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Direct and adaptor-mediated substrate recognition by an essential AAA+ protease
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This study demonstrated that CtrA can be proteolyzed by purified ClpXP in vitro, and the reaction is not stimulated by RcdA. Thus, although RcdA is required for CtrA degradation in cells, it is not a traditional proteolytic adaptor for CtrA.
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Chien P., Perchuk B.S., Laub M.T., Sauer R.T., and Baker T.A. Direct and adaptor-mediated substrate recognition by an essential AAA+ protease. Proc Natl Acad Sci U S A 104 (2007) 6590-6595. This study demonstrated that CtrA can be proteolyzed by purified ClpXP in vitro, and the reaction is not stimulated by RcdA. Thus, although RcdA is required for CtrA degradation in cells, it is not a traditional proteolytic adaptor for CtrA.
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(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 6590-6595
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Chien, P.1
Perchuk, B.S.2
Laub, M.T.3
Sauer, R.T.4
Baker, T.A.5
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47
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2442531895
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Recruitment of a cytoplasmic response regulator to the cell pole is linked to its cell cycle-regulated proteolysis
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Ryan K.R., Huntwork S., and Shapiro L. Recruitment of a cytoplasmic response regulator to the cell pole is linked to its cell cycle-regulated proteolysis. Proc Natl Acad Sci U S A 101 (2004) 7415-7420
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(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 7415-7420
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Ryan, K.R.1
Huntwork, S.2
Shapiro, L.3
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48
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49649109935
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Architecture and inherent robustness of a bacterial cell-cycle control system
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This model of the Caulobacter cell cycle includes both the stalked and the swarmer cells, along with swarmer-to-stalked cell differentiation. The model predicts the combinations of conditions (e.g. DNA replication so slow that GcrA is degraded before ctrA transcription is induced) that could halt the cell cycle at different stages.
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Shen X., Collier J., Dill D., Shapiro L., Horowitz M., and McAdams H.H. Architecture and inherent robustness of a bacterial cell-cycle control system. Proc Natl Acad Sci U S A 105 (2008) 11340-11345. This model of the Caulobacter cell cycle includes both the stalked and the swarmer cells, along with swarmer-to-stalked cell differentiation. The model predicts the combinations of conditions (e.g. DNA replication so slow that GcrA is degraded before ctrA transcription is induced) that could halt the cell cycle at different stages.
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(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 11340-11345
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Shen, X.1
Collier, J.2
Dill, D.3
Shapiro, L.4
Horowitz, M.5
McAdams, H.H.6
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49
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38949110777
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A quantitative study of the division cycle of Caulobacter crescentus stalked cells
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This article describes a model of the division cycle of the Caulobacter stalked cell, including predictions of mutant phenotypes that have not yet been analyzed.
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Li S., Brazhnik P., Sobral B., and Tyson J.J. A quantitative study of the division cycle of Caulobacter crescentus stalked cells. PloS Comput Biol 4 (2008) e9. This article describes a model of the division cycle of the Caulobacter stalked cell, including predictions of mutant phenotypes that have not yet been analyzed.
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(2008)
PloS Comput Biol
, vol.4
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Li, S.1
Brazhnik, P.2
Sobral, B.3
Tyson, J.J.4
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