The acute and chronic phases of chronic relapsing experimental autoimmune encephalomyelitis (CR EAE) are ameliorated by the peroxynitrite decomposition catalyst, 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrinatoiron (III) chloride, (FeTPPS)

European Journal of Pharmacology

Volumn 601, Issue 1-3, 2008, Pages 88-93

  Bolton, Christopher ^a   Scott, Gwen S ^a   Smith, Terence ^a   Flower, Roderick J ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Experimental autoimmune encephalomyelitis; FeTPPS; Metalloporphyrin; Neuroinflammation; Peroxynitrite

Indexed keywords

5,10,15,20 TETRAKIS(4 SULFONATOPHENYL)PORPHYRINATOIRON CHLORIDE; DRUG VEHICLE; METALLOPORPHYRIN; PEROXYNITRITE; UNCLASSIFIED DRUG;

ACUTE DISEASE; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CATALYSIS; CHRONIC DISEASE; CONTROLLED STUDY; DRUG EFFICACY; HISTOPATHOLOGY; ISOMERIZATION; MALE; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; REMISSION;

ACUTE DISEASE; ANIMALS; CATALYSIS; CHRONIC DISEASE; DISEASE PROGRESSION; DRUG ADMINISTRATION SCHEDULE; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ISOMERISM; MALE; METALLOPORPHYRINS; MICE; MICE, BIOZZI; PEROXYNITROUS ACID; RECURRENCE;

EID: 57049105113     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.10.029     Document Type: Article

References (61)

1. Badn W., Visse E., Darabi A., Smith K.E., Salford L.G., and Siesjo P. Postimmunisation with IFA-gamma-secreting glioma cells combined with the inducible nitric oxide inhibitor mercaptoethylguanidine prolongs survival of rats with intracerebral tumors. J. Immunol. 179 (2007) 4231-4238
2. Beckman J.S., Beckman T.W., Chen J., Marshall P.A., and Freeman B.A. Apparent hydroxyl radical production by peroxynitrite: implication for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. U. S. A. 87 (1990) 1620-1624
3. Brahn E., Banguerigo M.L., Firestein G.S., Boyle D.L., Salzman A.L., and Szabo C. Collagen induced arthritis: reversal by mercaptoethylguanidine, a novel antiiflammatory agent with a combined mechanism of action. J. Rheumatol. 25 (1998) 1785-1793
4. Bolton C., O'Neill J.K., Allen S.J., and Baker D. Regulation of chronic relapsing experimental allergic encephalomyelitis by endogenous and exogenous glucocorticoids. Int. Arch. Allergy Immunol. 114 (1997) 74-80
5. Calabrese V., Scapaghini G., Ravagna A., Bella R., Foresti R., Bates T.E., Giuffrida Stella A.M., and Pennisi G. Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels. J. Neurosci. Res. 70 (2002) 580-587
6. Castello P.R., Drechsel D.A., Day B.J., and Patel M. Inhibition of mitochondrial hydrogen peroxide production by lipophilic metalloporphyrins. J. Pharmacol. Exp. Ther. 324 (2008) 970-976
7. Chirino Y.I., Hernandez-Pando R., and Pedraza-Chaverri J. Peroxynitrite decomposition catalyst ameliorates renal damage and protein nitration in cisplatin-induced nephrotoxicity in rats. BMC Pharmacol. 4 (2004) 20
8. Choi I.Y., Lee S.J., Nam W., Park J.S., Ko K.H., Kim H.C., Shin C.Y., Chung J.H., Noh S.K., Choi C.R., Shin D.H., and Kim W.K. Augmented death in immunostimulated astrocytes deprived of glucose: inhibition by an iron porphyrin FeTMPyP. J. Neuroimmunol. 112 (2001) 55-62
9. Compston A., and Coles A. Multiple sclerosis. Lancet 359 (2002) 1221-1231
10. Cross A.H., Manning P.T., Stern M.K., and Misko T.P. Evidence for the production of peroxynitrite in inflammatory CNS demyelination. J. Neuroimmunol. 80 (1997) 121-130
11. Cross A.H., Manning P.T., Keeling R.M., Schmidt R.E., and Misko T.P. Peroxynitrite formation within the central nervous system in active multiple sclerosis. J. Neuroimmunol. 88 (1998) 45-56
12. Cross A.H., San M., Stern M.K., Keeling R.M., Salvemini D., and Misko T.P. A catalyst of peroxynitrite decomposition inhibits murine experimental allergic encephalomyelitis. J. Neuroimmunol. 107 (2000) 21-28
13. Croxford J.L., Pryce G., Jackson S.J., Ledent C., Giovannoni G., Pertwee R.G., Yamamura T., and Baker D. Cannabinoid-mediated neuroprotection, not immunosuppression, may be more relevant to multiple sclerosis. J. Neuroimmunol. 193 (2008) 120-129
14. Cuzzocrea S., Mazzon E., Di Paola R., Esposito E., Macarthur H., Matuschak G.M., and Salvemini D. A role for nitric oxide-mediated peroxynitrite formation in a model of endotoxin induced shock. J. Pharmacol. Exp. Ther. 319 (2006) 73-81
15. Dhar A., Kaundal R.K., and Sharma S.S. Neuroprotective effects of FeTMPyP: a peroxynitrite decomposition catalyst in global cerebral ischemia models in gerbils. Pharmacol. Res. 54 (2006) 311-316
16. Drulovic J., Dujmovic I., Stojsavljevic N., Mesaros S., Andjelkovic S., Miljkovic D., Peric V., Dragutinovic G., Marinkovic J., Levic Z., and Mostarica Stolkovic M. Uric acid levels in sera from patients with multiple sclerosis. J. Neurol. 248 (2001) 121-126
17. Groom A.J., Smith T., and Turski L. Multiple sclerosis and glutamate. Ann. N.Y. Acad. Sci. 993 (2003) 229-275
18. Groves J.T. Peroxynitrite: reactive, invasive and enigmatic. Curr. Opin. Chem. Biol. 3 (1999) 226-235
19. Hooper D.C., Spitsin S., Khan R.B., Champion J.M., Dickson G.M., Chaudry I., and Koprowski H. Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 675-680
20. Hooper D.C., Scott G.S., Zborek A., Mikheeva T., Kean R.B., Koprowski H., and Spitsin S.V. Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood-CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis. FASEB J. 14 (2000) 691-698
21. Hooper D.C., Kean R.B., Scott G.S., Spitsin S.V., Mikheeva T., Morimoto K., Bette M., Rohrenbeck A.M., Dietzschold B., and Weihe E. The CNS inflammatory response to neurotropic virus infection is peroxynitrite-dependent. J. Immunol. 167 (2001) 3470-3477
22. Imam S.Z., el-Yazal J., Newport G.D., Itzhak Y., Cadet J.L., Slikker W., and Ali S.F. Methamphetamine-induced dopaminergic neurotoxicity: role of peroxynitrite and neuroprotective role of antioxidants and peroxynitrite decomposition catalysts. Ann. N. Y. Acad. Sci. 939 (2001) 366-380
23. Ischiropoulos H., Zhu L., and Beckman J.S. Peroxynitrite formation from macrophage-derived nitric oxide. Arch. Biochem. Biophys. 198 (1992) 446-451
24. Jack C., Antel J., Bruck W., and Kuhlmann T. Contrasting potential of nitric oxide and peroxynirite to mediate oligodendrocyte injury in multiple sclerosis. Glia 55 (2007) 926-934
25. Kang J.L., Lee H.S., Jung H.J., and Kim H.J. Iron tetrakis (N-methyl-4′-pyridyl) porphyrinato inhibits proliferative activity of thymocytes by blocking activation of p38 mitogen-activated protein kinase, nuclear factor-kappaB, and interleukin-2 secretion. Toxicol. Appl. Pharmacol. 191 (2003) 147-155
26. Kastenbauer S., Koedel U., and Pfister H.W. Role of peroxynitrite as a mediator of pathophysiological alterations in experimental pneumococcal meningitis. J. Infect. Dis. 180 (1999) 1164-1170
27. Kean R.B., Spitsin S.V., Mikheeva T., Scott G.S., and Hooper D.C. he peroxynitrite scavenger uric acid prevents inflammatory cell invasion into the CNS in experimental allergic encephalomyelitis through maintenance of blood-CNS barrier integrity. J. Immunol. 167 (2000) 3470-3477
28. Kim J.Y., Lee K.H., Lee B.K., and Ro J.Y. Peroxynitrite modulates release of inflammatory mediators from guinea pig lung mast cells activated by antigen-antibody reaction. Int. Arch. Allergy Immunol. 137 (2005) 104-114
29. Knepler J.L., Taher L.N., Gupta M.P., Patterson C., Pavalko F., Ober M.D., and Hart C.M. Peroxynitrite causes endothelial cell monolayer barrier dysfunction. Am. J. Physiol. 281 (2001) C1064-C1075
30. Koprowski H., Spitsin S.V., and Hooper D.C. Prospects for the treatment of multiple sclerosis by raising serum levels of uric acid, a scavenger of peroxynitrite. Ann. Neurol. 49 (2001) 139
31. Lancel S., Tissier S., Mordon S., Marechal X., Depontieu F., Scherpereel A., Chopin C., and Neviere R. Peroxynitrite decomposition catalysts prevent myocardial dysfunction and inflammation in endotoxemic rats. J. Am. Coll. Cardiol. 243 (2004) 2348-2358
32. Liu J.S., Zhao M.L., Brosnan C.F., and Lee S.C. Expression of inducible nitric oxide synthase and nitrotyrosine in multiple sclerosis lesions. Am. J. Pathol. 158 (2001) 2057-2066
33. Misko T.P., Highkin M.K., Veenhuizen A.W., Manning P.T., Stern M.K., Currie M.G., and Salvemini D. Characterization of the cytoprotective action of peroxynitrite decomposition catalysts. J. Biol. Chem. 273 (1998) 15646-15653
34. Mitrovic B., Ignarro L.J., Montestruque S., Smoll A., and Merrill J.E. Nitric oxide as a potential pathological mechanism in demyelination: its differential effects on primary glial cells in vitro. Neurosci. 61 (1994) 575-585
35. Moochhala S.M., Lu J., Xing M.C., Anuar F., Ng K.C., Yang K.L., Whiteman M., and Atan S. Mercaptoethylguanidine inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression induced in rats after fluid-percussion brain injury. J. Trauma 59 (2005) 450-457
36. Mousavizadeh K., Dehpour A.R., Mihages A., and Ghafouifar P. Uric acid: a novel treatment strategy for multiple sclerosis. Trends Pharmacol. Sci. 24 (2003) 563-564
37. Oleszak E.L., Zaczynska E., Bhattacharjee M., Buturoi C., Legido A., and Katsetos C.D. Inducible nitric oxide synthase and nitrotyrosine are found in monocyte/ macrophages and/or astrocytes in acute, but not in chronic, multiple sclerosis. Clin. Diagn. Lab. Immunol. 5 (1998) 438-445
38. Patel M., and Day B.J. Metalloporphyrin class of therapeutic catalytic antioxidants. Trends Pharmacol. Sci. 20 (1999) 359-364
39. Phares T.W., Fabis M.J., Brimer C.M., Kean R.B., and Hooper D.C. A peroxynitrite-dependent pathway is responsible for blood-brain barrier permeability changes during a central nervous system inflammatory response: TNF-alpha is neither necessary or sufficient. J. Immunol. 178 (2007) 7334-7343
40. Pryor W.A., and Squadrito G.L. The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide. Am. J. Physiol. 268 (1995) L699-L721
41. Qi X., Lewin A.S., Sun L., Hauswirth W.W., and Guy J. Suppression of mitochondrial oxidative stress provides long-term neuroprotection in experimental optic neuritis. Invest. Ophthalmol. Vis. Sci. 48 (2007) 681-691
42. Salom M.G., Ceron S.N., Rodriquez F., Lopez B., Hernandez I., Martinez J.G., Losa A.M., and Fenoy F.J. Heme oxygenase-1 induction improves ischemic renal failure: a role for nitric oxide and peroxynitrite. Am. J. Physiol. Heart Circ. Physiol. 293 (2007) H3542-H3549
43. Scott G.S., Kean R.B., Southan G.J., Szabo C., and Hooper D.C. Effect of mercaptoethylguanidine scavengers of peroxynitrite on the development of experimental allergic encephalomyelitis in PLSJL mice. Neurosci. Lett. 311 (2001) 125-128
44. Scott G.S., Hake P., Kean R.B., Virag L., Szabo C., and Hooper D.C. Role of poly (ADP) ribose synthetase activation in the development of experimental allergic encephalomyelitis. J. Neuroimmunol. 117 (2001) 79-87
45. Scott G.S., Virag L., Szabo C., and Hooper D.C. Peroxynitrite-induced oligodendrocyte toxicity is not dependent on poly (ADP-ribose) polymerase activation. Glia 41 (2003) 105-116
46. Scott G.S., Szabo C., and Hooper D.C. Poly(ADP-ribose) polymerase activity contributes to peroxynitrite-induced spinal cord neuronal cell death in vitro. J. Neurotrauma. 21 (2004) 1255-1263
47. Shimanovich R., and Groves J.T. Mechanisms of peroxynitrite decomposition catalyzed by FeTMPS, a bioactive sulfonated iron porphyrin. Arch. Biochem. Biophys. 387 (2001) 307-317
48. Smith T., Groom A., Zhu B., and Turski L. Autoimmune encephalomyelitis ameliorated by AMPA antagoinists. Nat. Med. 6 (2000) 62-66
49. Sotgiu S., Pugliatti M., Sanna A., Sotgiu A., Fois M.L., Arru G., and Rosati G. Serum uric acid and multiple sclerosis. Neurol. Sci. 23 (2002) 183-188
50. Spitsin S., Hooper D.C., Mikheeva T., and Koprowski H. Uric acid levels in patients with multiple sclerosis: analysis in mono- and dizygotic twins. Mult. Scler. 7 (2001) 165-166
51. Stefanutti G., Pierro A., Smith V.V., Klein N.J., and Eaton S. Peroxynitrite decomposition catalyst FeTMPyP provides partial protection against intestinal ischemia and reperfusion injury in infant rats. Pediatr. Res. 62 (2007) 43-48
52. Szabo C. The pathophysiological role of peroxynitrite in shock, inflammation and ischemia-reperfusion injury. Shock. 6 (1996) 79-88
53. Szabo C., Mabley J.G., Moeller S.M., Shimanovich R., Pacher P., Virag L., Soriano F.G., Van Duzer J.H., Williams W., Salzman A.L., and Groves J.T. Part I: pathogenetic role of peroxynitrite in the development of diabetes and diabetic vascular complications: studies with FP15, a novel potent peroxynitrite decomposition catalyst. Mol. Med. 8 (2002) 571-580
54. Thiyagarajan M., Kaul C.L., and Sharma S.S. Neuroprotective efficacy and therapeutic time window of peroxynitrite decomposition catalysts in focal cerebral ischemia in rats. Br. J. Pharmacol. 142 (2004) 899-911
55. Toncev G., Milicic B., Toncev S., and Samardzic G. Serum uric acid levels in multiple sclerosis patients correlate with activity of disease and blood brain barrier dysfunction. Eur. J. Neurol. 9 (2002) 221-226
56. Torreilles F., Salman-Tabcheh S., Guerin M., and Torreilles J. Neurodegenerative disorders: the role of peroxynitrite. Brain Res. Rev. 30 (1999) 153-163
57. Van der Veen R.C., Hinton D.R., Incardonna F., and Hofman F.M. Extensive peroxynitrite activity during progressive stages of central nervous system inflammation. J. Neuroimmunol. 77 (1997) 1-7
58. Xie Z., Wei M., Morgan T.E., Fabrizio P., Han D., Finch C.E., and Longo V.D. Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia. J. Neurosci. 22 (2002) 3484-3492
59. Yeo J.F., Ling S.F., Tang N., and Ong W.Y. Antinociceptive effect of CNS perxynitrite scavenger in a mouse model of orofacial pain. Exp. Brain Res. 184 (2008) 435-438
60. Yu X.W., Liu M.Y., Kennedy R.H., and Liu S.J. Both cGMP and peroxynitrite mediate chronic interleukin-6-induced negative inotropy in adult rat ventricular myocytes. J. Physiol. 566 (2005) 341-353
61. Zargari M., Allameh A., Sanati M.H., Tiraihi T., Lavasani S., and Emadyan O. Relationship between the clinical scoring and demyelination in central nervous system with total antioxidant capacity of plasma during experimental autoimmune encephalomyelitis development in mice. Neurosci. Lett. 412 (2007) 24-28