Dynamic models for the study of frailty

Mechanisms of Ageing and Development

Volumn 129, Issue 11, 2008, Pages 675-676

  Lipsitz, Lewis A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Aging; Complexity; Dynamics; Fractals; Frailty; Homeostatic; Mathematical Models; Physiology; Stimulus response

Indexed keywords

AGING; ARTICLE; FRAILTY; HOMEOSTASIS; MATHEMATICAL MODEL; PHYSIOLOGY; PRIORITY JOURNAL; STIMULUS RESPONSE;

AGED; AGED, 80 AND OVER; AGING; BIOLOGICAL MARKERS; DISEASE SUSCEPTIBILITY; FEEDBACK, BIOCHEMICAL; FRACTALS; FRAIL ELDERLY; HOMEOSTASIS; HUMANS; MODELS, BIOLOGICAL; PHENOTYPE; REPRODUCIBILITY OF RESULTS; STRESS, PHYSIOLOGICAL; SYSTEMS BIOLOGY; TIME FACTORS;

EID: 56949097875     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2008.09.012     Document Type: Article

References (7)

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3. Lipsitz L.A. The dynamics of stability: the physiologic basis of functional health and frailty. J. Gerontol. Biol. Sci. 57A 3 (2002) B115-B125
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6. Varadhan R., Seplaki C.S., Xue Q.L., Bandeen-Roche K., and Fried L.P. Stimulus-response paradigm for characterizing the loss of resilience in homeostatic regulation associated with frailty. Mech. Ageing Dev. 129 (2008) 666-670
7. Walston J., McBurnie M.A., Newman A., Tracy R.P., Kop W.J., Hirsch C.H., Gottdiener J., and Fried L.P. Cardiovascular Health Study Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study. Arch. Intern. Med. 162 (2002) 2333-2341