Human herpesvirus 6-associated limbic encephalitis in adult recipients of unrelated umbilical cord blood transplantation

Bone Marrow Transplantation

Volumn 42, Issue 10, 2008, Pages 693-695

  Mata S ^a   Guidi, S ^a   Nozzoli, C ^a   Orsi, A ^b   Pratesi, A ^c   Mascalchi, M ^c   Moretti, M ^a   Letizia, L ^a   Rombola G ^d   Sorbi, S ^a   Bosi, A ^a  

^a Azienda Ospedaliero Universitaria di Careggi ^*  (Italy)

^b Microbiology   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

^d Laboratory of Immunogenetics   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; FOSCARNET; GANCICLOVIR; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; THIOTEPA; VIRUS DNA;

ACUTE GRAFT VERSUS HOST DISEASE; ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ANTEROGRADE AMNESIA; BLURRED VISION; CASE REPORT; CEREBROSPINAL FLUID EXAMINATION; CONFUSION; CORD BLOOD STEM CELL TRANSPLANTATION; CYTOMEGALOVIRUS INFECTION; DRUG BLOOD LEVEL; DRUG MEGADOSE; FEMALE; GRAFT RECIPIENT; HEMORRHAGIC CYSTITIS; HUMAN; HUMAN HERPESVIRUS 6; HUMAN TISSUE; HYPONATREMIA; LETTER; MALE; MUCOSA INFLAMMATION; MULTIPLE CYCLE TREATMENT; PARANEOPLASTIC NEUROPATHY; PERSONALITY DISORDER; PRIORITY JOURNAL; RADIATION DOSE FRACTIONATION; RETROSPECTIVE STUDY; SEPSIS; TONIC CLONIC SEIZURE; VIRUS REACTIVATION; WHOLE BODY RADIATION;

ADULT; CORD BLOOD STEM CELL TRANSPLANTATION; FEMALE; HERPESVIRUS 6, HUMAN; HUMANS; LEUKEMIA, MYELOID, ACUTE; LIMBIC ENCEPHALITIS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; VIRUS ACTIVATION;

EID: 57049090598     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/bmt.2008.233     Document Type: Letter

References (12)

1. Safdar A, Rodriguez GH, De Lima MJ, Petropoulos D, Chemaly RF, Worth LL et al. Infections in 100 cord blood transplantations: Spectrum of early and late posttransplant infections in adult and pediatric patients 1996-2005. Medicine 2007; 86: 324-333.
2. Sashihara J, Tanaka-Taya K, Tanaka S, Amo K, Miyagawa H, Hosoi G et al. High incidence of human herpesvirus 6 infection with a high viral load in cord blood stem cell transplant recipients. Blood 2002; 100: 2005-2011.
3. Tomonari A, Takahashi S, Ooi J, Iseki T, Takasugi K, Uchiyama M et al Human herpesvirus 6 variant B infection in adult patients after unrelated cord blood transplantation. Int J Hematol 2005; 81 352-355.
4. Yamane A, Mori T, Suzuki S, Mihara A, Yamazaki R, Aisa Y et al. Risk factors for developing human herpesvirus 6 (HHV-6) reactivation after allogeneic hematopoietic stem cell transplantation and its association with central nervous system disorders. Biol Blood Marrow Transplant 2007; 13: 100-106.
5. Tanaka M, Taguchi J, Hyo R, Kawano T, Hashimoto C, Motomura S et al Human herpesvirus-6 encephalitis after unrelated cord blood transplantation. Leuk Lymphoma 2005; 46: 561-566.
6. Wainwright MS, Martin PL, Morse RP, Lacaze M, Provenzale JM, Coleman RE et al. Human herpesvirus 6 limbic encephalitis after stem cell transplantation. Ann Neurol 2001; 50: 612-619.
7. Seeley WW, Marty FM, Holmes TM, Upchurch K, Soiffer RJ, Antin JH et al. Post-transplant acute limbic encephalitis: Clinical features and relationship to HHV6. Neurology 2007; 69: 156-165.
8. Zerr DM, Gupta D, Huang ML, Carter R, Corey L. Effect of antivirals on human herpesvirus 6 replication in hematopoietic stem cell transplant recipient. Clin Infect Dis 2002; 34: 309-317.
9. Boutolleau D, Duros C, Bonnafous P, Caïola D, Karras A, Castro ND et al. Identification of human herpesvirus 6 variants A and B by primer-specific real-time PCR may help to revisit their respective role in pathology. J Clin Virol 2006; 35: 257-263.
10. Fotheringham J, Donati D, Akhyani N, Fogdell-Hahn A, Vortmeyer A, Heiss JD et al. Association of human herpesvirus-6B with mesial temporal lobe epilepsy. PLoS Med 2007; 4: E180.
11. Suen Y, Lee SM, Qian J, van de Ven C, Cairo MS. Dysregulation of lymphokine production in the neonate and its impact on neonatal cell mediated immunity. Vaccine 1998; 16: 1369-1377.
12. Clark DA, Nacheva EP, Leong HN, Brazma D, Li YT, Tsao EH et al. Transmission of integrated human herpesvirus 6 through stem cell transplantation: Implications for laboratory diagnosis. J Infect Dis 2006; 193: 912-916.