxyvitamin D, and bone mineral density in elderly men. Age Ageing 22 (1993) 198-204
23. Kurland E.S., Rosen C.T., Cosman F., McMahon D., Chan F., Shane E., et al. Insulin-like growth factor 1 in men with idiopathic osteoporosis. J. Clin. Endocrinol. Metab. 82 (1997) 2799-2805
24. Daniell H.W. Hypogonadism in men consuming sustained-action oral opioids. J. Pain 3 (2002) 377-384
25. Vermeulen A., Verdonck L., and Kaufman J.M. A critical evaluation of simple methods for the estimation of free testosterone in serum. J. Clin. Endocrinol. Metab. 84 (1999) 3666-3672
26. Tremblay R.R., and Dube J.Y. Plasma concentration of free and non TEBG bound testosterone of women on oral contraceptives. Contraception 10 (1974) 599-605
27. Brier B.H., Gallaher B.W., and Gluckman P.D. Radioimmunoassay for insulin-like growth factor-1: solutions to some potential problems and pitfalls. J. Endocrinol. 128 (1991) 347-357
28. Tuck S.P., Raj N., and Summers G.D. Is distal forearm fracture in men due to osteoporosis?. Osteoporos. Int. 13 (2002) 630-636
29. Pande I., O'Neill T.W., Pritchard C., Scott D.L., and Woolf A.D. Bone mineral density, hip axis length and risk of hip fractures in men: results from the Cornwall Hip Fracture Study. Osteoporos. Int. 11 (2000) 866-870
30. Lournea C., Soudan B., d, 'Herbournez M., Pigny P., Duquesnoy B., and Cortet B. Sex hormone-binding globulin, estradiol and bone turnover markers in male osteoporosis. Bone 34 6 (2004) 933-939
31. Center J.R., Nguyen T.V., Sambrook P.N., and Eisman J.A. Hormonal and biochemical parameters and osteoporotic fractures in elderly men. J. Bone Miner. Res. 15 7 (2000) 1405-1411
32. Mohr B.A., Bhasin S., Link C.L., O'Donnell A.B., and McKinlay J.B. The effect of changes in adiposity on testosterone levels in older men: longitudinal results from the Massachusetts Male Aging Study. Eur. J. Endocrinol. 155 (2006) 443-452
33. Slemenda C.W., Longcope C., Zhou L., Hui S.L., Peacock M., and Johnston C.C. Sex steroids and bone mass in older men: positive associations with serum estrogens and negative associations with androgens. J. Clin. Invest. 100 7 (1997) 1755-1759
34. Leder B.Z., LeBlanc K.M., Schoenfeld D.A., Eastell R., and Finkelstein J.S. Differential effects of androgens and oestrogens on bone turnover in normal men. J. Clin. Endocrinol. Metab. 88 1 (2003) 204-210
35. Rucker D., Ezzat S., Diamandi A., Khosravi J., and Hanley D.A. IGF-1 and testosterone levels as predictors of bone mineral density in healthy, community dwelling men. Clin. Endocrinol. 60 4 (2004) 491-499
36. Leifke E., Gorenoi V., Wichers C., von zur Muhlen A., von Buren E., and Brabant G. Age-related changes of sex hormones, insulin-like growth factor-1 and sex hormone binding globulin levels in men: cross sectional data from a healthy male cohort. Clin. Endocrinol. 53 6 (2000) 689-695
37. Blain H., Vuillemin A., Blain A., Guillemeni F., De Talance N., Doucet B., et al. Age related femoral bone loss in men: evidence of hyperparathyroidism and insulin-like growth factor 1 deficiency. Journal of Gerontology Series A Biological Sciences and Medical Sciences 59 12 (2004) 1285-1289
38. Rosen C.J., and Johansson A. IGF's in the treatment of osteoporosis. In: Bilezikian J.P., Raisz L., and Rodean G. (Eds). Principles of Bone Biology (1996), San Diego Academic Press 1011-1099
39. Rosen C.J. Growth hormone, insulin-like growth factors and the senescent skeleton: Ponce de Leon's Fountain revisited. J. Cell. Biochem. 58 (1994) 360-365
40. Canalis E., Centrella M., Burch W., and McCarthy T.L. Insulin-like growth factor 1 mediates selective anabolic effects of parathyroid hormone in bone cultures. J. Clin. Invest. 83 (1989) 60-65
41. Jones J.I., and Clemmons D.R. Insulin-like growth factors and their binding proteins: biological actions. Endocr. Rev. 16 (1995) 3-32
42. Rosen C.J., Donahue L.R., and Hunter S.J. Insulin-like growth factors and bone: the osteoporosis connection. Proc. Soc. Exp. Biol. Med. 206 (1994) 83-102
43. Cuddihy M.T., Gabriel S.E., Crowson C.S., O, 'Fallon W.M., and Melton L.J. Forearm fractures as predictors of subsequent osteoporotic fractures. Osteoporos. Int. 9 6 (1999) 469-475
44. Center J.R., Bliuc D., Nguyen T.V., and Eisman J.A. Risk of subsequent fracture after low trauma fracture in men and women. JAMA 297 4 (2007) 387-394
45. Lewis C.E., Ewing S.K., Taylor B.C., Shikany J.M., Fink H.A., Ensrud K.E., et al. Predictors of non-spine fracture in elderly men: the MrOS Study. J. Bone Miner. Res. 22 2 (2007) 211-219
46. White S.C., Atchinson K.A., Gornbein J.A., Nattiv A., Paganini-Hill A., and Service S.K. Risk factors for fractures in older men and women: The Leisure World Cohort study. Gend. Med. 3 2 (2006) 110-123
47. Nguyen T., Sambrook P., Kelly P., Jones G., Lord S., Freund J., et al. Prediction of osteoporotic fractures by postural instability and bone density. BMJ 307 6912 (1993) 1111-1115
48. Cummings S.R., Cawthon P.M., Ensrud K.E., Cauley J.A., Fink H.A., and Orwoll E.S. BMD and risk of hip and nonvertebral fractures in older men: a prospective study and comparison with older women. J. Bone Miner. Res. 21 10 (2006) 1550-1556
49. Gonnelli S., Cepollaro C., Gennari L., Montagnani A., Caffarelli C., Merlotti D., et al. Quantitative ultrasound and dual-energy X-ray absorptiometry in the prediction of fragility fracture in men. Osteoporos. Int. 16 8 (2005) 963-968
50. Melton L.J., Beck T.J., Amin S., Khosla S., Achenbach S.J., Oberg A.L., et al. Contributions of bone density and structure to fracture risk assessment in men and women. Osteoporos. Int. 16 5 (2005) 460-467
51. Szulc P., Munoz F., Duboeuf F., Marchand F., and Delmas P.D. Bone mineral density predicts fractures in elderly men: the MINOS Study. Osteoporos. Int. 16 10 (2005) 1184-1192
52. Nguyen T.V., Center J.R., Sambrook P.N., and Eisman J.A. Risk factors for proximal humerus, forearm and wrist fractures in elderly men and women: the Dubbo Osteoporosis Epidemiology Study. Am. J. Epidemiol. 153 6 (2001) 587-595
53. Meir C., Nguyen T.V., Center J.R., Seibel M.J., and Eisman J.A. Bone resorption and osteoporotic fractures in elderly men: the Dubbo Osteoporosis Epidemiology Study. J. Bone Miner. Res. 20 4 (2005) 579-589
54. Center J.R., Nguyen T.V., Sambrook P.N., and Eisman J.A. Hormonal and biochemical parameters and osteoporotic fractures in elderly men. J. Bone Miner. Res. 15 7 (2000) 1405-1411
55. Meir C., Nguyen T.V., Handelsman D.J., Schindler C., Kushmir M.M., Rockwood A.L., et al. Endogenous sex hormones and incident fracture risk in older men. Arch. Intern. Med. 168 1 (2008) 47-54
56. Akesson K., Ljunghall S., Jonsson B., Sernbo I., Johnell O., Gardsell P., et al. Assessment of biochemical markers of bone metabolism in relation to the occurrence of fracture: a retrospective and prospective population based study of women. J. Bone Miner. Res. 11 (1995) 1823-1829
57. Stoffel K., Engler H., Kuster M., and Reisen W. Changes in biochemical markers after lower limb fractures. Clin. Chem. 1 (2007) 131-134