Evaluation of ChloraPrep (2% chlorhexidine gluconate in 70% isopropyl alcohol) for skin antisepsis in preparation for blood culture collection

Journal of Infection

Volumn 57, Issue 6, 2008, Pages 459-463

  McLellan, E ^a   Townsend, R ^a   Parsons, H K ^a  

^a NORTHERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

2 Chlorhexidine gluconate; Blood culture; ChloraPrep; Contaminants

Indexed keywords

2 PROPANOL; CHLORHEXIDINE GLUCONATE;

ANTISEPSIS; ARTICLE; BLOOD CULTURE; CONTROLLED STUDY; GRAM NEGATIVE BACTERIUM; HOSPITAL PHYSICIAN; HUMAN; MEDICAL EDUCATION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; SKIN DECONTAMINATION; STAPHYLOCOCCUS AUREUS; VEIN PUNCTURE;

2-PROPANOL; ANTISEPSIS; ATTITUDE OF HEALTH PERSONNEL; BLOOD; CHLORHEXIDINE; DISINFECTANTS; EDUCATION; HOSPITALS; HUMANS; SKIN;

EID: 56949101567     PISSN: 01634453     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinf.2008.08.012     Document Type: Article

References (19)

1. Bates D.W., Goldman L., and Lee T.H. Contaminant blood cultures and resource utilization. The true consequences of false positive results. JAMA 265 (1991) 365-369
2. Hibbard J.S., Mulberry G.K., and Brady A.R. A clinical study comparing the skin antisepsis and safety of ChloraPrep, 70% isopropyl alcohol and 2% aqueous chlorhexidine. J Infuse Nurs 25 (2002) 244-249
3. Smith SM, Eng RHK, Lopez AB, Valena FD. Reducing blood culture contamination: what makes the difference? Presented at 28th annual meeting of AIPC. Publication number 11-89.
4. Tepus D., Cox S.R., and Hazelett S. The effectiveness of ChloraPrep in the reduction of culture contamination rates in the Emergency Department. J Emerg Nurs 31 (2005) 133
5. Pease A.A., Wheat P.F., and Harris D.M. Antimicrobial susceptibility testing and biochemical identification using multipoint inoculation: 5 years' experience. Med Lab Sci 15 (1988) 28-33
6. Weinbaum F.I., Lavie S., Danek M., Sixsmith D., Heinrich G.F., and Mills S.S. Doing it right the first time: Quality improvement and the contaminant blood culture. J Clin Microbiol 35 (1997) 563-565
7. Washington II J.A., and Cumitech I.A. Blood cultures II. In: Reller L.B., Murray P.R., and MacLowry J.O. (Eds) (1982), American Society for Microbiology
8. Strand C.L., Wajsbort R.R., and Sturmann K. Effect of iodophor vs. iodine tincture skin preparation on blood culture contamination rate. JAMA 269 (1993) 1004-1006
9. Weinstein M.P., Towns M.L., Quartey S.M., Mirrett S., Reimer L.G., Parmagiani G., et al. The clinical significance of positive blood cultures in the 1990s: a prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteraemia and fungemia in adults. Clin Infect Dis 24 (1997) 584-602
10. Trautner B.W., Clarridge J.E., and Darouiche R.O. Skin antisepsis kits containing alcohol and chlorhexidine gluconate or tincture of iodine are associated with low rates of blood culture contamination. Infect Control Hosp Epidemiol 23 (2002) 397-401
11. Selwyn S., and Ellis H. Skin bacteria and skin disinfection reconsidered. BMJ 1 (1972) 136-139
12. Calfee D.P., and Farr B.M. Comparison of four antiseptic preparations for skin in the prevention of contamination of percutaneously drawn blood cultures: a randomised trial. J Clin Microbiol 40 (2002) 1660-1665
13. Mimoz O., Karim A., Mercat M., Cosserson M., Falissard B., Parker F., et al. Chlorhexidine compared with povidone-iodine as skin preparation before blood culture. Ann Intern Med 131 (1999) 834-837
14. Barenfanger J., Drake C., Lawhorn J., and Verhulst S.J. Comparison of chlorhexidine and tincture of iodine for skin antisepsis in preparation for blood sample collection. J Clin Microbiol 42 (2004) 2216-2217
15. Suwanpimolkul G., Pongkumpai M., and Suankratay C. A randomized trial of 2% chlorhexidine tincture compared with 10% aqueous povidone-iodine for venipuncture site disinfection: effects on blood culture contamination rates. J Infect 56 (2008) 354-359
16. Adams D., Quayum M., Worthington T., Lamert P., and Elliott T. Evaluation of 2% chlorhexidine gluconate in 70% isopropyl alcohol skin disinfectant. J Hosp Infect 61 (2005) 287-290
17. Saving lives: reducing infection, delivering clean and safe care (2007), Department of Health
18. Malani A., Trimble K., Parekh V., Chenoweth C., Kaufman S., and Saint S. Review of clinical trials of skin antiseptic agents used to reduce blood culture contamination. Infect Control Hosp Epidemiol 28 (2007) 892-895
19. McDonald C.P., Biggs C., Lees B., Beckman N., Kellington J., and Evans G. Evaluation and routine performance of a 'best practice' donor arm disinfection procedure: ChloraPrep. Vox Sanguinis 91 S3 (2006) P150